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Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma.
Siska PJ, Beckermann KE, Mason FM, Andrejeva G, Greenplate AR, Sendor AB, Chiang YJ, Corona AL, Gemta LF, Vincent BG, Wang RC, Kim B, Hong J, Chen CL, Bullock TN, Irish JM, Rathmell WK, Rathmell JC. Siska PJ, et al. Among authors: gemta lf. JCI Insight. 2017 Jun 15;2(12):e93411. doi: 10.1172/jci.insight.93411. eCollection 2017 Jun 15. JCI Insight. 2017. PMID: 28614802 Free PMC article.
Modulation of PKM activity affects the differentiation of TH17 cells.
Seki SM, Posyniak K, McCloud R, Rosen DA, Fernández-Castañeda A, Beiter RM, Serbulea V, Nanziri SC, Hayes N, Spivey C, Gemta L, Bullock TNJ, Hsu KL, Gaultier A. Seki SM, et al. Among authors: gemta l. Sci Signal. 2020 Oct 27;13(655):eaay9217. doi: 10.1126/scisignal.aay9217. Sci Signal. 2020. PMID: 33109748 Free PMC article.
Tyrosine kinase inhibition in leukemia induces an altered metabolic state sensitive to mitochondrial perturbations.
Alvarez-Calderon F, Gregory MA, Pham-Danis C, DeRyckere D, Stevens BM, Zaberezhnyy V, Hill AA, Gemta L, Kumar A, Kumar V, Wempe MF, Pollyea DA, Jordan CT, Serkova NJ, Graham DK, DeGregori J. Alvarez-Calderon F, et al. Among authors: gemta l. Clin Cancer Res. 2015 Mar 15;21(6):1360-72. doi: 10.1158/1078-0432.CCR-14-2146. Epub 2014 Dec 29. Clin Cancer Res. 2015. PMID: 25547679 Free PMC article.