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Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74.
Miller PS, Barwell J, Poyner DR, Wigglesworth MJ, Garland SL, Donnelly D. Miller PS, et al. Among authors: garland sl. Biochem Biophys Res Commun. 2010 Jan 1;391(1):437-42. doi: 10.1016/j.bbrc.2009.11.076. Epub 2009 Nov 13. Biochem Biophys Res Commun. 2010. PMID: 19914210 Free PMC article.
The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2.
D'Alessandro PL, Corti C, Roth A, Ugolini A, Sava A, Montanari D, Bianchi F, Garland SL, Powney B, Koppe EL, Rocheville M, Osborne G, Perez P, de la Fuente J, De Los Frailes M, Smith PW, Branch C, Nash D, Watson SP. D'Alessandro PL, et al. Among authors: garland sl. Bioorg Med Chem Lett. 2010 Jan 15;20(2):759-62. doi: 10.1016/j.bmcl.2009.11.032. Epub 2009 Nov 26. Bioorg Med Chem Lett. 2010. PMID: 20005096
Potent oxadiazole CGRP receptor antagonists for the potential treatment of migraine.
Nichols PL, Brand J, Briggs M, D'Angeli M, Farge J, Garland SL, Goldsmith P, Hutchings R, Kilford I, Li HY, MacPherson D, Nimmo F, Sanderson FD, Sehmi S, Shuker N, Skidmore J, Stott M, Sweeting J, Tajuddin H, Takle AK, Trani G, Wall ID, Ward R, Wilson DM, Witty D. Nichols PL, et al. Among authors: garland sl. Bioorg Med Chem Lett. 2010 Feb 15;20(4):1368-72. doi: 10.1016/j.bmcl.2010.01.012. Epub 2010 Jan 11. Bioorg Med Chem Lett. 2010. PMID: 20097071
21 results