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Genetic sharing and heritability of paediatric age of onset autoimmune diseases.
Li YR, Zhao SD, Li J, Bradfield JP, Mohebnasab M, Steel L, Kobie J, Abrams DJ, Mentch FD, Glessner JT, Guo Y, Wei Z, Connolly JJ, Cardinale CJ, Bakay M, Li D, Maggadottir SM, Thomas KA, Qui H, Chiavacci RM, Kim CE, Wang F, Snyder J, Flatø B, Førre Ø, Denson LA, Thompson SD, Becker ML, Guthery SL, Latiano A, Perez E, Resnick E, Strisciuglio C, Staiano A, Miele E, Silverberg MS, Lie BA, Punaro M, Russell RK, Wilson DC, Dubinsky MC, Monos DS, Annese V, Munro JE, Wise C, Chapel H, Cunningham-Rundles C, Orange JS, Behrens EM, Sullivan KE, Kugathasan S, Griffiths AM, Satsangi J, Grant SFA, Sleiman PMA, Finkel TH, Polychronakos C, Baldassano RN, Luning Prak ET, Ellis JA, Li H, Keating BJ, Hakonarson H. Li YR, et al. Nat Commun. 2015 Oct 9;6:8442. doi: 10.1038/ncomms9442. Nat Commun. 2015. PMID: 26450413 Free PMC article.
Autoimmune diseases (AIDs) are polygenic diseases affecting 7-10% of the population in the Western Hemisphere with few effective therapies. ...Variations across the MHC strongly contribute to SNP-h(2) in T1D and JIA, but does not significantly contribute to t
Autoimmune diseases (AIDs) are polygenic diseases affecting 7-10% of the population in the Western Hemisphere with few
Genomics of Systemic Lupus Erythematosus: Insights Gained by Studying Monogenic Young-Onset Systemic Lupus Erythematosus.
Hiraki LT, Silverman ED. Hiraki LT, et al. Rheum Dis Clin North Am. 2017 Aug;43(3):415-434. doi: 10.1016/j.rdc.2017.04.005. Rheum Dis Clin North Am. 2017. PMID: 28711143 Review.
Genome-wide association studies have identified multiple susceptibility loci, but these explain a fraction of the estimated heritability. This is partly because within the broad spectrum of SLE are monogenic diseases that tend to cluster in patients with young ag
Genome-wide association studies have identified multiple susceptibility loci, but these explain a fraction of the estimated heritability
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups.
Wang YF, Zhang Y, Lin Z, Zhang H, Wang TY, Cao Y, Morris DL, Sheng Y, Yin X, Zhong SL, Gu X, Lei Y, He J, Wu Q, Shen JJ, Yang J, Lam TH, Lin JH, Mai ZM, Guo M, Tang Y, Chen Y, Song Q, Ban B, Mok CC, Cui Y, Lu L, Shen N, Sham PC, Lau CS, Smith DK, Vyse TJ, Zhang X, Lau YL, Yang W. Wang YF, et al. Nat Commun. 2021 Feb 3;12(1):772. doi: 10.1038/s41467-021-21049-y. Nat Commun. 2021. PMID: 33536424 Free PMC article.
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, severity and age of onset among different ancestral groups. Previous genetic studies have focused more on European popula …
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high heritability, shows differences in prevalence, se …