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A novel polymorphism in a forkhead box A1 (FOXA1) binding site of the human UDP glucuronosyltransferase 2B17 gene modulates promoter activity and is associated with altered levels of circulating androstane-3α,17β-diol glucuronide.
Hu DG, Gardner-Stephen D, Severi G, Gregory PA, Treloar J, Giles GG, English DR, Hopper JL, Tilley WD, Mackenzie PI. Hu DG, et al. Mol Pharmacol. 2010 Oct;78(4):714-22. doi: 10.1124/mol.110.065953. Epub 2010 Jul 13. Mol Pharmacol. 2010. PMID: 20628005
Regulation of UDP glucuronosyltransferase genes.
Mackenzie PI, Gregory PA, Gardner-Stephen DA, Lewinsky RH, Jorgensen BR, Nishiyama T, Xie W, Radominska-Pandya A. Mackenzie PI, et al. Curr Drug Metab. 2003 Jun;4(3):249-57. doi: 10.2174/1389200033489442. Curr Drug Metab. 2003. PMID: 12769669 Review.
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