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Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.
Renthal W, Kumar A, Xiao G, Wilkinson M, Covington HE 3rd, Maze I, Sikder D, Robison AJ, LaPlant Q, Dietz DM, Russo SJ, Vialou V, Chakravarty S, Kodadek TJ, Stack A, Kabbaj M, Nestler EJ. Renthal W, et al. Neuron. 2009 May 14;62(3):335-48. doi: 10.1016/j.neuron.2009.03.026. Neuron. 2009. PMID: 19447090 Free PMC article.
Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide chromatin changes in the mouse nucleus accumbens, a crucial brain reward region, after repeated cocaine administration. Our …
Here, we used chromatin immunoprecipitation coupled with promoter microarray analysis to characterize genome-wide …
SIRT1-FOXO3a regulate cocaine actions in the nucleus accumbens.
Ferguson D, Shao N, Heller E, Feng J, Neve R, Kim HD, Call T, Magazu S, Shen L, Nestler EJ. Ferguson D, et al. J Neurosci. 2015 Feb 18;35(7):3100-11. doi: 10.1523/JNEUROSCI.4012-14.2015. J Neurosci. 2015. PMID: 25698746 Free PMC article.
To determine the mechanisms by which SIRT1 mediates cocaine-induced plasticity in NAc, we used chromatin immunoprecipitation followed by massively parallel sequencing (ChIP-seq), 1 d after 7 daily cocaine (20 mg/kg) or saline injections, to map SIRT1 binding …
To determine the mechanisms by which SIRT1 mediates cocaine-induced plasticity in NAc, we used chromatin immunoprecipitation f …