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Genetic analysis of insulin signaling in Drosophila.
Garofalo RS. Garofalo RS. Trends Endocrinol Metab. 2002 May-Jun;13(4):156-62. doi: 10.1016/s1043-2760(01)00548-3. Trends Endocrinol Metab. 2002. PMID: 11943559 Review.
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta.
Garofalo RS, Orena SJ, Rafidi K, Torchia AJ, Stock JL, Hildebrandt AL, Coskran T, Black SC, Brees DJ, Wicks JR, McNeish JD, Coleman KG. Garofalo RS, et al. J Clin Invest. 2003 Jul;112(2):197-208. doi: 10.1172/JCI16885. Epub 2003 Jul 3. J Clin Invest. 2003. PMID: 12843127 Free PMC article.
Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation.
Greene MW, Garofalo RS. Greene MW, et al. Among authors: garofalo rs. Biochemistry. 2002 Jun 4;41(22):7082-91. doi: 10.1021/bi015992f. Biochemistry. 2002. PMID: 12033942
Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes.
Oreña SJ, Torchia AJ, Garofalo RS. Oreña SJ, et al. Among authors: garofalo rs. J Biol Chem. 2000 May 26;275(21):15765-72. doi: 10.1074/jbc.M910002199. J Biol Chem. 2000. PMID: 10748179
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function.
Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS. Tatar M, et al. Among authors: garofalo rs. Science. 2001 Apr 6;292(5514):107-10. doi: 10.1126/science.1057987. Science. 2001. PMID: 11292875 Free article.
A developmentally regulated form of insulin-like growth factor receptor beta-subunit in C2 myoblasts exhibiting altered requirements for differentiation.
Barenton B, Domeyne A, Garandel V, Garofalo RS. Barenton B, et al. Among authors: garofalo rs. Endocrinology. 1993 Aug;133(2):651-60. doi: 10.1210/endo.133.2.8344204. Endocrinology. 1993. PMID: 8344204
The carboxyl terminal extension of the Drosophila insulin receptor homologue binds IRS-1 and influences cell survival.
Marin-Hincapie M, Garofalo RS. Marin-Hincapie M, et al. Among authors: garofalo rs. J Biol Chem. 1999 Aug 27;274(35):24987-94. doi: 10.1074/jbc.274.35.24987. J Biol Chem. 1999. PMID: 10455177
The Drosophila insulin receptor is required for normal growth.
Chen C, Jack J, Garofalo RS. Chen C, et al. Among authors: garofalo rs. Endocrinology. 1996 Mar;137(3):846-56. doi: 10.1210/endo.137.3.8603594. Endocrinology. 1996. PMID: 8603594
The Drosophila insulin receptor contains a novel carboxyl-terminal extension likely to play an important role in signal transduction.
Ruan Y, Chen C, Cao Y, Garofalo RS. Ruan Y, et al. Among authors: garofalo rs. J Biol Chem. 1995 Mar 3;270(9):4236-43. doi: 10.1074/jbc.270.9.4236. J Biol Chem. 1995. PMID: 7876183
Drosophila insulin receptor: lectin-binding properties and a role for oxidation-reduction of receptor thiols in activation.
Marin-Hincapie M, Garofalo RS. Marin-Hincapie M, et al. Among authors: garofalo rs. Endocrinology. 1995 Jun;136(6):2357-66. doi: 10.1210/endo.136.6.7750456. Endocrinology. 1995. PMID: 7750456
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