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Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.
Salem RM, Todd JN, Sandholm N, Cole JB, Chen WM, Andrews D, Pezzolesi MG, McKeigue PM, Hiraki LT, Qiu C, Nair V, Di Liao C, Cao JJ, Valo E, Onengut-Gumuscu S, Smiles AM, McGurnaghan SJ, Haukka JK, Harjutsalo V, Brennan EP, van Zuydam N, Ahlqvist E, Doyle R, Ahluwalia TS, Lajer M, Hughes MF, Park J, Skupien J, Spiliopoulou A, Liu A, Menon R, Boustany-Kari CM, Kang HM, Nelson RG, Klein R, Klein BE, Lee KE, Gao X, Mauer M, Maestroni S, Caramori ML, de Boer IH, Miller RG, Guo J, Boright AP, Tregouet D, Gyorgy B, Snell-Bergeon JK, Maahs DM, Bull SB, Canty AJ, Palmer CNA, Stechemesser L, Paulweber B, Weitgasser R, Sokolovska J, Rovīte V, Pīrāgs V, Prakapiene E, Radzeviciene L, Verkauskiene R, Panduru NM, Groop LC, McCarthy MI, Gu HF, Möllsten A, Falhammar H, Brismar K, Martin F, Rossing P, Costacou T, Zerbini G, Marre M, Hadjadj S, McKnight AJ, Forsblom C, McKay G, Godson C, Maxwell AP, Kretzler M, Susztak K, Colhoun HM, Krolewski A, Paterson AD, Groop PH, Rich SS, Hirschhorn JN, Florez JC; SUMMIT Consortium, DCCT/EDIC Research Group, GENIE Consortium. Salem RM, et al. J Am Soc Nephrol. 2019 Oct;30(10):2000-2016. doi: 10.1681/ASN.2019030218. Epub 2019 Sep 19. J Am Soc Nephrol. 2019. PMID: 31537649 Free PMC article.
METHODS: To identify genetic variants predisposing to diabetic kidney disease, we performed genome-wide association study (GWAS) analyses. ...We identified 16 genome-wide significant risk loci. The varia …
METHODS: To identify genetic variants predisposing to diabetic kidney disease, we performed genome-wide
Genome-wide association studies of albuminuria: towards genetic stratification in diabetes?
Pattaro C. Pattaro C. J Nephrol. 2018 Aug;31(4):475-487. doi: 10.1007/s40620-017-0437-3. Epub 2017 Sep 16. J Nephrol. 2018. PMID: 28918587 Review.
Genome-wide association studies (GWAS) have been very successful in unraveling the polygenic structure of several complex diseases and traits. ...So far, very few loci associated with albuminuria have been validated by means of
Genome-wide association studies (GWAS) have been very successful in unraveling the polygenic structure of severa
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.
Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y, Mijatovic V, Ko YA, Taliun D, Luciani A, Chen MH, Yang Q, Foster MC, Olden M, Hiraki LT, Tayo BO, Fuchsberger C, Dieffenbach AK, Shuldiner AR, Smith AV, Zappa AM, Lupo A, Kollerits B, Ponte B, Stengel B, Krämer BK, Paulweber B, Mitchell BD, Hayward C, Helmer C, Meisinger C, Gieger C, Shaffer CM, Müller C, Langenberg C, Ackermann D, Siscovick D; DCCT/EDIC; Boerwinkle E, Kronenberg F, Ehret GB, Homuth G, Waeber G, Navis G, Gambaro G, Malerba G, Eiriksdottir G, Li G, Wichmann HE, Grallert H, Wallaschofski H, Völzke H, Brenner H, Kramer H, Mateo Leach I, Rudan I, Hillege HL, Beckmann JS, Lambert JC, Luan J, Zhao JH, Chalmers J, Coresh J, Denny JC, Butterbach K, Launer LJ, Ferrucci L, Kedenko L, Haun M, Metzger M, Woodward M, Hoffman MJ, Nauck M, Waldenberger M, Pruijm M, Bochud M, Rheinberger M, Verweij N, Wareham NJ, Endlich N, Soranzo N, Polasek O, van der Harst P, Pramstaller PP, Vollenweider P, Wild PS, Gansevoort RT, Rettig R, Biffar R, Carroll RJ, Katz R, Loos RJ, Hwang SJ, Coassin S, Bergmann S, Rosas SE, Stracke S, Harris TB, Corre T, Zeller T, Illig T, Aspelund T, Tanaka T, Lendeckel U, Völker U, Gudnason V, Cho… See abstract for full author list ➔ Teumer A, et al. Diabetes. 2016 Mar;65(3):803-17. doi: 10.2337/db15-1313. Epub 2015 Dec 2. Diabetes. 2016. PMID: 26631737 Free PMC article.
To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide association studies and independent replication in up to 5,825 individuals of European ancestry with diabetes and up …
To gain insight into the pathophysiological mechanisms underlying albuminuria, we conducted meta-analyses of genome-wide
Genome-wide studies to identify risk factors for kidney disease with a focus on patients with diabetes.
Regele F, Jelencsics K, Shiffman D, Paré G, McQueen MJ, Mann JF, Oberbauer R. Regele F, et al. Nephrol Dial Transplant. 2015 Aug;30 Suppl 4:iv26-34. doi: 10.1093/ndt/gfv087. Nephrol Dial Transplant. 2015. PMID: 26209735 Review.
In addition to known demographic, biochemical and lifestyle risk factors, genetics is also contributing to CKD risk. In recent years, genome-wide association studies (GWAS) have provided a hypothesis-free approach to identify common genetic
In addition to known demographic, biochemical and lifestyle risk factors, genetics is also contributing to CKD risk. In recent years, gen
Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
Teumer A, Li Y, Ghasemi S, Prins BP, Wuttke M, Hermle T, Giri A, Sieber KB, Qiu C, Kirsten H, Tin A, Chu AY, Bansal N, Feitosa MF, Wang L, Chai JF, Cocca M, Fuchsberger C, Gorski M, Hoppmann A, Horn K, Li M, Marten J, Noce D, Nutile T, Sedaghat S, Sveinbjornsson G, Tayo BO, van der Most PJ, Xu Y, Yu Z, Gerstner L, Ärnlöv J, Bakker SJL, Baptista D, Biggs ML, Boerwinkle E, Brenner H, Burkhardt R, Carroll RJ, Chee ML, Chee ML, Chen M, Cheng CY, Cook JP, Coresh J, Corre T, Danesh J, de Borst MH, De Grandi A, de Mutsert R, de Vries APJ, Degenhardt F, Dittrich K, Divers J, Eckardt KU, Ehret G, Endlich K, Felix JF, Franco OH, Franke A, Freedman BI, Freitag-Wolf S, Gansevoort RT, Giedraitis V, Gögele M, Grundner-Culemann F, Gudbjartsson DF, Gudnason V, Hamet P, Harris TB, Hicks AA, Holm H, Foo VHX, Hwang SJ, Ikram MA, Ingelsson E, Jaddoe VWV, Jakobsdottir J, Josyula NS, Jung B, Kähönen M, Khor CC, Kiess W, Koenig W, Körner A, Kovacs P, Kramer H, Krämer BK, Kronenberg F, Lange LA, Langefeld CD, Lee JJ, Lehtimäki T, Lieb W, Lim SC, Lind L, Lindgren CM, Liu J, Loeffler M, Lyytikäinen LP, Mahajan A, Maranville JC, Mascalzoni D, McMullen B, Meisinger C, Meitinger T, Miliku K, Mook-Kanamori DO,… See abstract for full author list ➔ Teumer A, et al. Nat Commun. 2019 Sep 11;10(1):4130. doi: 10.1038/s41467-019-11576-0. Nat Commun. 2019. PMID: 31511532 Free PMC article.
Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association studies of UACR, including ancestry- and diabetes-specific analyses, and identify 68 UACR-associated loci. …
Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses of genome-wide association
Chronic kidney disease: novel insights from genome-wide association studies.
Böger CA, Heid IM. Böger CA, et al. Kidney Blood Press Res. 2011;34(4):225-34. doi: 10.1159/000326901. Epub 2011 Jun 21. Kidney Blood Press Res. 2011. PMID: 21691125 Free article. Review.
Apart from the risk conferred by traditional cardiovascular risk factors, there is a strong genetic component. The method of a genome-wide association study (GWAS) is a powerful hypothesis-free approach to unravel this component by associatio
Apart from the risk conferred by traditional cardiovascular risk factors, there is a strong genetic component. The method of a gen
Insights into the genetic architecture of diabetic nephropathy.
Palmer ND, Freedman BI. Palmer ND, et al. Curr Diab Rep. 2012 Aug;12(4):423-31. doi: 10.1007/s11892-012-0279-2. Curr Diab Rep. 2012. PMID: 22573336 Free PMC article. Review.
Progress in identifying the underlying genetic architecture has been arduous with the realization that a single locus of large effect does not exist, unlike in predisposition to non-diabetic nephropathy in individuals with African ancestry. ...These results h …
Progress in identifying the underlying genetic architecture has been arduous with the realization that a single locus of large …
Association of prediabetes-associated single nucleotide polymorphisms with microalbuminuria.
Choi JW, Moon S, Jang EJ, Lee CH, Park JS. Choi JW, et al. PLoS One. 2017 Feb 3;12(2):e0171367. doi: 10.1371/journal.pone.0171367. eCollection 2017. PLoS One. 2017. PMID: 28158221 Free PMC article.
Increased glycemic exposure, even below the diagnostic criteria for diabetes mellitus, is crucial in the pathogenesis of diabetic microvascular complications represented by microalbuminuria. ...Our results suggest that prediabetes and the associated SN …
Increased glycemic exposure, even below the diagnostic criteria for diabetes mellitus, is crucial in the pathogenesis of di
A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin-creatinine ratio.
Casanova F, Tyrrell J, Beaumont RN, Ji Y, Jones SE, Hattersley AT, Weedon MN, Murray A, Shore AC, Frayling TM, Wood AR. Casanova F, et al. Hum Mol Genet. 2019 Dec 15;28(24):4197-4207. doi: 10.1093/hmg/ddz243. Hum Mol Genet. 2019. PMID: 31630189 Free PMC article.
We performed a genome-wide association study of ACR using 437 027 individuals from the UK Biobank in the discovery phase, 54 527 more than previous studies, and followed up our findings in independent studies. We identified 62 inde …
We performed a genome-wide association study of ACR using 437 027 individuals from the UK Biobank in the discove …
The association of genetic variants of type 2 diabetes with kidney function.
Franceschini N, Shara NM, Wang H, Voruganti VS, Laston S, Haack K, Lee ET, Best LG, Maccluer JW, Cochran BJ, Dyer TD, Howard BV, Cole SA, North KE, Umans JG. Franceschini N, et al. Kidney Int. 2012 Jul;82(2):220-5. doi: 10.1038/ki.2012.107. Epub 2012 Apr 18. Kidney Int. 2012. PMID: 22513821 Free PMC article.
Genome-wide association studies identified several loci associated with diabetes but their impact on susceptibility to diabetic complications is unknown. We studied the association of 18 type 2 diabetes
Genome-wide association studies identified several loci associated with diabetes but
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