A lipase-responsive vehicle using amphipathic polymer synthesized with the lipase as catalyst

Jun Ge; Diannan Lu; Cheng Yang; Zheng Liu

doi:10.1002/marc.201000746

A lipase-responsive vehicle using amphipathic polymer synthesized with the lipase as catalyst

Macromol Rapid Commun. 2011 Mar 16;32(6):546-50. doi: 10.1002/marc.201000746. Epub 2011 Jan 21.

Authors

Jun Ge¹, Diannan Lu, Cheng Yang, Zheng Liu

Affiliation

¹ Department of Chemical Engineering, The State Key Lab of Chemical Engineering, Tsinghua University, Beijing 100084, China.

PMID: 21433214
DOI: 10.1002/marc.201000746

Abstract

We describe an enzyme-responsive polymeric vehicle, which is of great interest in controlled drug delivery, biosensing, and other related areas. The polymer synthesized using lipase as catalyst in DMSO has a favorable molecular structure that is quickly hydrolyzed by lipase in aqueous phase, and allows a fast release of encapsulated molecules.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Candida / drug effects
Catalysis
Drug Delivery Systems*
Humans
Lipase / administration & dosage
Lipase / chemistry*
Molecular Structure
Polyethylene Glycols / administration & dosage
Polyethylene Glycols / chemistry
Polymers / chemical synthesis
Polymers / chemistry*
Water / chemistry

Substances

Polymers
Water
Polyethylene Glycols
Lipase