Genetic susceptibility for autoimmune diseases and white blood cell count.
Sci Rep. 2023.
PMID: 37041293
Free PMC article.
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Genetic susceptibility for autoimmune diseases and white blood cell count.
Sci Rep. 2023 Apr 11;13(1):5852. doi: 10.1038/s41598-023-32799-8.
Sci Rep. 2023.
PMID: 37041293
Free PMC article.
Some autoimmune (AI) conditions affect white blood cell (WBC) counts. Whether a genetic predisposition to AI disease associates with WBC counts in populations expected to have low numbers of AI cases is not known. We developed g …
Some autoimmune (AI) conditions affect white blood cell (WBC) counts. Whether a genetic predisposition …
The Effect of Peripheral Immune Cell Counts on the Risk of Multiple Sclerosis: A Mendelian Randomization Study.
Front Immunol. 2022 May 10;13:867693. doi: 10.3389/fimmu.2022.867693. eCollection 2022.
Front Immunol. 2022.
PMID: 35619713
Free PMC article.
CONCLUSIONS: These findings show that the genetic predisposition to higher peripheral immune cell counts can exert a causal effect on MS risk, which confirms the crucial role played by peripheral immunity in MS. Particularly, the causal association between NK …
CONCLUSIONS: These findings show that the genetic predisposition to higher peripheral immune cell counts can exert a ca …
White blood cell mitochondrial DNA copy number is decreased in rheumatoid arthritis and linked with risk factors. A twin study.
J Autoimmun. 2019 Jan;96:142-146. doi: 10.1016/j.jaut.2018.09.008. Epub 2018 Oct 14.
J Autoimmun. 2019.
PMID: 30327147
Low mitochondrial DNA copy number (mtDNA CN) has been associated with e.g. cancer, cardiovascular and autoimmune diseases. We aimed to study a potential association between mtDNA CN and rheumatoid arthritis (RA). The relative quantity of mitochondrial DNA compared t …
Low mitochondrial DNA copy number (mtDNA CN) has been associated with e.g. cancer, cardiovascular and autoimmune diseases. We …
Genetic polymorphisms and surface expression of CTLA-4 and PD-1 on T cells of silica-exposed workers.
Int J Hyg Environ Health. 2012 Nov;215(6):562-9. doi: 10.1016/j.ijheh.2011.10.010. Epub 2011 Dec 5.
Int J Hyg Environ Health. 2012.
PMID: 22153879
Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid arthritis and systemic lupus erythematosus. ...Our findings provide evidence for the association of silica exposure and the maintenance of …
Exposure to silica dust has been examined as a possible risk factor for autoimmune diseases, including scleroderma, rheumatoid …
Clinical characteristics and genetic analysis of A20 haploinsufficiency.
Pediatr Rheumatol Online J. 2021 May 24;19(1):75. doi: 10.1186/s12969-021-00558-6.
Pediatr Rheumatol Online J. 2021.
PMID: 34030699
Free PMC article.
Regarding laboratory tests, patients were found to have elevated white blood cell (WBC) count, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR). ...It may present as Behcet-like syndrome and resemble various other autoimmune …
Regarding laboratory tests, patients were found to have elevated white blood cell (WBC) count, C-reactive protei …
Autoimmune hemolytic anemia, a rare disease in newborns: a case report.
Ann Med Surg (Lond). 2023 Apr 18;85(5):2212-2215. doi: 10.1097/MS9.0000000000000681. eCollection 2023 May.
Ann Med Surg (Lond). 2023.
PMID: 37229037
Free PMC article.
Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia in which autoantibodies attack the membrane antigens of red blood cells, causing cell rupture (lysis). ...Laboratory investigations were ordered, which showed hemoglobin was decreasing continuou …
Autoimmune hemolytic anemia (AIHA) is a type of hemolytic anemia in which autoantibodies attack the membrane antigens of red blood …
Alterations in B cell development, CDR-H3 repertoire and dsDNA-binding antibody production among C57BL/6 ΔD-iD mice congenic for the lupus susceptibility loci sle1, sle2 or sle3.
Autoimmunity. 2017 Feb;50(1):42-51. doi: 10.1080/08916934.2016.1272597.
Autoimmunity. 2017.
PMID: 28166678
Free PMC article.
Systemic lupus erythematosus (SLE) is an autoimmune disease that reflects a failure to block the production of self-reactive antibodies, especially those that bind double-stranded DNA (dsDNA). ...We found that the combination of the deltaD-iD allele and the sle1 loc …
Systemic lupus erythematosus (SLE) is an autoimmune disease that reflects a failure to block the production of self-reactive a …
Dissecting susceptibility from exogenous triggers: the model of alopecia areata and associated inflammatory skin diseases.
J Eur Acad Dermatol Venereol. 2015 Dec;29(12):2429-35. doi: 10.1111/jdv.13325. Epub 2015 Sep 28.
J Eur Acad Dermatol Venereol. 2015.
PMID: 26416203
BACKGROUND: Alopecia areata (AA) is a T-cell-driven autoimmune disease of the hair follicle and frequently reported to be associated with inflammatory skin diseases (ISD) such as atopic eczema (AE) or psoriasis. ...More importantly, we showed that by u …
BACKGROUND: Alopecia areata (AA) is a T-cell-driven autoimmune disease of the hair follicle and frequently reported to …
The association between the lymphocyte-monocyte ratio and disease activity in rheumatoid arthritis.
Clin Rheumatol. 2017 Dec;36(12):2689-2695. doi: 10.1007/s10067-017-3815-2. Epub 2017 Sep 14.
Clin Rheumatol. 2017.
PMID: 28913574
The lymphocyte-monocyte ratio (LMR) is a systemic inflammatory marker for prediction of disease development, progress, and survival. Recently, a genome-wide association study identified genetic variations in ITGA4 and HLA-DRB1 that affect the LMR levels and were wid …
The lymphocyte-monocyte ratio (LMR) is a systemic inflammatory marker for prediction of disease development, progress, and survival. …
NK/T cell ratios associate with interleukin-2 receptor alpha chain expression and shedding in multiple sclerosis.
J Neuroimmunol. 2021 Apr 15;353:577499. doi: 10.1016/j.jneuroim.2021.577499. Epub 2021 Jan 24.
J Neuroimmunol. 2021.
PMID: 33529846
Free article.
NK/T-cell ratios predict disease activity in relapsing remitting multiple sclerosis (RRMS). ...CD56(bright) NK-cell/IL-17A(+)CD4(+) T-cell ratios correlated negatively with plasma and PBMC-culture supernatant sIL-2Ralpha-levels [R = -0.209; p = 0.038 a …
NK/T-cell ratios predict disease activity in relapsing remitting multiple sclerosis (RRMS). ...CD56(bright) NK-cell/IL- …
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