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Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways.
Huang B, Chen Z, Geng L, Wang J, Liang H, Cao Y, Chen H, Huang W, Su M, Wang H, Xu Y, Liu Y, Lu B, Xian H, Li H, Li H, Ren L, Xie J, Ye L, Wang H, Zhao J, Chen P, Zhang L, Zhao S, Zhang T, Xu B, Che D, Si W, Gu X, Zeng L, Wang Y, Li D, Zhan Y, Delfouneso D, Lew AM, Cui J, Tang WH, Zhang Y, Gong S, Bai F, Yang M, Zhang Y. Huang B, et al. Among authors: geng l. Cell. 2019 Nov 14;179(5):1160-1176.e24. doi: 10.1016/j.cell.2019.10.027. Cell. 2019. PMID: 31730855 Free article.
Excessive deubiquitination of NLRP3-R779C variant contributes to very-early-onset inflammatory bowel disease development.
Zhou L, Liu T, Huang B, Luo M, Chen Z, Zhao Z, Wang J, Leung D, Yang X, Chan KW, Liu Y, Xiong L, Chen P, Wang H, Ye L, Liang H, Masters SL, Lew AM, Gong S, Bai F, Yang J, Pui-Wah Lee P, Yang W, Zhang Y, Lau YL, Geng L, Zhang Y, Cui J. Zhou L, et al. Among authors: geng l. J Allergy Clin Immunol. 2021 Jan;147(1):267-279. doi: 10.1016/j.jaci.2020.09.003. Epub 2020 Sep 15. J Allergy Clin Immunol. 2021. PMID: 32941940 Clinical Trial.
Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency.
Hughes SA, Lin M, Weir A, Huang B, Xiong L, Chua NK, Pang J, Santavanond JP, Tixeira R, Doerflinger M, Deng Y, Yu CH, Silke N, Conos SA, Frank D, Simpson DS, Murphy JM, Lawlor KE, Pearson JS, Silke J, Pellegrini M, Herold MJ, Poon IKH, Masters SL, Li M, Tang Q, Zhang Y, Rashidi M, Geng L, Vince JE. Hughes SA, et al. Among authors: geng l. EMBO J. 2023 Mar 1;42(5):e110468. doi: 10.15252/embj.2021110468. Epub 2023 Jan 17. EMBO J. 2023. PMID: 36647737 Free PMC article.
The transcription factor ELF4 alleviates inflammatory bowel disease by activating IL1RN transcription, suppressing inflammatory TH17 cell activity, and inducing macrophage M2 polarization.
Cao M, Chen P, Peng B, Cheng Y, Xie J, Hou Z, Chen H, Ye L, Li H, Wang H, Ren L, Xiong L, Geng L, Gong S. Cao M, et al. Among authors: geng l. Front Immunol. 2023 Nov 6;14:1270411. doi: 10.3389/fimmu.2023.1270411. eCollection 2023. Front Immunol. 2023. PMID: 38022496 Free PMC article.
1,825 results