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Quantitative Systems Pharmacology for Neuroscience Drug Discovery and Development: Current Status, Opportunities, and Challenges.
Geerts H, Wikswo J, van der Graaf PH, Bai JPF, Gaiteri C, Bennett D, Swalley SE, Schuck E, Kaddurah-Daouk R, Tsaioun K, Pelleymounter M. Geerts H, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Jan;9(1):5-20. doi: 10.1002/psp4.12478. Epub 2019 Nov 24. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 31674729 Free PMC article.
Salvaging CNS Clinical Trials Halted Due to COVID-19.
Geerts H, van der Graaf PH. Geerts H, et al. CPT Pharmacometrics Syst Pharmacol. 2020 Jul;9(7):367-370. doi: 10.1002/psp4.12535. Epub 2020 Jun 28. CPT Pharmacometrics Syst Pharmacol. 2020. PMID: 32468710 Free PMC article. No abstract available.
Challenges in Alzheimer's Disease Drug Discovery and Development: The Role of Modeling, Simulation, and Open Data.
Conrado DJ, Duvvuri S, Geerts H, Burton J, Biesdorf C, Ahamadi M, Macha S, Hather G, Francisco Morales J, Podichetty J, Nicholas T, Stephenson D, Trame M, Romero K, Corrigan B; Drug Development Tools in the Alzheimer Disease Continuum (DDT-AD) Working Group. Conrado DJ, et al. Among authors: geerts h. Clin Pharmacol Ther. 2020 Apr;107(4):796-805. doi: 10.1002/cpt.1782. Epub 2020 Mar 11. Clin Pharmacol Ther. 2020. PMID: 31955409 Review.
MiRNA-15b and miRNA-125b are associated with regional Aβ-PET and FDG-PET uptake in cognitively normal individuals with subjective memory complaints.
Vergallo A, Lista S, Zhao Y, Lemercier P, Teipel SJ, Potier MC, Habert MO, Dubois B, Lukiw WJ, Hampel H; INSIGHT-preAD study group; Alzheimer Precision Medicine Initiative (APMI). Vergallo A, et al. Transl Psychiatry. 2021 Jan 27;11(1):78. doi: 10.1038/s41398-020-01184-8. Transl Psychiatry. 2021. PMID: 33504764 Free PMC article.
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