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Genetic architecture of asthma in African American patients.
Chang X, March M, Mentch F, Qu H, Liu Y, Glessner J, Sleiman P, Hakonarson H. Chang X, et al. J Allergy Clin Immunol. 2023 Apr;151(4):1132-1136. doi: 10.1016/j.jaci.2022.09.001. Epub 2022 Sep 8. J Allergy Clin Immunol. 2023. PMID: 36089080 Free PMC article.
Although more than 100 loci were reported through the genome-wide association study of European populations, the genetic underpinning of asthma in African American individuals remains largely elusive. OBJECTIVE: We aimed to identify genetic loci …
Although more than 100 loci were reported through the genome-wide association study of European populations, the genetic underpinning …
Whole-Genome Sequencing Identifies Novel Functional Loci Associated with Lung Function in Puerto Rican Youth.
Lee EY, Mak ACY, Hu D, Sajuthi S, White MJ, Keys KL, Eckalbar W, Bonser L, Huntsman S, Urbanek C, Eng C, Jain D, Abecasis G, Kang HM, Germer S, Zody MC, Nickerson DA, Erle D, Ziv E, Rodriguez-Santana J, Seibold MA, Burchard EG. Lee EY, et al. Am J Respir Crit Care Med. 2020 Oct 1;202(7):962-972. doi: 10.1164/rccm.202002-0351OC. Am J Respir Crit Care Med. 2020. PMID: 32459537 Free PMC article.
Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%); however, the etiology is uncertain.Objectives: In this study, we sought to uncover the genetic architecture of lung function in Puerto Rican youth with and wit …
Rationale: Puerto Ricans have the highest childhood asthma prevalence in the United States (23.6%); however, the etiology is uncertai …