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Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective.
Kaplan A, Gaschler MM, Dunn DE, Colligan R, Brown LM, Palmer AG 3rd, Lo DC, Stockwell BR. Kaplan A, et al. Among authors: gaschler mm. Proc Natl Acad Sci U S A. 2015 Apr 28;112(17):E2245-52. doi: 10.1073/pnas.1500439112. Epub 2015 Apr 6. Proc Natl Acad Sci U S A. 2015. PMID: 25848045 Free PMC article.
Lipid peroxidation in cell death.
Gaschler MM, Stockwell BR. Gaschler MM, et al. Biochem Biophys Res Commun. 2017 Jan 15;482(3):419-425. doi: 10.1016/j.bbrc.2016.10.086. Epub 2017 Feb 3. Biochem Biophys Res Commun. 2017. PMID: 28212725 Free PMC article. Review.
FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation.
Gaschler MM, Andia AA, Liu H, Csuka JM, Hurlocker B, Vaiana CA, Heindel DW, Zuckerman DS, Bos PH, Reznik E, Ye LF, Tyurina YY, Lin AJ, Shchepinov MS, Chan AY, Peguero-Pereira E, Fomich MA, Daniels JD, Bekish AV, Shmanai VV, Kagan VE, Mahal LK, Woerpel KA, Stockwell BR. Gaschler MM, et al. Nat Chem Biol. 2018 May;14(5):507-515. doi: 10.1038/s41589-018-0031-6. Epub 2018 Apr 2. Nat Chem Biol. 2018. PMID: 29610484 Free PMC article.