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Genome-Wide Association Study of CKD Progression.
Robinson-Cohen C, Triozzi JL, Rowan B, He J, Chen HC, Zheng NS, Wei WQ, Wilson OD, Hellwege JN, Tsao PS, Gaziano JM, Bick A, Matheny ME, Chung CP, Lipworth L, Siew ED, Ikizler TA, Tao R, Hung AM. Robinson-Cohen C, et al. J Am Soc Nephrol. 2023 Sep 1;34(9):1547-1559. doi: 10.1681/ASN.0000000000000170. Epub 2023 Jun 1. J Am Soc Nephrol. 2023. PMID: 37261792
The authors conducted a meta-analysis of genome-wide association studies of eGFR decline among 116,870 participants with CKD, focusing on longitudinal data. ...CONCLUSIONS: Three loci were significantly associated with longitudinal eGFR change at ge
The authors conducted a meta-analysis of genome-wide association studies of eGFR decline among 116,870 participants wit …
Risk Factors for CKD Progression: Overview of Findings from the CRIC Study.
Hannan M, Ansari S, Meza N, Anderson AH, Srivastava A, Waikar S, Charleston J, Weir MR, Taliercio J, Horwitz E, Saunders MR, Wolfrum K, Feldman HI, Lash JP, Ricardo AC; CRIC Study Investigators; Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Hannan M, et al. Clin J Am Soc Nephrol. 2021 Apr 7;16(4):648-659. doi: 10.2215/CJN.07830520. Epub 2020 Nov 11. Clin J Am Soc Nephrol. 2021. PMID: 33177074 Free PMC article.
Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD progression. This review summarizes findings from longitudinal studies evaluating risk factors associated with CKD progress
Over the past 10 years, the CRIC Study has made significant contributions to the understanding of factors associated with CKD
Kidney damage causally affects the brain cortical structure: A Mendelian randomization study.
Chen X, Kong J, Pan J, Huang K, Zhou W, Diao X, Cai J, Zheng J, Yang X, Xie W, Yu H, Li J, Pei L, Dong W, Qin H, Huang J, Lin T. Chen X, et al. EBioMedicine. 2021 Oct;72:103592. doi: 10.1016/j.ebiom.2021.103592. Epub 2021 Oct 4. EBioMedicine. 2021. PMID: 34619639 Free PMC article. Clinical Trial.
BACKGROUND: Alterations in the brain cortical structures of patients with chronic kidney disease (CKD) have been reported; however, the cause has not been determined yet. Herein, we used Mendelian randomization (MR) to reveal the causal effect of kidney damage on br …
BACKGROUND: Alterations in the brain cortical structures of patients with chronic kidney disease (CKD) have been reported; how …
Coffee Consumption and Kidney Function: A Mendelian Randomization Study.
Kennedy OJ, Pirastu N, Poole R, Fallowfield JA, Hayes PC, Grzeszkowiak EJ, Taal MW, Wilson JF, Parkes J, Roderick PJ. Kennedy OJ, et al. Am J Kidney Dis. 2020 May;75(5):753-761. doi: 10.1053/j.ajkd.2019.08.025. Epub 2019 Dec 11. Am J Kidney Dis. 2020. PMID: 31837886
RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited strategies for prevention and treatment. ...This work aimed to determine the impact of coffee consumption on kidney function. STUDY D …
RATIONALE & OBJECTIVE: Chronic kidney disease (CKD) is a leading cause of morbidity and mortality worldwide, with limited …
Causal effects of gut microbiota on the risk of chronic kidney disease: a Mendelian randomization study.
Luo M, Cai J, Luo S, Hong X, Xu L, Lin H, Chen X, Fu W. Luo M, et al. Front Cell Infect Microbiol. 2023 Mar 31;13:1142140. doi: 10.3389/fcimb.2023.1142140. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37065213 Free PMC article.
BACKGROUND: Previous studies have reported that gut microbiota is associated with an increased risk of chronic kidney disease (CKD) progression. However, whether gut microbiota has a causal effect on the development of CKD has not been revealed. ...CON …
BACKGROUND: Previous studies have reported that gut microbiota is associated with an increased risk of chronic kidney disease (CKD
Causal Effects of Specific Gut Microbiota on Chronic Kidney Diseases and Renal Function-A Two-Sample Mendelian Randomization Study.
Li N, Wang Y, Wei P, Min Y, Yu M, Zhou G, Yuan G, Sun J, Dai H, Zhou E, He W, Sheng M, Gao K, Zheng M, Sun W, Zhou D, Zhang L. Li N, et al. Nutrients. 2023 Jan 11;15(2):360. doi: 10.3390/nu15020360. Nutrients. 2023. PMID: 36678231 Free PMC article.
BACKGROUND: Targeting the gut microbiota may become a new therapeutic to prevent and delay the progression of chronic kidney disease (CKD). Nonetheless, the causal relationship between specific intestinal flora and CKD is still unclear. MATERIALS AND M …
BACKGROUND: Targeting the gut microbiota may become a new therapeutic to prevent and delay the progression of chronic kidney disea
Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.
Parsa A, Kanetsky PA, Xiao R, Gupta J, Mitra N, Limou S, Xie D, Xu H, Anderson AH, Ojo A, Kusek JW, Lora CM, Hamm LL, He J, Sandholm N, Jeff J, Raj DE, Böger CA, Bottinger E, Salimi S, Parekh RS, Adler SG, Langefeld CD, Bowden DW; FIND Consortium; Groop PH, Forsblom C, Freedman BI, Lipkowitz M, Fox CS, Winkler CA, Feldman HI; and the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Parsa A, et al. J Am Soc Nephrol. 2017 Mar;28(3):923-934. doi: 10.1681/ASN.2015101152. Epub 2016 Oct 11. J Am Soc Nephrol. 2017. PMID: 27729571 Free PMC article.
The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chr …
The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genet …
The Effect of DNA Methylation in the Development and Progression of Chronic Kidney Disease in the General Population: An Epigenome-Wide Association Study Using the Korean Genome and Epidemiology Study Database.
Kim JE, Jo MJ, Cho E, Ahn SY, Kwon YJ, Gim JA, Ko GJ. Kim JE, et al. Genes (Basel). 2023 Jul 21;14(7):1489. doi: 10.3390/genes14071489. Genes (Basel). 2023. PMID: 37510393 Free PMC article.
BACKGROUND: Although knowledge of the genetic factors influencing kidney disease is increasing, epigenetic profiles, which are associated with chronic kidney disease (CKD), have not been fully elucidated. We sought to identify the DNA methylation status of Cp …
BACKGROUND: Although knowledge of the genetic factors influencing kidney disease is increasing, epigenetic profiles, which are associ …
Genome-wide association studies of chronic kidney disease: what have we learned?
O'Seaghdha CM, Fox CS. O'Seaghdha CM, et al. Nat Rev Nephrol. 2011 Dec 6;8(2):89-99. doi: 10.1038/nrneph.2011.189. Nat Rev Nephrol. 2011. PMID: 22143329 Free PMC article. Review.
The majority of associations reported from genome-wide association studies identify genomic regions of interest and further work will be required to identify the causal variants responsible for a specific phenotype. ...Follow-up studies stimulated by findings …
The majority of associations reported from genome-wide association studies identify genomic regions of interest and fur …
Causal effects of systemic inflammatory regulators on chronic kidney diseases and renal function: a bidirectional Mendelian randomization study.
Li H, Li M, Liu C, He P, Dong A, Dong S, Zhang M. Li H, et al. Front Immunol. 2023 Aug 30;14:1229636. doi: 10.3389/fimmu.2023.1229636. eCollection 2023. Front Immunol. 2023. PMID: 37711613 Free PMC article.
BACKGROUND: While targeted systemic inflammatory modulators show promise in preventing chronic kidney disease (CKD) progression, the causal link between specific inflammatory factors and CKD remains uncertain. METHODS: Using a genome-wide
BACKGROUND: While targeted systemic inflammatory modulators show promise in preventing chronic kidney disease (CKD) progres
62 results