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The nucleoporin RanBP2 has SUMO1 E3 ligase activity.
Pichler A, Gast A, Seeler JS, Dejean A, Melchior F. Pichler A, et al. Cell. 2002 Jan 11;108(1):109-20. doi: 10.1016/s0092-8674(01)00633-x. Cell. 2002. PMID: 11792325
A family of E3-like factors, PIAS proteins, was discovered recently. Here we show that the nucleoporin RanBP2/Nup358 also has SUMO1 E3-like activity. ...The E3-like activity is contained within a 33 kDa domain of RanBP2 that lacks RING finger motifs and does not res
A family of E3-like factors, PIAS proteins, was discovered recently. Here we show that the nucleoporin RanBP2/Nup358 also has SUMO1 E
The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.
Kirsh O, Seeler JS, Pichler A, Gast A, Müller S, Miska E, Mathieu M, Harel-Bellan A, Kouzarides T, Melchior F, Dejean A. Kirsh O, et al. EMBO J. 2002 Jun 3;21(11):2682-91. doi: 10.1093/emboj/21.11.2682. EMBO J. 2002. PMID: 12032081 Free PMC article.
A sumoylation-deficient point mutant (HDAC4-K559R) shows a slightly impaired ability to repress transcription as well as reduced histone deacetylase activity. ...Moreover, the modification depends on the presence of an intact nuclear localization signal and is catal
A sumoylation-deficient point mutant (HDAC4-K559R) shows a slightly impaired ability to repress transcription as well as reduc
Opposed regulation of corepressor CtBP by SUMOylation and PDZ binding.
Lin X, Sun B, Liang M, Liang YY, Gast A, Hildebrand J, Brunicardi FC, Melchior F, Feng XH. Lin X, et al. Mol Cell. 2003 May;11(5):1389-96. doi: 10.1016/s1097-2765(03)00175-8. Mol Cell. 2003. PMID: 12769861
SUMOylation occurred at a single Lys residue, Lys428, of CtBP1. CtBP2, a close homolog of CtBP1, lacked the SUMOylation site and was not modified by SUMO-1. ...This study identifies SUMOylation as a regulatory mechanism underlying CtBP1-dependent transcriptio …
SUMOylation occurred at a single Lys residue, Lys428, of CtBP1. CtBP2, a close homolog of CtBP1, lacked the SUMOylation site a …
A distinct modulating domain in glucocorticoid receptor monomers in the repression of activity of the transcription factor AP-1.
Heck S, Kullmann M, Gast A, Ponta H, Rahmsdorf HJ, Herrlich P, Cato AC. Heck S, et al. EMBO J. 1994 Sep 1;13(17):4087-95. EMBO J. 1994. PMID: 8076604 Free PMC article.
The activity of AP-1 is inhibited by the receptor, a mechanism exploited for the therapy of various forms of pathological hyperproliferation in humans. ...While DNA binding and activation of glucocorticoid-regulated promoters require GR dimerization, we present data that s …
The activity of AP-1 is inhibited by the receptor, a mechanism exploited for the therapy of various forms of pathological hyperprolif …
N-terminal sequences of the human androgen receptor in DNA binding and transrepressing functions.
Gast A, Schneikert J, Cato AC. Gast A, et al. J Steroid Biochem Mol Biol. 1998 Apr;65(1-6):117-23. doi: 10.1016/s0960-0760(97)00176-3. J Steroid Biochem Mol Biol. 1998. PMID: 9699864
Androgen receptor is a ligand binding transcription factor that controls several physiological processes ranging from the development of the male sexual organs to the acquisition of secondary sex characteristics. It is composed of a carboxy-terminal ligand binding d …
Androgen receptor is a ligand binding transcription factor that controls several physiological processes ranging from the development …
A single amino acid exchange abolishes dimerization of the androgen receptor and causes Reifenstein syndrome.
Gast A, Neuschmid-Kaspar F, Klocker H, Cato AC. Gast A, et al. Mol Cell Endocrinol. 1995 Apr 28;111(1):93-8. doi: 10.1016/0303-7207(95)03554-k. Mol Cell Endocrinol. 1995. PMID: 7649358
A single exchange of an alanine to a threonine at amino acid position 596 in the androgen receptor has been identified as an inheritable trait in patients with Reifenstein syndrome. This exchange is a result of a germ line mutation in the genomic DNA s
A single exchange of an alanine to a threonine at amino acid position 596 in the androgen receptor has been identified as an i
Activation of two mutant androgen receptors from human prostatic carcinoma by adrenal androgens and metabolic derivatives of testosterone.
Culig Z, Stober J, Gast A, Peterziel H, Hobisch A, Radmayr C, Hittmair A, Bartsch G, Cato AC, Klocker H. Culig Z, et al. Cancer Detect Prev. 1996;20(1):68-75. Cancer Detect Prev. 1996. PMID: 8907206
The androgen receptor (AR) plays a central regulatory role in prostatic carcinoma and is a target of androgen ablation therapy. ...In a specimen derived from metastatic prostate cancer we have reported a point mutation in the AR gene that leads to a
The androgen receptor (AR) plays a central regulatory role in prostatic carcinoma and is a target of androgen ablation therapy …
CAG-repeat expansion in androgen receptor in Kennedy's disease is not a loss of function mutation.
Neuschmid-Kaspar F, Gast A, Peterziel H, Schneikert J, Muigg A, Ransmayr G, Klocker H, Bartsch G, Cato AC. Neuschmid-Kaspar F, et al. Mol Cell Endocrinol. 1996 Mar 25;117(2):149-56. doi: 10.1016/0303-7207(95)03741-1. Mol Cell Endocrinol. 1996. PMID: 8737374
We have identified a trinucleotide repeat of 45 in the N-terminus of the AR in two brothers with SBMA and several members in their family (range in the general population is 11-35). ...These results together argue against SBMA being a loss of function mutation of th …
We have identified a trinucleotide repeat of 45 in the N-terminus of the AR in two brothers with SBMA and several members in their fa …
Differential gene expression in melanocytic nevi with the V600E BRAF mutation.
Bloethner S, Snellman E, Bermejo JL, Hiripi E, Gast A, Thirumaran RK, Wellenreuther R, Hemminki K, Kumar R. Bloethner S, et al. Genes Chromosomes Cancer. 2007 Nov;46(11):1019-27. doi: 10.1002/gcc.20488. Genes Chromosomes Cancer. 2007. PMID: 17696195
ARLTS1 polymorphisms and basal cell carcinoma of the skin.
Li X, Gast A, Rudnai P, Gurzau E, Koppova K, Hemminki K, Kumar R. Li X, et al. Hered Cancer Clin Pract. 2007 Mar 15;5(1):25-9. doi: 10.1186/1897-4287-5-1-25. Hered Cancer Clin Pract. 2007. PMID: 19723348 Free PMC article.
Polymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer types. ...In a case-control study, 529 cases diagnosed with BCC and 533 controls from Hungary, Romania and Slovakia were genotyped for th …
Polymorphisms in the ARLTS1 gene, a member of the Ras super-family, have been associated with susceptibility in different cancer type …
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