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Genetic background modifies phenotypic severity and longevity in a mouse model of Niemann-Pick disease type C1.
Rodriguez-Gil JL, Watkins-Chow DE, Baxter LL, Elliot G, Harper UL, Wincovitch SM, Wedel JC, Incao AA, Huebecker M, Boehm FJ, Garver WS, Porter FD, Broman KW, Platt FM, Pavan WJ. Rodriguez-Gil JL, et al. Among authors: Garver WS. Dis Model Mech. 2020 Jan 29;13(3):dmm042614. doi: 10.1242/dmm.042614. Online ahead of print. Dis Model Mech. 2020. PMID: 31996359 Free PMC article.
The Niemann-Pick C1 gene is downregulated in livers of C57BL/6J mice by dietary fatty acids, but not dietary cholesterol, through feedback inhibition of the SREBP pathway.
Jelinek D, Castillo JJ, Richardson LM, Luo L, Heidenreich RA, Garver WS. Jelinek D, et al. Among authors: Garver WS. J Nutr. 2012 Nov;142(11):1935-42. doi: 10.3945/jn.112.162818. Epub 2012 Sep 18. J Nutr. 2012. PMID: 22990467 Free PMC article.
Differential Association of Niemann-Pick C1 Gene Polymorphisms with Maternal Prepregnancy Overweight and Gestational Diabetes.
Garver WS, de la Torre L, Brennan MC, Luo L, Jelinek D, Castillo JJ, Meyre D, Orlando RA, Heidenreich RA, Rayburn WF. Garver WS, et al. J Diabetes Obes. 2015;2(1):10.15436/2376-0494.15.007. doi: 10.15436/2376-0494.15.007. J Diabetes Obes. 2015. PMID: 26120596 Free PMC article.
The Niemann-Pick C1 gene interacts with a high-fat diet to promote weight gain through differential regulation of central energy metabolism pathways.
Castillo JJ, Jelinek D, Wei H, Gannon NP, Vaughan RA, Horwood LJ, Meaney FJ, Garcia-Smith R, Trujillo KA, Heidenreich RA, Meyre D, Orlando RA, LeBoeuf RC, Garver WS. Castillo JJ, et al. Among authors: Garver WS. Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E183-E194. doi: 10.1152/ajpendo.00369.2016. Epub 2017 May 9. Am J Physiol Endocrinol Metab. 2017. PMID: 28487438 Free PMC article.
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