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126 results
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Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer.
Hofmann F, García-Echeverría C. Hofmann F, et al. Drug Discov Today. 2005 Aug 1;10(15):1041-7. doi: 10.1016/S1359-6446(05)03512-9. Drug Discov Today. 2005. PMID: 16055020 Review.
Lead optimization attrition analysis (LOAA): a novel and general methodology for medicinal chemistry.
Munson M, Lieberman H, Tserlin E, Rocnik J, Ge J, Fitzgerald M, Patel V, Garcia-Echeverria C. Munson M, et al. Among authors: garcia echeverria c. Drug Discov Today. 2015 Aug;20(8):978-87. doi: 10.1016/j.drudis.2015.03.010. Epub 2015 Mar 24. Drug Discov Today. 2015. PMID: 25814036 Review.
Allosteric and ATP-competitive kinase inhibitors of mTOR for cancer treatment.
García-Echeverría C. García-Echeverría C. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4308-12. doi: 10.1016/j.bmcl.2010.05.099. Epub 2010 Jun 1. Bioorg Med Chem Lett. 2010. PMID: 20561789 Review.
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.
Guagnano V, Kauffmann A, Wöhrle S, Stamm C, Ito M, Barys L, Pornon A, Yao Y, Li F, Zhang Y, Chen Z, Wilson CJ, Bordas V, Le Douget M, Gaither LA, Borawski J, Monahan JE, Venkatesan K, Brümmendorf T, Thomas DM, Garcia-Echeverria C, Hofmann F, Sellers WR, Graus-Porta D. Guagnano V, et al. Cancer Discov. 2012 Dec;2(12):1118-33. doi: 10.1158/2159-8290.CD-12-0210. Epub 2012 Sep 20. Cancer Discov. 2012. PMID: 23002168
Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma.
Manara MC, Landuzzi L, Nanni P, Nicoletti G, Zambelli D, Lollini PL, Nanni C, Hofmann F, García-Echeverría C, Picci P, Scotlandi K. Manara MC, et al. Clin Cancer Res. 2007 Feb 15;13(4):1322-30. doi: 10.1158/1078-0432.CCR-06-1518. Clin Cancer Res. 2007. PMID: 17317844
Repression of malignant tumor progression upon pharmacologic IGF1R blockade in a mouse model of insulinoma.
Zumsteg A, Caviezel C, Pisarsky L, Strittmatter K, García-Echeverría C, Hofmann F, Christofori G. Zumsteg A, et al. Mol Cancer Res. 2012 Jun;10(6):800-9. doi: 10.1158/1541-7786.MCR-11-0522. Epub 2012 May 4. Mol Cancer Res. 2012. PMID: 22562956
PI3K/PTEN/Akt pathway status affects the sensitivity of high-grade glioma cell cultures to the insulin-like growth factor-1 receptor inhibitor NVP-AEW541.
Hägerstrand D, Lindh MB, Peña C, Garcia-Echeverria C, Nistér M, Hofmann F, Ostman A. Hägerstrand D, et al. Neuro Oncol. 2010 Sep;12(9):967-75. doi: 10.1093/neuonc/noq029. Epub 2010 Apr 8. Neuro Oncol. 2010. PMID: 20378689 Free PMC article.
The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.
Maiso P, Ocio EM, Garayoa M, Montero JC, Hofmann F, García-Echeverría C, Zimmermann J, Pandiella A, San Miguel JF. Maiso P, et al. Br J Haematol. 2008 May;141(4):470-82. doi: 10.1111/j.1365-2141.2008.07049.x. Epub 2008 Mar 12. Br J Haematol. 2008. PMID: 18341634
Antitumor activity of the insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 in musculoskeletal tumors.
Scotlandi K, Manara MC, Nicoletti G, Lollini PL, Lukas S, Benini S, Croci S, Perdichizzi S, Zambelli D, Serra M, García-Echeverría C, Hofmann F, Picci P. Scotlandi K, et al. Cancer Res. 2005 May 1;65(9):3868-76. doi: 10.1158/0008-5472.CAN-04-3192. Cancer Res. 2005. PMID: 15867386
The insulin-like growth factor-I receptor kinase inhibitor, NVP-ADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy.
Warshamana-Greene GS, Litz J, Buchdunger E, García-Echeverría C, Hofmann F, Krystal GW. Warshamana-Greene GS, et al. Clin Cancer Res. 2005 Feb 15;11(4):1563-71. doi: 10.1158/1078-0432.CCR-04-1544. Clin Cancer Res. 2005. PMID: 15746061
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