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2003 1
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2013 5
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Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies.
Larsson SC, Burgess S. Larsson SC, et al. BMC Med. 2021 Dec 15;19(1):320. doi: 10.1186/s12916-021-02188-x. BMC Med. 2021. PMID: 34906131 Free PMC article.
RESULTS: In a meta-analysis of results from published MR studies and de novo analyses of the FinnGen consortium, genetically predicted higher BMI was associated with increased risk of type 2 diabetes mellitus, 14 circulatory disease outcomes, asthma, chronic …
RESULTS: In a meta-analysis of results from published MR studies and de novo analyses of the FinnGen consortium, genetically predi …
Attributes and predictors of long COVID.
Sudre CH, Murray B, Varsavsky T, Graham MS, Penfold RS, Bowyer RC, Pujol JC, Klaser K, Antonelli M, Canas LS, Molteni E, Modat M, Jorge Cardoso M, May A, Ganesh S, Davies R, Nguyen LH, Drew DA, Astley CM, Joshi AD, Merino J, Tsereteli N, Fall T, Gomez MF, Duncan EL, Menni C, Williams FMK, Franks PW, Chan AT, Wolf J, Ourselin S, Spector T, Steves CJ. Sudre CH, et al. Nat Med. 2021 Apr;27(4):626-631. doi: 10.1038/s41591-021-01292-y. Epub 2021 Mar 10. Nat Med. 2021. PMID: 33692530 Free PMC article.
Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known about prevalence, risk factors or whether it is possible to predict a protracted course early in the disease. ...Long COVID was ch …
Reports of long-lasting coronavirus disease 2019 (COVID-19) symptoms, the so-called 'long COVID', are rising but little is known abou …
Genomics in Personalized Nutrition: Can You "Eat for Your Genes"?
Mullins VA, Bresette W, Johnstone L, Hallmark B, Chilton FH. Mullins VA, et al. Nutrients. 2020 Oct 13;12(10):3118. doi: 10.3390/nu12103118. Nutrients. 2020. PMID: 33065985 Free PMC article. Review.
Genome-wide single nucleotide polymorphism (SNP) data are now quickly and inexpensively acquired, raising the prospect of creating personalized dietary recommendations based on an individual's genetic variability at multiple SNPs. However, relatively little is known …
Genome-wide single nucleotide polymorphism (SNP) data are now quickly and inexpensively acquired, raising the prospect of creating personali …
Health effects of milk consumption: phenome-wide Mendelian randomization study.
Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC. Yuan S, et al. BMC Med. 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. BMC Med. 2022. PMID: 36424608 Free PMC article.
An inverse association for type 2 diabetes risk (OR, 0.92, 95% CI, 0.86-0.97; p=0.003) was observed in MR analysis based on genetic data with body mass index adjustment but not in the corresponding data without body mass index adju …
An inverse association for type 2 diabetes risk (OR, 0.92, 95% CI, 0.86-0.97; p=0.003) was observed in MR analysis based on genetic d …
Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses.
Mukherjee S, Walter S, Kauwe JSK, Saykin AJ, Bennett DA, Larson EB, Crane PK, Glymour MM; Adult Changes in Thought Study Investigators; Religious Orders Study/Memory and Aging Project Investigators; Alzheimer's Disease Genetics Consortium. Mukherjee S, et al. Alzheimers Dement. 2015 Dec;11(12):1439-1451. doi: 10.1016/j.jalz.2015.05.015. Epub 2015 Jun 12. Alzheimers Dement. 2015. PMID: 26079416 Free PMC article.
Observational research shows that higher body mass index (BMI) increases Alzheimer's disease (AD) risk, but it is unclear whether this association is causal. ...We evaluated individual-level data from the AD Genetics Consortium (AD …
Observational research shows that higher body mass index (BMI) increases Alzheimer's disease (AD) …
Body Mass Index and Polygenic Risk for Alzheimer's Disease Predict Conversion to Alzheimer's Disease.
Moody JN, Valerio KE, Hasselbach AN, Prieto S, Logue MW, Hayes SM, Hayes JP; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Moody JN, et al. J Gerontol A Biol Sci Med Sci. 2021 Jul 13;76(8):1415-1422. doi: 10.1093/gerona/glab117. J Gerontol A Biol Sci Med Sci. 2021. PMID: 33880516 Free PMC article.
Body mass index (BMI) is a risk factor for Alzheimer's disease (AD) although the relationship is complex. ...Participants included 52 individuals diagnosed as having mild cognitive impairment (MCI) at baseline who converted to AD within 2 …
Body mass index (BMI) is a risk factor for Alzheimer's disease (AD) although the relationship is c …
Body Mass Index Decrease Has a Distinct Association with Alzheimer's Disease Pathophysiology in APOE ɛ4 Carriers and Non-Carriers.
Li A, Du J, Cai Y, Chen X, Sun K, Guo T; Alzheimer’s Disease Neuroimaging Initiative. Li A, et al. J Alzheimers Dis. 2023;96(2):643-655. doi: 10.3233/JAD-230446. J Alzheimers Dis. 2023. PMID: 37840490
BACKGROUND: Body mass index (BMI) changes may be related to Alzheimer's disease (AD) alterations, but it is unclear how the apolipoprotein E e4 (APOE e4) allele affects their association. ...CONCLUSIONS: This study highlights the signific …
BACKGROUND: Body mass index (BMI) changes may be related to Alzheimer's disease (AD) alterations, …
Higher Body Mass Index Is Associated with Lower Cortical Amyloid-β Burden in Cognitively Normal Individuals in Late-Life.
Thirunavu V, McCullough A, Su Y, Flores S, Dincer A, Morris JC, Cruchaga C, Benzinger TLS, Gordon BA. Thirunavu V, et al. J Alzheimers Dis. 2019;69(3):817-827. doi: 10.3233/JAD-190154. J Alzheimers Dis. 2019. PMID: 31156169 Free PMC article.
BACKGROUND: Both low and high body mass index (BMI) have been associated with an increased risk of dementia, including that caused by Alzheimer's disease (AD). ...METHODS: We analyzed cross-sectional baseline data from the Knight Alzhe …
BACKGROUND: Both low and high body mass index (BMI) have been associated with an increased risk of dementia, including …
Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers.
Kadey KR, Woodard JL, Moll AC, Nielson KA, Smith JC, Durgerian S, Rao SM. Kadey KR, et al. J Alzheimers Dis. 2021;81(1):189-199. doi: 10.3233/JAD-201360. J Alzheimers Dis. 2021. PMID: 33749649
BACKGROUND: Body mass index (BMI) has been identified as an important modifiable lifestyle risk factor for dementia, but less is known about how BMI might interact with Apolipoprotein E e4 (APOE e4) carrier status to predict conversion to mild cognitiv …
BACKGROUND: Body mass index (BMI) has been identified as an important modifiable lifestyle risk factor for dementia, bu …
Life Course Adiposity and Alzheimer's Disease: A Mendelian Randomization Study.
Li X, Tian Y, Yang YX, Ma YH, Shen XN, Chen SD, Dong Q, Tan L, Yu JT. Li X, et al. J Alzheimers Dis. 2021;82(2):503-512. doi: 10.3233/JAD-210345. J Alzheimers Dis. 2021. PMID: 34057091
BACKGROUND: Several studies showed that life course adiposity was associated with Alzheimer's disease (AD). However, the underlying causality remains unclear. ...METHODS: Instrumental variants were obtained from large genome-wide association studies (GWAS) fo …
BACKGROUND: Several studies showed that life course adiposity was associated with Alzheimer's disease (AD). However, th …
57 results