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The pre-metastatic niche: is metastasis random?
Cox TR, Gartland A, Erler JT. Cox TR, et al. Among authors: gartland a. Bonekey Rep. 2012 May 2;1:80. doi: 10.1038/bonekey.2012.80. eCollection 2012. Bonekey Rep. 2012. PMID: 27127624 Free PMC article. Review.
The metastasis of solid tumours is a vastly complex, dynamic and systemic process involving both primary tumour cells as well as a wide array of stromal and vascular cells. ...Exactly how a tumour cell can alter the distant metastatic microenvironment is of g …
The metastasis of solid tumours is a vastly complex, dynamic and systemic process involving both primary tumour cells as well as a
The role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis.
Gartland A, Erler JT, Cox TR. Gartland A, et al. J Bone Oncol. 2016 Jul 1;5(3):100-103. doi: 10.1016/j.jbo.2016.04.001. eCollection 2016 Sep. J Bone Oncol. 2016. PMID: 27761366 Free PMC article.
Dataset for the proteomic inventory and quantitative analysis of the breast cancer hypoxic secretome associated with osteotropism.
Cox TR, Schoof EM, Gartland A, Erler JT, Linding R. Cox TR, et al. Among authors: gartland a. Data Brief. 2015 Oct 23;5:621-5. doi: 10.1016/j.dib.2015.09.039. eCollection 2015 Dec. Data Brief. 2015. PMID: 26649326 Free PMC article.
Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis.
Cox TR, Gartland A, Erler JT. Cox TR, et al. Among authors: gartland a. Cancer Res. 2016 Jan 15;76(2):188-92. doi: 10.1158/0008-5472.CAN-15-2306. Epub 2016 Jan 5. Cancer Res. 2016. PMID: 26732355 Review.
We showed that in models of breast cancer metastasis, targeting LOX, or its downstream effects, significantly inhibited premetastatic niche formation and the resulting metastatic burden, offering preclinical validation of this enzyme as a therapeutic target for metastatic …
We showed that in models of breast cancer metastasis, targeting LOX, or its downstream effects, significantly inhibited premetastatic niche …
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase.
Cox TR, Rumney RMH, Schoof EM, Perryman L, Høye AM, Agrawal A, Bird D, Latif NA, Forrest H, Evans HR, Huggins ID, Lang G, Linding R, Gartland A, Erler JT. Cox TR, et al. Among authors: gartland a. Nature. 2015 Jun 4;522(7554):106-110. doi: 10.1038/nature14492. Epub 2015 May 27. Nature. 2015. PMID: 26017313 Free PMC article.
We show that these lesions subsequently provide a platform for circulating tumour cells to colonize and form bone metastases. Our study identifies a novel mechanism of regulation of bone homeostasis and metastasis, opening up opportunities for novel therapeutic inte …
We show that these lesions subsequently provide a platform for circulating tumour cells to colonize and form bone metastases. Our stu …
P2X7 receptor regulates osteoclast function and bone loss in a mouse model of osteoporosis.
Wang N, Agrawal A, Jørgensen NR, Gartland A. Wang N, et al. Among authors: gartland a. Sci Rep. 2018 Feb 22;8(1):3507. doi: 10.1038/s41598-018-21574-9. Sci Rep. 2018. PMID: 29472582 Free PMC article.
Purinergic signalling in bone.
Rumney RM, Wang N, Agrawal A, Gartland A. Rumney RM, et al. Among authors: gartland a. Front Endocrinol (Lausanne). 2012 Sep 19;3:116. doi: 10.3389/fendo.2012.00116. eCollection 2012. Front Endocrinol (Lausanne). 2012. PMID: 23049524 Free PMC article.
This review will highlight the most recent developments in the field of purinergic signaling in bone, with a special emphasis on recent work resulting from the European Framework 7 funded collaboration ATPBone, as well as Arthritis Research UK and Bone Research Society sup …
This review will highlight the most recent developments in the field of purinergic signaling in bone, with a special emphasis on rece …
Isolation and culture of human osteoblasts.
Gartland A, Rumney RM, Dillon JP, Gallagher JA. Gartland A, et al. Methods Mol Biol. 2012;806:337-55. doi: 10.1007/978-1-61779-367-7_22. Methods Mol Biol. 2012. PMID: 22057462
In this chapter, we concentrate on bone formation, providing a detailed guide to isolating and culturing primary human osteoblasts in bone explant cultures, as well as the methodology used to characterise and monitor the function of osteoblasts. In combination, these metho …
In this chapter, we concentrate on bone formation, providing a detailed guide to isolating and culturing primary human osteoblasts in …
Polymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal women.
Gartland A, Skarratt KK, Hocking LJ, Parsons C, Stokes L, Jørgensen NR, Fraser WD, Reid DM, Gallagher JA, Wiley JS. Gartland A, et al. Eur J Hum Genet. 2012 May;20(5):559-64. doi: 10.1038/ejhg.2011.245. Epub 2012 Jan 11. Eur J Hum Genet. 2012. PMID: 22234152 Free PMC article.
The P2X7 receptor gene (P2RX7) is highly polymorphic with five previously described loss-of-function (LOF) single-nucleotide polymorphisms (SNP; c.151+1G>T, c.946G>A, c.1096C>G, c.1513A>C and c.1729T>A) and one gain-of-function SNP (c.489C>T). The …
The P2X7 receptor gene (P2RX7) is highly polymorphic with five previously described loss-of-function (LOF) single-nucleotide polymorphisms ( …
Cobalt and chromium exposure affects osteoblast function and impairs the mineralization of prosthesis surfaces in vitro.
Shah KM, Wilkinson JM, Gartland A. Shah KM, et al. Among authors: gartland a. J Orthop Res. 2015 Nov;33(11):1663-70. doi: 10.1002/jor.22932. Epub 2015 May 18. J Orthop Res. 2015. PMID: 25929464
Cellular activity and ALP activity were reduced to a greater extent with combination treatments compared to individual ions. ...
Cellular activity and ALP activity were reduced to a greater extent with combination treatments compared to individual ions. ...
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