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Decoding and unlocking the BCL-2 dependency of cancer cells.
Juin P, Geneste O, Gautier F, Depil S, Campone M. Juin P, et al. Among authors: geneste o. Nat Rev Cancer. 2013 Jul;13(7):455-65. doi: 10.1038/nrc3538. Epub 2013 Jun 20. Nat Rev Cancer. 2013. PMID: 23783119 Review.
Bax activation by engagement with, then release from, the BH3 binding site of Bcl-xL.
Gautier F, Guillemin Y, Cartron PF, Gallenne T, Cauquil N, Le Diguarher T, Casara P, Vallette FM, Manon S, Hickman JA, Geneste O, Juin P. Gautier F, et al. Among authors: geneste o. Mol Cell Biol. 2011 Feb;31(4):832-44. doi: 10.1128/MCB.00161-10. Epub 2010 Dec 20. Mol Cell Biol. 2011. PMID: 21173168 Free PMC article.
Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.
Némati F, de Montrion C, Lang G, Kraus-Berthier L, Carita G, Sastre-Garau X, Berniard A, Vallerand D, Geneste O, de Plater L, Pierré A, Lockhart B, Desjardins L, Piperno-Neumann S, Depil S, Decaudin D. Némati F, et al. Among authors: geneste o. PLoS One. 2014 Jan 13;9(1):e80836. doi: 10.1371/journal.pone.0080836. eCollection 2014. PLoS One. 2014. PMID: 24454684 Free PMC article.
The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.
Kotschy A, Szlavik Z, Murray J, Davidson J, Maragno AL, Le Toumelin-Braizat G, Chanrion M, Kelly GL, Gong JN, Moujalled DM, Bruno A, Csekei M, Paczal A, Szabo ZB, Sipos S, Radics G, Proszenyak A, Balint B, Ondi L, Blasko G, Robertson A, Surgenor A, Dokurno P, Chen I, Matassova N, Smith J, Pedder C, Graham C, Studeny A, Lysiak-Auvity G, Girard AM, Gravé F, Segal D, Riffkin CD, Pomilio G, Galbraith LC, Aubrey BJ, Brennan MS, Herold MJ, Chang C, Guasconi G, Cauquil N, Melchiore F, Guigal-Stephan N, Lockhart B, Colland F, Hickman JA, Roberts AW, Huang DC, Wei AH, Strasser A, Lessene G, Geneste O. Kotschy A, et al. Among authors: geneste o. Nature. 2016 Oct 27;538(7626):477-482. doi: 10.1038/nature19830. Epub 2016 Oct 19. Nature. 2016. PMID: 27760111
[The Bcl-2 family of proteins as drug targets].
Mazars A, Geneste O, Hickman J. Mazars A, et al. Among authors: geneste o. J Soc Biol. 2005;199(3):253-65. doi: 10.1051/jbio:2005027. J Soc Biol. 2005. PMID: 16471266 Review. French.
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