Genetic Determinants of P2Y12 Inhibitors and Clinical Implications.
Interv Cardiol Clin. 2017.
PMID: 27886818
Free PMC article.
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Genetic Determinants of P2Y12 Inhibitors and Clinical Implications.
Interv Cardiol Clin. 2017 Jan;6(1):141-149. doi: 10.1016/j.iccl.2016.08.010.
Interv Cardiol Clin. 2017.
PMID: 27886818
Free PMC article.
Review.
Guidelines recommend consideration of prasugrel or ticagrelor in these patients. A clinical trial examining outcomes with CYP2C19 genotype-guided antiplatelet therapy is ongoing. In the meantime, based on the evidence available to date, several institutions have started …
Guidelines recommend consideration of prasugrel or ticagrelor in these patients. A clinical trial examining outcomes with CYP2C19 gen …
Role of genetic testing in patients undergoing percutaneous coronary intervention.
Expert Rev Clin Pharmacol. 2018 Feb;11(2):151-164. doi: 10.1080/17512433.2017.1353909. Epub 2017 Oct 12.
Expert Rev Clin Pharmacol. 2018.
PMID: 28689434
Free PMC article.
Review.
Areas covered: The present manuscript provides an overview of genetic factors associated with response profiles to platelet P2Y(12) receptor inhibitors and their clinical implications, as well as the most recent developments and future co …
Areas covered: The present manuscript provides an overview of genetic factors associated with response profiles to platelet P2Y …
Expression and localization of purinergic P2Y(12) receptor in human nasal mucosa.
Allergol Int. 2013 Jun;62(2):239-44. doi: 10.2332/allergolint.12-OA-0496. Epub 2013 Apr 25.
Allergol Int. 2013.
PMID: 23612493
Free article.
The expression of P2Y12 receptor was evaluated by RT-PCR, western blotting, and immunohistochemical analysis. RESULTS: RT-PCR analysis of total RNA extracted from human nasal turbinate, primary cultured human nasal epithelial cells and nasal vascular endothelial cel …
The expression of P2Y12 receptor was evaluated by RT-PCR, western blotting, and immunohistochemical analysis. RESULTS: RT-PCR anal …
Proton Pump Inhibitors in Cardiovascular Disease: Drug Interactions with Antiplatelet Drugs.
Adv Exp Med Biol. 2017;906:325-350. doi: 10.1007/5584_2016_124.
Adv Exp Med Biol. 2017.
PMID: 27628008
Review.
Aspirin and P2Y(12) receptor antagonists are widely used across the spectrum of cardiovascular diseases. ...The antiplatelet effect of the new P2Y(12) receptor antagonists, ticagrelor and prasugrel, seems less influenced by PPI co-treatme …
Aspirin and P2Y(12) receptor antagonists are widely used across the spectrum of cardiovascular diseases. ...The antipla …
P2 receptors, platelet function and pharmacological implications.
Thromb Haemost. 2008 Mar;99(3):466-72. doi: 10.1160/TH07-11-0673.
Thromb Haemost. 2008.
PMID: 18327393
Review.
The ATP-gated cation channel P2X(1) and the two G protein-coupled ADP receptors, P2Y(1) and P2Y(12), selectively contribute to platelet aggregation and formation of a thrombus. Owing to its central role in the growth and stabilization of a thrombus, the P2 …
The ATP-gated cation channel P2X(1) and the two G protein-coupled ADP receptors, P2Y(1) and P2Y(12), selectively contri …
Response variability to clopidogrel: is tailored treatment, based on laboratory testing, the right solution?
J Thromb Haemost. 2012 Mar;10(3):327-36. doi: 10.1111/j.1538-7836.2011.04602.x.
J Thromb Haemost. 2012.
PMID: 22221409
Free article.
Review.
Clopidogrel is an antithrombotic prodrug, whose active metabolite inhibits platelet function by irreversibly binding to the platelet receptor for adenosine diphosphate, P2Y(12). Wide inter-individual variability of response to clopidogrel has been reported in severa …
Clopidogrel is an antithrombotic prodrug, whose active metabolite inhibits platelet function by irreversibly binding to the platelet recepto …
Circulating MicroRNA Levels Indicate Platelet and Leukocyte Activation in Endotoxemia Despite Platelet P2Y12 Inhibition.
Int J Mol Sci. 2020 Apr 21;21(8):2897. doi: 10.3390/ijms21082897.
Int J Mol Sci. 2020.
PMID: 32326325
Free PMC article.
There is evidence for the effects of platelet inhibition on innate immune activation. Circulating microRNAs (miRNAs) have been implicated as markers of platelet and leukocyte activation. In the present study, we assessed the effects of P2Y(12) inhibitors …
There is evidence for the effects of platelet inhibition on innate immune activation. Circulating microRNAs (miRNAs) have been implicated …
Influence of CYP450 Enzymes, CES1, PON1, ABCB1, and P2RY12 Polymorphisms on Clopidogrel Response in Patients Subjected to a Percutaneous Neurointervention.
Clin Ther. 2019 Jun;41(6):1199-1212.e2. doi: 10.1016/j.clinthera.2019.04.037. Epub 2019 May 23.
Clin Ther. 2019.
PMID: 31128980
Free article.
METHODS: This observational retrospective study assessed the antiplatelet response and the prevalence of hemorrhagic or ischemic events after percutaneous neurointervention in clopidogrel-treated patients, related to 35 polymorphisms in the genes encoding the clopidogrel-metaboli …
METHODS: This observational retrospective study assessed the antiplatelet response and the prevalence of hemorrhagic or ischemic events afte …
P2Y12 polymorphisms and antiplatelet effects of aspirin in patients with coronary artery disease.
Br J Clin Pharmacol. 2008 Apr;65(4):540-7. doi: 10.1111/j.1365-2125.2007.03044.x. Epub 2007 Nov 8.
Br J Clin Pharmacol. 2008.
PMID: 17995973
Free PMC article.
AIMS: Recently, two genetic polymorphisms of the platelet ADP receptor P2Y(12) (haplotypes H2 and 34T) have been implicated in increased platelet aggregation and atherothrombotic risk. ...METHODS: Platelet aggregation was studied in platelet-rich plasm …
AIMS: Recently, two genetic polymorphisms of the platelet ADP receptor P2Y(12) (haplotypes H2 and 34T) have been imp …
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