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Antitumor activity of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib (ZD1839, Iressa) in non-small cell lung cancer cell lines correlates with gene copy number and EGFR mutations but not EGFR protein levels.
Helfrich BA, Raben D, Varella-Garcia M, Gustafson D, Chan DC, Bemis L, Coldren C, Barón A, Zeng C, Franklin WA, Hirsch FR, Gazdar A, Minna J, Bunn PA Jr. Helfrich BA, et al. Clin Cancer Res. 2006 Dec 1;12(23):7117-25. doi: 10.1158/1078-0432.CCR-06-0760. Clin Cancer Res. 2006. PMID: 17145836
Focus on lung cancer.
Minna JD, Roth JA, Gazdar AF. Minna JD, et al. Among authors: gazdar af. Cancer Cell. 2002 Feb;1(1):49-52. doi: 10.1016/s1535-6108(02)00027-2. Cancer Cell. 2002. PMID: 12086887 Free article. Review. No abstract available.
Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer.
Toyooka S, Maruyama R, Toyooka KO, McLerran D, Feng Z, Fukuyama Y, Virmani AK, Zochbauer-Muller S, Tsukuda K, Sugio K, Shimizu N, Shimizu K, Lee H, Chen CY, Fong KM, Gilcrease M, Roth JA, Minna JD, Gazdar AF. Toyooka S, et al. Among authors: gazdar af. Int J Cancer. 2003 Jan 10;103(2):153-60. doi: 10.1002/ijc.10787. Int J Cancer. 2003. PMID: 12455028 Free article.
PIK3CA mutations and copy number gains in human lung cancers.
Yamamoto H, Shigematsu H, Nomura M, Lockwood WW, Sato M, Okumura N, Soh J, Suzuki M, Wistuba II, Fong KM, Lee H, Toyooka S, Date H, Lam WL, Minna JD, Gazdar AF. Yamamoto H, et al. Among authors: gazdar af. Cancer Res. 2008 Sep 1;68(17):6913-21. doi: 10.1158/0008-5472.CAN-07-5084. Cancer Res. 2008. PMID: 18757405 Free PMC article.
779 results