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Organization and regulation of mitogen-activated protein kinase signaling pathways.
Garrington TP, Johnson GL. Garrington TP, et al. Curr Opin Cell Biol. 1999 Apr;11(2):211-8. doi: 10.1016/s0955-0674(99)80028-3. Curr Opin Cell Biol. 1999. PMID: 10209154 Review.
MEF2C regulates c-Jun but not TNF-alpha gene expression in stimulated mast cells.
Wei X, Sun W, Fan R, Hahn J, Joetham A, Li G, Webb S, Garrington T, Dakhama A, Lucas J, Johnson GL, Gelfand EW. Wei X, et al. Among authors: garrington t. Eur J Immunol. 2003 Oct;33(10):2903-9. doi: 10.1002/eji.200324127. Eur J Immunol. 2003. PMID: 14515274
MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts.
Kesavan K, Lobel-Rice K, Sun W, Lapadat R, Webb S, Johnson GL, Garrington TP. Kesavan K, et al. Among authors: garrington tp. J Cell Physiol. 2004 Apr;199(1):140-8. doi: 10.1002/jcp.10457. J Cell Physiol. 2004. PMID: 14978743
MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src.
Sun W, Wei X, Kesavan K, Garrington TP, Fan R, Mei J, Anderson SM, Gelfand EW, Johnson GL. Sun W, et al. Among authors: garrington tp. Mol Cell Biol. 2003 Apr;23(7):2298-308. doi: 10.1128/mcb.23.7.2298-2308.2003. Mol Cell Biol. 2003. PMID: 12640115 Free PMC article.
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.
Garrington TP, Ishizuka T, Papst PJ, Chayama K, Webb S, Yujiri T, Sun W, Sather S, Russell DM, Gibson SB, Keller G, Gelfand EW, Johnson GL. Garrington TP, et al. EMBO J. 2000 Oct 16;19(20):5387-95. doi: 10.1093/emboj/19.20.5387. EMBO J. 2000. PMID: 11032806 Free PMC article.
Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.
Chayama K, Papst PJ, Garrington TP, Pratt JC, Ishizuka T, Webb S, Ganiatsas S, Zon LI, Sun W, Johnson GL, Gelfand EW. Chayama K, et al. Among authors: garrington tp. Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4599-604. doi: 10.1073/pnas.081021898. Epub 2001 Mar 27. Proc Natl Acad Sci U S A. 2001. PMID: 11274363 Free PMC article.
MEKK2 associates with the adapter protein Lad/RIBP and regulates the MEK5-BMK1/ERK5 pathway.
Sun W, Kesavan K, Schaefer BC, Garrington TP, Ware M, Johnson NL, Gelfand EW, Johnson GL. Sun W, et al. Among authors: garrington tp. J Biol Chem. 2001 Feb 16;276(7):5093-100. doi: 10.1074/jbc.M003719200. Epub 2000 Nov 9. J Biol Chem. 2001. PMID: 11073940
MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton.
Yujiri T, Fanger GR, Garrington TP, Schlesinger TK, Gibson S, Johnson GL. Yujiri T, et al. Among authors: garrington tp. J Biol Chem. 1999 Apr 30;274(18):12605-10. doi: 10.1074/jbc.274.18.12605. J Biol Chem. 1999. PMID: 10212239
Reovirus-induced apoptosis is mediated by TRAIL.
Clarke P, Meintzer SM, Gibson S, Widmann C, Garrington TP, Johnson GL, Tyler KL. Clarke P, et al. Among authors: garrington tp. J Virol. 2000 Sep;74(17):8135-9. doi: 10.1128/jvi.74.17.8135-8139.2000. J Virol. 2000. PMID: 10933724 Free PMC article.
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage.
Bild AH, Mendoza FJ, Gibson EM, Huang M, Villanueva J, Garrington TP, Jove R, Johnson GL, Gibson SB. Bild AH, et al. Among authors: garrington tp. Oncogene. 2002 Sep 26;21(43):6649-56. doi: 10.1038/sj.onc.1205819. Oncogene. 2002. PMID: 12242663
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