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Decoding and unlocking the BCL-2 dependency of cancer cells.

Juin P, Geneste O, Gautier F, Depil S, Campone M. Juin P, et al. Among authors: geneste o. Nat Rev Cancer. 2013 Jul;13(7):455-65. doi: 10.1038/nrc3538. Epub 2013 Jun 20. Nat Rev Cancer. 2013. PMID: 23783119 Review.

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Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer.

Loriot Y, Mordant P, Dugue D, Geneste O, Gombos A, Opolon P, Guegan J, Perfettini JL, Pierre A, Berthier LK, Kroemer G, Soria JC, Depil S, Deutsch E. Loriot Y, et al. Among authors: geneste o. Cell Death Dis. 2014 Sep 18;5(9):e1423. doi: 10.1038/cddis.2014.365. Cell Death Dis. 2014. PMID: 25232677 Free PMC article.

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Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.

Gautier F, Guillemin Y, Cartron PF, Gallenne T, Cauquil N, Le Diguarher T, Casara P, Vallette FM, Manon S, Hickman JA, Geneste O, Juin P. Gautier F, et al. Among authors: geneste o. Mol Cell Biol. 2011 Feb;31(4):832-44. doi: 10.1128/MCB.00161-10. Epub 2010 Dec 20. Mol Cell Biol. 2011. PMID: 21173168 Free PMC article.

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Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.

Némati F, de Montrion C, Lang G, Kraus-Berthier L, Carita G, Sastre-Garau X, Berniard A, Vallerand D, Geneste O, de Plater L, Pierré A, Lockhart B, Desjardins L, Piperno-Neumann S, Depil S, Decaudin D. Némati F, et al. Among authors: geneste o. PLoS One. 2014 Jan 13;9(1):e80836. doi: 10.1371/journal.pone.0080836. eCollection 2014. PLoS One. 2014. PMID: 24454684 Free PMC article.

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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.

Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. Kotschy A, et al. Among authors: geneste o. Nature. 2016 Oct 27;538(7626):477-482. doi: 10.1038/nature19830. Epub 2016 Oct 19. Nature. 2016. PMID: 27760111

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BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/Bcl-X(L).

Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, Geneste O, Kroemer G. Maiuri MC, et al. Among authors: geneste o. Autophagy. 2007 Jul-Aug;3(4):374-6. doi: 10.4161/auto.4237. Epub 2007 Jul 4. Autophagy. 2007. PMID: 17438366

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The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.

Manero F, Gautier F, Gallenne T, Cauquil N, Grée D, Cartron PF, Geneste O, Grée R, Vallette FM, Juin P. Manero F, et al. Among authors: geneste o. Cancer Res. 2006 Mar 1;66(5):2757-64. doi: 10.1158/0008-5472.CAN-05-2097. Cancer Res. 2006. PMID: 16510597

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Shooting at survivors: Bcl-2 family members as drug targets for cancer.

Juin P, Geneste O, Raimbaud E, Hickman JA. Juin P, et al. Among authors: geneste o. Biochim Biophys Acta. 2004 Mar 1;1644(2-3):251-60. doi: 10.1016/j.bbamcr.2003.10.010. Biochim Biophys Acta. 2004. PMID: 14996507 Review. No abstract available.

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[The Bcl-2 family of proteins as drug targets].

Mazars A, Geneste O, Hickman J. Mazars A, et al. Among authors: geneste o. J Soc Biol. 2005;199(3):253-65. doi: 10.1051/jbio:2005027. J Soc Biol. 2005. PMID: 16471266 Review. French.

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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members.

Gallenne T, Gautier F, Oliver L, Hervouet E, Noël B, Hickman JA, Geneste O, Cartron PF, Vallette FM, Manon S, Juin P. Gallenne T, et al. Among authors: geneste o. J Cell Biol. 2009 Apr 20;185(2):279-90. doi: 10.1083/jcb.200809153. J Cell Biol. 2009. PMID: 19380879 Free PMC article.

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