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Genome maintenance mechanisms for preventing cancer.
Hoeijmakers JH. Hoeijmakers JH. Nature. 2001 May 17;411(6835):366-74. doi: 10.1038/35077232. Nature. 2001. PMID: 11357144 Review.
The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. ...At the same time, it has become apparent that inherited or acquired deficienc …
The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome …
BRCA1 gene sequence variation in centenarians.
Vijg J, Perls T, Franceschi C, van Orsouw NJ. Vijg J, et al. Ann N Y Acad Sci. 2001 Apr;928:85-96. doi: 10.1111/j.1749-6632.2001.tb05639.x. Ann N Y Acad Sci. 2001. PMID: 11795532 Review.
Such a genetic epidemiological approach could lead to new insights with respect to the basic mechanisms of aging and longevity as well as the identification of new targets to prevent or retard some of the late-age adverse effects. Using our recently developed two-di …
Such a genetic epidemiological approach could lead to new insights with respect to the basic mechanisms of aging and longevity as wel …
Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines.
Tsuiki H, Nitta M, Tada M, Inagaki M, Ushio Y, Saya H. Tsuiki H, et al. Oncogene. 2001 Jan 25;20(4):420-9. doi: 10.1038/sj.onc.1204126. Oncogene. 2001. PMID: 11313973
Checkpoint mechanism plays a crucial role in ensuring genomic integrity during cell cycle. Loss of checkpoint function is known to induce genomic instability and to alter ploidy of dividing cells. ...Interestingly, inhibitors specific for cdc2 kinase preve …
Checkpoint mechanism plays a crucial role in ensuring genomic integrity during cell cycle. Loss of checkpoint function is know …