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Gingival transcriptome patterns during induction and resolution of experimental gingivitis in humans.
Offenbacher S, Barros SP, Paquette DW, Winston JL, Biesbrock AR, Thomason RG, Gibb RD, Fulmer AW, Tiesman JP, Juhlin KD, Wang SL, Reichling TD, Chen KS, Ho B. Offenbacher S, et al. J Periodontol. 2009 Dec;80(12):1963-82. doi: 10.1902/jop.2009.080645. J Periodontol. 2009. PMID: 19961380
BACKGROUND: To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the induction and resolution of experimental gingivitis in humans were not previously explored using bioinformatic tools. METHODS: …
BACKGROUND: To our knowledge, changes in the patterns of whole-transcriptome gene expression that occur during the indu …
Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells.
Libro R, Diomede F, Scionti D, Piattelli A, Grassi G, Pollastro F, Bramanti P, Mazzon E, Trubiani O. Libro R, et al. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026. Int J Mol Sci. 2016. PMID: 28025562 Free PMC article.
Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of several neurodegenerative disorders, including Alzheimer's disease (AD). ...In parallel, immunocytochemistry analysis has shown that CBD inhibited the expression of GSK3β, a central …
Mesenchymal stem cells (MSCs) have emerged as a promising tool for the treatment of several neurodegenerative disorders, including Alzheimer …
Resolvin E1 Reverses Experimental Periodontitis and Dysbiosis.
Lee CT, Teles R, Kantarci A, Chen T, McCafferty J, Starr JR, Brito LC, Paster BJ, Van Dyke TE. Lee CT, et al. J Immunol. 2016 Oct 1;197(7):2796-806. doi: 10.4049/jimmunol.1600859. Epub 2016 Aug 19. J Immunol. 2016. PMID: 27543615 Free PMC article.
The gingival transcriptome was evaluated by RNA sequencing of mRNA. The composition of the subgingival microbiota was characterized by 16S rDNA sequencing. ...Treatment of established periodontitis with RvE1 reversed bone loss, reversed inflammatory gene e
The gingival transcriptome was evaluated by RNA sequencing of mRNA. The composition of the subgingival microbiota was characte …
Periodontal inflammation: Integrating genes and dysbiosis.
Zhang S, Yu N, Arce RM. Zhang S, et al. Periodontol 2000. 2020 Feb;82(1):129-142. doi: 10.1111/prd.12267. Periodontol 2000. 2020. PMID: 31850627 Free PMC article. Review.
Biofilm bacteria co-evolve and reach a symbiosis with the host on the gingival surface. The disruption of the homeostatic relationship between plaque bacteria and the host can initiate and promote periodontal disease progression. ...Bioinformatics-enabled gene ontol …
Biofilm bacteria co-evolve and reach a symbiosis with the host on the gingival surface. The disruption of the homeostatic relationshi …
Comparative analysis of expression of microbial sensing molecules in mucosal tissues with periodontal disease.
Ebersole JL, Kirakodu S, Novak MJ, Orraca L, Stormberg AJ, Gonzalez-Martinez J, Burgos A, Gonzalez OA. Ebersole JL, et al. Immunobiology. 2019 Mar;224(2):196-206. doi: 10.1016/j.imbio.2018.11.007. Epub 2018 Nov 15. Immunobiology. 2019. PMID: 30470434 Free PMC article.
This study used a nonhuman primate model to evaluate the expression of these sensing molecules in gingival tissues. Macaca mulatta aged 12-24 with a healthy periodontium (n = 13) or periodontitis (n = 11) provided gingival tissues for assessment of naturally- …
This study used a nonhuman primate model to evaluate the expression of these sensing molecules in gingival tissues. Macaca mul …
A combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers.
Richter GM, Kruppa J, Munz M, Wiehe R, Häsler R, Franke A, Martins O, Jockel-Schneider Y, Bruckmann C, Dommisch H, Schaefer AS. Richter GM, et al. Clin Epigenetics. 2019 Jul 22;11(1):105. doi: 10.1186/s13148-019-0697-y. Clin Epigenetics. 2019. PMID: 31331382 Free PMC article.
Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study (EWAS) that aimed to identify biologically active methylation marks of the oral masticatory mucosa that are associated with smoking. ...No …
Cigarette smoke affects gene methylation and expression in various tissues. This is the first epigenome-wide association study …
Prolonged Expansion Induces Spontaneous Neural Progenitor Differentiation from Human Gingiva-Derived Mesenchymal Stem Cells.
Rajan TS, Scionti D, Diomede F, Piattelli A, Bramanti P, Mazzon E, Trubiani O. Rajan TS, et al. Cell Reprogram. 2017 Dec;19(6):389-401. doi: 10.1089/cell.2017.0012. Epub 2017 Oct 23. Cell Reprogram. 2017. PMID: 29058474
In this study, we investigated the spontaneous differentiation efficiency of dental MSCs obtained from human gingiva tissue (hGMSCs) into neural progenitor cells after extended passaging. ...In addition, de novo expression of neural precursor genes, such as NRN1, PH …
In this study, we investigated the spontaneous differentiation efficiency of dental MSCs obtained from human gingiva tissue (hGMSCs) …
MicroRNAs and their target genes in gingival tissues.
Stoecklin-Wasmer C, Guarnieri P, Celenti R, Demmer RT, Kebschull M, Papapanou PN. Stoecklin-Wasmer C, et al. J Dent Res. 2012 Oct;91(10):934-40. doi: 10.1177/0022034512456551. Epub 2012 Aug 9. J Dent Res. 2012. PMID: 22879578 Free PMC article.
Enriched gene sets were grouped in functional categories by DAVID and Ingenuity Pathway Analysis. One hundred fifty-nine miRNAs were significantly differentially expressed between healthy and diseased gingiva. ...This is the first study that concurrently examined mi …
Enriched gene sets were grouped in functional categories by DAVID and Ingenuity Pathway Analysis. One hundred fifty-nine miRNAs were …
Dentistry and OMICS: Transcriptome Dynamics of an Oral Ecosystem as Measured by Changes in Oral Polymorphonuclear Neutrophils in Experimental Gingivitis.
Rijkschroeff P, Schoenmaker T, Caspers M, Verschuren L, Keijser BJF, Nicu EA, Loos BG. Rijkschroeff P, et al. OMICS. 2020 Sep;24(9):531-540. doi: 10.1089/omi.2020.0034. Epub 2020 Jun 19. OMICS. 2020. PMID: 32559408
To the best of our knowledge, this is the first study to report original observations on the transcriptional responses of oPMNs during experimentally induced gingivitis, by temporarily refraining from regular oral care. Oral rinses were prospectively collected at fo …
To the best of our knowledge, this is the first study to report original observations on the transcriptional responses of oPMNs during ex
Transcriptome Analysis of B Cell Immune Functions in Periodontitis: Mucosal Tissue Responses to the Oral Microbiome in Aging.
Ebersole JL, Kirakodu SS, Novak MJ, Orraca L, Martinez JG, Cunningham LL, Thomas MV, Stromberg A, Pandruvada SN, Gonzalez OA. Ebersole JL, et al. Front Immunol. 2016 Jul 18;7:272. doi: 10.3389/fimmu.2016.00272. eCollection 2016. Front Immunol. 2016. PMID: 27486459 Free PMC article.
Evidence has shown activation of T and B cells in gingival tissues in experimental models and in humans diagnosed with periodontitis. ...This report describes our studies evaluating gingival tissue transcriptomes in humans and specifically exploiting the use …
Evidence has shown activation of T and B cells in gingival tissues in experimental models and in humans diagnosed with periodo …
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