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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 2
1966 2
1967 3
1968 8
1969 6
1970 10
1971 14
1972 21
1973 29
1974 39
1975 82
1976 85
1977 60
1978 74
1979 95
1980 107
1981 99
1982 134
1983 175
1984 224
1985 205
1986 282
1987 350
1988 425
1989 508
1990 673
1991 813
1992 990
1993 1165
1994 1360
1995 1555
1996 1719
1997 1961
1998 2034
1999 2507
2000 3007
2001 3377
2002 3661
2003 3991
2004 4265
2005 4729
2006 5088
2007 5463
2008 5678
2009 5698
2010 6191
2011 6986
2012 7177
2013 7267
2014 7542
2015 7742
2016 7461
2017 7203
2018 6807
2019 6790
2020 6709
2021 6358
2022 4460
2023 4174
2024 6867
2025 9401
2026 3851

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157,106 results

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6 articles found by citation matching

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Page 1
Genetic Determinants of Response to Statins in Cardiovascular Diseases.
Ghorbannezhad G, Mehrabadi S, Golampour-Shamkani N, Barjasteh A, Etesamizadeh P, Tayyebi M, Khazaei M, Hassanian SM, Ferns GA, Avan A. Ghorbannezhad G, et al. Curr Cardiol Rev. 2024;20(2):20-28. doi: 10.2174/011573403X267793231220114042. Curr Cardiol Rev. 2024. PMID: 38204221 Free PMC article. Review.
Despite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patients vary in their benefit from therapy and propensity for adverse drug events. Genetic variability in individual responses
Despite extensive efforts to identify patients with cardiovascular disease (CVD) who could most benefit from the treatment approach, patient …
Molecular determinants of drug response in TNBC cell lines.
Merrill NM, Lachacz EJ, Vandecan NM, Ulintz PJ, Bao L, Lloyd JP, Yates JA, Morikawa A, Merajver SD, Soellner MB. Merrill NM, et al. Breast Cancer Res Treat. 2020 Jan;179(2):337-347. doi: 10.1007/s10549-019-05473-9. Epub 2019 Oct 26. Breast Cancer Res Treat. 2020. PMID: 31655920 Free PMC article.
METHODS: Using 23 TNBC cell lines, drug sensitivity scores (DSS(3)) were determined using a panel of investigational drugs and drugs approved for other indications. ...CONCLUSIONS: These findings demonstrate an integrated method to identify biomarkers of drug
METHODS: Using 23 TNBC cell lines, drug sensitivity scores (DSS(3)) were determined using a panel of investigational drugs and …
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Zhao J, Chen AX, Gartrell RD, Silverman AM, Aparicio L, Chu T, Bordbar D, Shan D, Samanamud J, Mahajan A, Filip I, Orenbuch R, Goetz M, Yamaguchi JT, Cloney M, Horbinski C, Lukas RV, Raizer J, Rae AI, Yuan J, Canoll P, Bruce JN, Saenger YM, Sims P, Iwamoto FM, Sonabend AM, Rabadan R. Zhao J, et al. Nat Med. 2019 Mar;25(3):462-469. doi: 10.1038/s41591-019-0349-y. Epub 2019 Feb 11. Nat Med. 2019. PMID: 30742119 Free PMC article.
Immune checkpoint inhibitors have been successful across several tumor types; however, their efficacy has been uncommon and unpredictable in glioblastomas (GBM), where <10% of patients show long-term responses. To understand the molecular determinants of immunoth …
Immune checkpoint inhibitors have been successful across several tumor types; however, their efficacy has been uncommon and unpredictable in …
Genetic determinants of drug response in heart failure.
Lowes BD, Buttrick PM. Lowes BD, et al. Curr Cardiol Rep. 2008 May;10(3):176-81. doi: 10.1007/s11886-008-0031-3. Curr Cardiol Rep. 2008. PMID: 18489860 Review.
Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand interactions have the potential to modify drug response and safety. ...Technologic advances will soon allow population-based …
Heart failure management is complex and costly. Genetic variations that alter drug absorption, metabolism, and receptor-ligand …
Epigenetic mechanisms in breast cancer therapy and resistance.
Garcia-Martinez L, Zhang Y, Nakata Y, Chan HL, Morey L. Garcia-Martinez L, et al. Nat Commun. 2021 Mar 19;12(1):1786. doi: 10.1038/s41467-021-22024-3. Nat Commun. 2021. PMID: 33741974 Free PMC article. Review.
Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adoption in the 1940s as an ablative therapy. Unfortunately, therapeutic resistance arises, leading to disease recurrence and relapse. ...Here, we will discuss how …
Endocrine therapy has proven successful in the treatment of hormone-responsive breast cancer since its early adoption in the 1940s as …
Pharmacogenetics.
Wolf CR, Smith G. Wolf CR, et al. Br Med Bull. 1999;55(2):366-86. doi: 10.1258/0007142991902439. Br Med Bull. 1999. PMID: 10723863 Review.
It is now clear that much of the observed variability in drug response has a genetic basis, arising as a result of genetically-determined differences in drug absorption, disposition, metabolism or excretion. ...A detailed knowledge of the …
It is now clear that much of the observed variability in drug response has a genetic basis, arising as a result of g
Prediction of response to drug therapy in psychiatric disorders.
Stern S, Linker S, Vadodaria KC, Marchetto MC, Gage FH. Stern S, et al. Open Biol. 2018 May;8(5):180031. doi: 10.1098/rsob.180031. Open Biol. 2018. PMID: 29794033 Free PMC article. Review.
In the last 10 years, the Food and Drug Administration (FDA) has approved several genetically pre-screened drugs labelled as pharmacogenomics in the fields of oncology, pulmonary medicine, gastroenterology, haematology, neurology, rheumatology and even psychiatry. . …
In the last 10 years, the Food and Drug Administration (FDA) has approved several genetically pre-screened drugs labelled as p …
MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
Du M, Zhao J, Tzeng DTW, Liu Y, Deng L, Yang T, Zhai Q, Wu F, Huang Z, Zhou M, Wang Q, Chen Q, Zhong S, Li CB, Li C. Du M, et al. Plant Cell. 2017 Aug;29(8):1883-1906. doi: 10.1105/tpc.16.00953. Epub 2017 Jul 21. Plant Cell. 2017. PMID: 28733419 Free PMC article.
We show that the basic helix-loop-helix transcription factor (TF) MYC2 in tomato (Solanum lycopersicum) acts downstream of the JA receptor to orchestrate JA-mediated activation of both the wounding and pathogen responses. Using chromatin immunoprecipitation sequencing (ChI …
We show that the basic helix-loop-helix transcription factor (TF) MYC2 in tomato (Solanum lycopersicum) acts downstream of the JA receptor t …
Genetic determinants of drug responsiveness and drug interactions.
Caraco Y. Caraco Y. Ther Drug Monit. 1998 Oct;20(5):517-24. doi: 10.1097/00007691-199810000-00012. Ther Drug Monit. 1998. PMID: 9780128 Review.
This has been supplemented in recent years by the availability of genetic analysis and the identification of specific alleles that are associated with altered (i.e., reduced, deficient, or increased) enzyme activity. The potential of genotyping to predict pharmacody …
This has been supplemented in recent years by the availability of genetic analysis and the identification of specific alleles …
The impact of genetic factors on response to anaesthetics.
Mikstacki A, Skrzypczak-Zielinska M, Tamowicz B, Zakerska-Banaszak O, Szalata M, Slomski R. Mikstacki A, et al. Adv Med Sci. 2013;58(1):9-14. doi: 10.2478/v10039-012-0065-z. Adv Med Sci. 2013. PMID: 23640947 Review.
In recent years, exceptional progress has been observed in pharmacogenetics, i.e. investigations of inherited conditioning of the organism's response to drugs or xenobiotics. On the other hand, modern molecular biology techniques have been implemented, making it possible t …
In recent years, exceptional progress has been observed in pharmacogenetics, i.e. investigations of inherited conditioning of the organism's …
157,106 results
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