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Genetic variation in STAT4 predicts response to interferon-alpha therapy for hepatitis B e antigen-positive chronic hepatitis B.
Jiang DK, Wu X, Qian J, Ma XP, Yang J, Li Z, Wang R, Sun L, Liu F, Zhang P, Zhu X, Wu J, Chen K, Conran C, Zheng SL, Lu D, Yu L, Liu Y, Xu J. Jiang DK, et al. Hepatology. 2016 Apr;63(4):1102-11. doi: 10.1002/hep.28423. Epub 2016 Feb 19. Hepatology. 2016. PMID: 26704347
Interferon (IFN)-alpha is a first-line therapy for chronic hepatitis B (CHB) patients but only initiates a response in a minority of patients. A genetic variant, rs7574865 in STAT4, was recently reported to be associated with risk …
Interferon (IFN)-alpha is a first-line therapy for chronic hepatitis B (CHB) patients but only initiates a re …
TRIM26 inhibits hepatitis B virus replication by promoting HBx degradation and TRIM26 genetic polymorphism predicts PegIFNalpha treatment response of HBeAg-positive chronic hepatitis B Patients.
Luo M, Hou J, Mai H, Chen J, Chen H, Zhou B, Hou J, Jiang DK. Luo M, et al. Aliment Pharmacol Ther. 2022 Sep;56(5):878-889. doi: 10.1111/apt.17124. Epub 2022 Jul 24. Aliment Pharmacol Ther. 2022. PMID: 35872575
AIMS: To manifest the role of TRIM26 on HBV replication and explore if there are single-nucleotide polymorphisms (SNPs) in TRIM26 associated with response to pegylated interferon-alpha (PegIFNalpha) treatment in patients with chronic hepatitis B (CHB). …
AIMS: To manifest the role of TRIM26 on HBV replication and explore if there are single-nucleotide polymorphisms (SNPs) in TRIM26 associated …