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Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Abeta, tau, immunity and lipid processing.
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, Badarinarayan N, Jakobsdottir J, Hamilton-Nelson KL, Moreno-Grau S, Olaso R, Raybould R, Chen Y, Kuzma AB, Hiltunen M, Morgan T, Ahmad S, Vardarajan BN, Epelbaum J, Hoffmann P, Boada M, Beecham GW, Garnier JG, Harold D, Fitzpatrick AL, Valladares O, Moutet ML, Gerrish A, Smith AV, Qu L, Bacq D, Denning N, Jian X, Zhao Y, Del Zompo M, Fox NC, Choi SH, Mateo I, Hughes JT, Adams HH, Malamon J, Sanchez-Garcia F, Patel Y, Brody JA, Dombroski BA, Naranjo MCD, Daniilidou M, Eiriksdottir G, Mukherjee S, Wallon D, Uphill J, Aspelund T, Cantwell LB, Garzia F, Galimberti D, Hofer E, Butkiewicz M, Fin B, Scarpini E, Sarnowski C, Bush WS, Meslage S, Kornhuber J, White CC, Song Y, Barber RC, Engelborghs S, Sordon S, Voijnovic D, Adams PM, Vandenberghe R, Mayhaus M, Cupples LA, Albert MS, De Deyn PP, Gu W, Himali JJ, Beekly D, Squassina A, Hartmann AM, Orellana A, Blacker D, Rodriguez-Rodriguez E, Lovestone S, Garcia ME, Doody RS, Munoz-Fernadez C, Sussams R, Lin H, Fairchild TJ, Benito YA, Holmes C, Karamujić-Čomić H, Fr… See abstract for full author list ➔ Kunkle BW, et al. Nat Genet. 2019 Mar;51(3):414-430. doi: 10.1038/s41588-019-0358-2. Epub 2019 Feb 28. Nat Genet. 2019. PMID: 30820047 Free PMC article.
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. ...Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, …
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by ge
Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.
Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB; EPAD Study Group; Investigators from ACT; Investigators from ROS; Investigators from MAP; Investigators from ADNI; Investigators from the University of Pittsburgh ADRC; Crane PK. Mukherjee S, et al. Mol Psychiatry. 2020 Nov;25(11):2942-2951. doi: 10.1038/s41380-018-0298-8. Epub 2018 Dec 4. Mol Psychiatry. 2020. PMID: 30514930 Free PMC article.
Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important for personalized medicine. ...We assigned people to cognitively defined subgroups on the basis of relative performance in mem …
Categorizing people with late-onset Alzheimer's disease into biologically coherent subgroups is important …
Correction: Genetic data and cognitively defined late-onset Alzheimer's disease subgroups.
Mukherjee S, Mez J, Trittschuh EH, Saykin AJ, Gibbons LE, Fardo DW, Wessels M, Bauman J, Moore M, Choi SE, Gross AL, Rich J, Louden DKN, Sanders RE, Grabowski TJ, Bird TD, McCurry SM, Snitz BE, Kamboh MI, Lopez OL, De Jager PL, Bennett DA, Keene CD, Larson EB; EPAD Study Group; Investigators from ACT; Investigators from ROS; Investigators from MAP; Investigators from ADNI; Investigators from the University of Pittsburgh ADRC; Crane PK. Mukherjee S, et al. Mol Psychiatry. 2020 Nov;25(11):3100. doi: 10.1038/s41380-019-0348-x. Mol Psychiatry. 2020. PMID: 30647434 Free PMC article.
Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition.
Mosconi L, Berti V, Dyke J, Schelbaum E, Jett S, Loughlin L, Jang G, Rahman A, Hristov H, Pahlajani S, Andrews R, Matthews D, Etingin O, Ganzer C, de Leon M, Isaacson R, Brinton RD. Mosconi L, et al. Sci Rep. 2021 Jun 9;11(1):10867. doi: 10.1038/s41598-021-90084-y. Sci Rep. 2021. PMID: 34108509 Free PMC article.
Brain biomarkers largely stabilized post-menopause, and gray matter volume (GMV) recovered in key brain regions for cognitive aging. Notably, GMV recovery and in vivo brain mitochondria ATP production correlated with preservation of cognitive performance post-menopa …
Brain biomarkers largely stabilized post-menopause, and gray matter volume (GMV) recovered in key brain regions for cognitive aging. …
Associations Between Depression, Traumatic Brain Injury, and Cognitively-Defined Late-Onset Alzheimer's Disease Subgroups.
Bauman J, Gibbons LE, Moore M, Mukherjee S, McCurry SM, McCormick W, Bowen JD, Trittschuh E, Glymour M, Mez J, Saykin AJ, Dams-O'Conner K, Bennett DA, Larson EB, Crane PK; Executive Prominent AD (EPAD) investigators. Bauman J, et al. J Alzheimers Dis. 2019;70(2):611-619. doi: 10.3233/JAD-181212. J Alzheimers Dis. 2019. PMID: 31256124 Free PMC article.
BACKGROUND: There is considerable heterogeneity in clinical presentation among people with late-onset Alzheimer's disease (LOAD). We have categorized people with LOAD into subgroups based on relative impairments across cognitive domains. …
BACKGROUND: There is considerable heterogeneity in clinical presentation among people with late-onset Alzheimer's
Incidence of cognitively defined late-onset Alzheimer's dementia subgroups from a prospective cohort study.
Crane PK, Trittschuh E, Mukherjee S, Saykin AJ, Sanders RE, Larson EB, McCurry SM, McCormick W, Bowen JD, Grabowski T, Moore M, Bauman J, Gross AL, Keene CD, Bird TD, Gibbons LE, Mez J; Executive Prominent Alzheimer's Disease: Genetics and Risk Factors (EPAD:GRF) Investigators. Crane PK, et al. Alzheimers Dement. 2017 Dec;13(12):1307-1316. doi: 10.1016/j.jalz.2017.04.011. Epub 2017 Jun 15. Alzheimers Dement. 2017. PMID: 28623677 Free PMC article.
INTRODUCTION: There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia. METHODS: We analyzed cognitive data from people with incident late-onset Alzheimer's dementia from …
INTRODUCTION: There may be biologically relevant heterogeneity within typical late-onset Alzheimer's dementia. M …
Comparing cortical signatures of atrophy between late-onset and autosomal dominant Alzheimer disease.
Dincer A, Gordon BA, Hari-Raj A, Keefe SJ, Flores S, McKay NS, Paulick AM, Shady Lewis KE, Feldman RL, Hornbeck RC, Allegri R, Ances BM, Berman SB, Brickman AM, Brooks WS, Cash DM, Chhatwal JP, Farlow MR, la Fougère C, Fox NC, Fulham MJ, Jack CR Jr, Joseph-Mathurin N, Karch CM, Lee A, Levin J, Masters CL, McDade EM, Oh H, Perrin RJ, Raji C, Salloway SP, Schofield PR, Su Y, Villemagne VL, Wang Q, Weiner MW, Xiong C, Yakushev I, Morris JC, Bateman RJ, L S Benzinger T; Dominantly Inherited Alzheimer Network DIAN. Dincer A, et al. Neuroimage Clin. 2020;28:102491. doi: 10.1016/j.nicl.2020.102491. Epub 2020 Nov 5. Neuroimage Clin. 2020. PMID: 33395982 Free PMC article.
Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may offer improved sensitivity to early AD compared to hippocampal volume or mesial temporal lobe alone. Since late-onset Alzheim
Defining a signature of cortical regions of interest preferentially affected by Alzheimer disease (AD) pathology may of
Screening of Early and Late Onset Alzheimer's Disease Genetic Risk Factors in a Cohort of Dementia Patients from Liguria, Italy.
Ferrari R, Ferrara M, Alinani A, Sutton RB, Famà F, Picco A, Rodriguez G, Nobili F, Momeni P. Ferrari R, et al. Curr Alzheimer Res. 2015;12(8):802-12. doi: 10.2174/1567205012666150710114751. Curr Alzheimer Res. 2015. PMID: 26159191
Cohorts from a defined geographical area enable ad hoc genotype-phenotype correlation studies providing novel and unique insight into disease. We analysed genetic risk factors associated with early and late onset Alzheimer's dis
Cohorts from a defined geographical area enable ad hoc genotype-phenotype correlation studies providing novel and unique insight into …
Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology.
Monsell SE, Mock C, Fardo DW, Bertelsen S, Cairns NJ, Roe CM, Ellingson SR, Morris JC, Goate AM, Kukull WA. Monsell SE, et al. Alzheimer Dis Assoc Disord. 2017 Jul-Sep;31(3):232-238. doi: 10.1097/WAD.0000000000000179. Alzheimer Dis Assoc Disord. 2017. PMID: 27849641 Free PMC article.
OBJECTIVE: The objective was to determine whether symptomatic and asymptomatic persons with Alzheimer disease (AD) neuropathology have different allele counts for single-nucleotide polymorphisms that have been associated with clinical late-onset AD. ME …
OBJECTIVE: The objective was to determine whether symptomatic and asymptomatic persons with Alzheimer disease (AD) neuropathol …
APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.
Farmer BC, Williams HC, Devanney NA, Piron MA, Nation GK, Carter DJ, Walsh AE, Khanal R, Young LEA, Kluemper JC, Hernandez G, Allenger EJ, Mooney R, Golden LR, Smith CT, Brandon JA, Gupta VA, Kern PA, Gentry MS, Morganti JM, Sun RC, Johnson LA. Farmer BC, et al. Mol Neurodegener. 2021 Sep 6;16(1):62. doi: 10.1186/s13024-021-00483-y. Mol Neurodegener. 2021. PMID: 34488832 Free PMC article.
BACKGROUND: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer's disease (AD), as well as in young cognitively normal carriers of the epsilon4 allele of Apolipoprotein E (APOE), the strongest genetic predictor …
BACKGROUND: Cerebral glucose hypometabolism is consistently observed in individuals with Alzheimer's disease (AD), as w …
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