[Genetic factors as determinants of drug response].
Rev Med Chil. 1989.
PMID: 2519437
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157,106 results
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6
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found by citation matching
Genetic host factors: determinants of drug response.
N Engl J Med. 1985.
PMID: 4010730
No abstract available.
Genetic determinants of antidepressant and antipsychotic drug response.
Eur Arch Psychiatry Clin Neurosci. 2025.
PMID: 39379546
Free PMC article.
Search results
Page 1
Genetic Determinants of Response to Statins in Cardiovascular Diseases.
Curr Cardiol Rev. 2024;20(2):20-28. doi: 10.2174/011573403X267793231220114042.
Curr Cardiol Rev. 2024.
PMID: 38204221
Free PMC article.
Review.
Despite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patients vary in their benefit from therapy and propensity for adverse drug events. Genetic variability in individual responses …
Despite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patient …
Molecular determinants of drug response in TNBC cell lines.
Breast Cancer Res Treat. 2020 Jan;179(2):337-347. doi: 10.1007/s10549-019-05473-9. Epub 2019 Oct 26.
Breast Cancer Res Treat. 2020.
PMID: 31655920
Free PMC article.
METHODS: Using 23 TNBC cell lines, drug sensitivity scores (DSS(3)) were determined using a panel of investigational drugs and drugs approved for other indications. ...CONCLUSIONS: These findings demonstrate an integrated method to identify biomarkers of drug …
METHODS: Using 23 TNBC cell lines, drug sensitivity scores (DSS(3)) were determined using a panel of investigational drugs and …
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Nat Med. 2019 Mar;25(3):462-469. doi: 10.1038/s41591-019-0349-y. Epub 2019 Feb 11.
Nat Med. 2019.
PMID: 30742119
Free PMC article.
Immune checkpoint inhibitors have been successful across several tumor types; however, their efficacy has been uncommon and unpredictable in glioblastomas (GBM), where <10% of patients show long-term responses. To understand the molecular determinants of immunoth …
Immune checkpoint inhibitors have been successful across several tumor types; however, their efficacy has been uncommon and unpredictable in …
Genetic determinants of drug response in heart failure.
Curr Cardiol Rep. 2008 May;10(3):176-81. doi: 10.1007/s11886-008-0031-3.
Curr Cardiol Rep. 2008.
PMID: 18489860
Review.
Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. ...Technologic advances will soon allow population-based …
Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand …
Epigenetic mechanisms in breast cancer therapy and resistance.
Nat Commun. 2021 Mar 19;12(1):1786. doi: 10.1038/s41467-021-22024-3.
Nat Commun. 2021.
PMID: 33741974
Free PMC article.
Review.
Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adoption in the 1940s as an ablative therapy. Unfortunately, therapeutic resistance arises, leading to disease recurrence and relapse. ...Here, we will discuss how …
Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adoption in the 1940s as …
Pharmacogenetics.
Br Med Bull. 1999;55(2):366-86. doi: 10.1258/0007142991902439.
Br Med Bull. 1999.
PMID: 10723863
Review.
It is now clear that much of the observed variability in drug response has a genetic basis, arising as a result of genetically-determined differences in drug absorption, disposition, metabolism or excretion. ...A detailed knowledge of the …
It is now clear that much of the observed variability in drug response has a genetic basis, arising as a result of g …
Prediction of response to drug therapy in psychiatric disorders.
Open Biol. 2018 May;8(5):180031. doi: 10.1098/rsob.180031.
Open Biol. 2018.
PMID: 29794033
Free PMC article.
Review.
In the last 10 years, the Food and Drug Administration (FDA) has approved several genetically pre-screened drugs labelled as pharmacogenomics in the fields of oncology, pulmonary medicine, gastroenterology, haematology, neurology, rheumatology and even psychiatry. . …
In the last 10 years, the Food and Drug Administration (FDA) has approved several genetically pre-screened drugs labelled as p …
MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
Plant Cell. 2017 Aug;29(8):1883-1906. doi: 10.1105/tpc.16.00953. Epub 2017 Jul 21.
Plant Cell. 2017.
PMID: 28733419
Free PMC article.
We show that the basic helix-loop-helix transcription factor (TF) MYC2 in tomato (Solanum lycopersicum) acts downstream of the JA receptor to orchestrate JA-mediated activation of both the wounding and pathogen responses. Using chromatin immunoprecipitation sequencing (ChI …
We show that the basic helix-loop-helix transcription factor (TF) MYC2 in tomato (Solanum lycopersicum) acts downstream of the JA receptor t …
Genetic determinants of drug responsiveness and drug interactions.
Ther Drug Monit. 1998 Oct;20(5):517-24. doi: 10.1097/00007691-199810000-00012.
Ther Drug Monit. 1998.
PMID: 9780128
Review.
This has been supplemented in recent years by the availability of genetic analysis and the identification of specific alleles that are associated with altered (i.e., reduced, deficient, or increased) enzyme activity. The potential of genotyping to predict pharmacody …
This has been supplemented in recent years by the availability of genetic analysis and the identification of specific alleles …
The impact of genetic factors on response to anaesthetics.
Adv Med Sci. 2013;58(1):9-14. doi: 10.2478/v10039-012-0065-z.
Adv Med Sci. 2013.
PMID: 23640947
Review.
In recent years, exceptional progress has been observed in pharmacogenetics, i.e. investigations of inherited conditioning of the organism's response to drugs or xenobiotics. On the other hand, modern molecular biology techniques have been implemented, making it possible t …
In recent years, exceptional progress has been observed in pharmacogenetics, i.e. investigations of inherited conditioning of the organism's …
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