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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 1
1971 1
1972 1
1973 2
1974 1
1975 1
1976 7
1977 4
1978 8
1979 4
1980 2
1981 2
1982 5
1983 2
1984 4
1985 3
1986 5
1987 7
1988 3
1989 8
1990 5
1991 8
1992 8
1993 9
1994 6
1995 14
1996 7
1997 12
1998 7
1999 8
2000 8
2001 10
2002 14
2003 12
2004 9
2005 13
2006 9
2007 14
2008 17
2009 15
2010 10
2011 9
2012 10
2013 8
2014 10
2015 8
2016 6
2017 6
2018 6
2019 6
2020 0
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340 results
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Page 1
Repair-Resistant DNA Lesions
Geacintov NE and Broyde S. Chem Res Toxicol 2017 - Review. PMID 28750166 Free PMC article.
Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase
Rechkoblit O, et al. Nat Commun 2017. Among authors: Geacintov NE. PMID 29042535 Free PMC article.
Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2) amino group of guanine to generate four stereoisomeric BP-N (2)-dG adducts. ...Here we report high-resolution structures of yeast Rev1 with three BP-N (2)-dG adducts, namely the 10S (+)-trans-BP-N (2)-dG, 10R (+)-cis-BP-N (2)-dG, and 10S ( - )-cis-BP-N (2)-dG. ...
Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2) amino gr …
Variable impact of conformationally distinct DNA lesions on nucleosome structure and dynamics: Implications for nucleotide excision repair
Cai Y, et al. DNA Repair (Amst) 2019. Among authors: Geacintov NE. PMID 32018112
In the present study, we utilized molecular dynamics simulations to elucidate the nature of the distortions and dynamics imposed in the nucleosome by a set of three structually different lesions that vary in GG-NER efficiencies in free DNA, and in nucleosomes [Shafirovich, Geacintov, et. al, 2019]. Two of these are bulky lesions derived from metabolic activation of the environmental carcinogen benzo[a]pyrene, the 10R (+)-cis-anti-B[a]P-N(2)-dG and the stereoisomeric 10S (+)-trans-anti-B[a]P-N(2)-dG, which respectively adopt base-displaced/intercalated and minor groove-aligned conformations in DNA. ...
In the present study, we utilized molecular dynamics simulations to elucidate the nature of the distortions and dynamics imposed in the nucl …
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