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Genome-wide association analysis of common genetic variants of resistant hypertension.
El Rouby N, McDonough CW, Gong Y, McClure LA, Mitchell BD, Horenstein RB, Talbert RL, Crawford DC; eMERGE network, Gitzendanner MA, Takahashi A, Tanaka T, Kubo M, Pepine CJ, Cooper-DeHoff RM, Benavente OR, Shuldiner AR, Johnson JA. El Rouby N, et al. Pharmacogenomics J. 2019 Jun;19(3):295-304. doi: 10.1038/s41397-018-0049-x. Epub 2018 Sep 20. Pharmacogenomics J. 2019. PMID: 30237584 Free PMC article. Clinical Trial.
We conducted a genome-wide association analysis in 1194 White and Hispanic participants with hypertension and coronary artery disease from the INternational VErapamil-SR Trandolapril STudy-GENEtic Substudy (INVEST-GENES). ...A g
We conducted a genome-wide association analysis in 1194 White and Hispanic participants with hypertension
Impact of Genetic Loci Identified in Genome-Wide Association Studies on Diabetic Retinopathy in Chinese Patients With Type 2 Diabetes.
Cheung CY, Hui EY, Lee CH, Kwok KH, Gangwani RA, Li KK, Chan JC, Woo YC, Chow WS, Yuen MM, Wong RL, Fong CH, Xu A, Wong DS, Sham PC, Lam KS. Cheung CY, et al. Invest Ophthalmol Vis Sci. 2016 Oct 1;57(13):5518-5524. doi: 10.1167/iovs.16-20094. Invest Ophthalmol Vis Sci. 2016. PMID: 27768789
PURPOSE: Diabetic retinopathy (DR) is a common microvascular complication of type 2 diabetes (T2DM). Genome-wide association studies (GWAS) had identified novel DR-susceptibility genetic variants in various populations. ...The findings on …
PURPOSE: Diabetic retinopathy (DR) is a common microvascular complication of type 2 diabetes (T2DM). Genome-wide ass
An update on the pharmacogenetics of treating hypertension.
Fontana V, Luizon MR, Sandrim VC. Fontana V, et al. J Hum Hypertens. 2015 May;29(5):283-91. doi: 10.1038/jhh.2014.76. Epub 2014 Aug 28. J Hum Hypertens. 2015. PMID: 25355012 Free article. Review.
Candidate gene and genome-wide approaches have identified common genetic variants associated with response to antihypertensive drugs. ...Despite some genetic variants with evidence of association with the variable response r …
Candidate gene and genome-wide approaches have identified common genetic variants associated with respons …
Risk of pre-eclampsia in patients with a maternal genetic predisposition to common medical conditions: a case-control study.
Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, Wilson ML, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gray KJ, et al. BJOG. 2020 Aug 2. doi: 10.1111/1471-0528.16441. Online ahead of print. BJOG. 2020. PMID: 32741103
METHODS: Significant single-nucleotide polymorphisms (SNPs) from 21 traits in seven disease categories (cardiovascular, inflammatory/autoimmune, insulin resistance, liver, obesity, renal and thrombophilia) with published genome-wide association studies …
METHODS: Significant single-nucleotide polymorphisms (SNPs) from 21 traits in seven disease categories (cardiovascular, inflammatory/autoimm …
Cathepsin A-related arteriopathy with strokes and leukoencephalopathy (CARASAL).
Bugiani M, Kevelam SH, Bakels HS, Waisfisz Q, Ceuterick-de Groote C, Niessen HW, Abbink TE, Lesnik Oberstein SA, van der Knaap MS. Bugiani M, et al. Neurology. 2016 Oct 25;87(17):1777-1786. doi: 10.1212/WNL.0000000000003251. Epub 2016 Sep 24. Neurology. 2016. PMID: 27664989
The clinical picture was dominated by ischemic and hemorrhagic strokes, slow and late cognitive deterioration, and therapy-resistant hypertension. With whole-exome sequencing, we identified one variant shared by both families and segregating with the d …
The clinical picture was dominated by ischemic and hemorrhagic strokes, slow and late cognitive deterioration, and therapy-resista
Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes.
Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC, Fox CS, Walker M, Borecki IB, Knowles JW, Yerges-Armstrong L, Ohlsson C, Perry JR, Chambers JC, Kooner JS, Franceschini N, Langenberg C, Hivert MF, Dastani Z, Richards JB, Semple RK, Frayling TM. Yaghootkar H, et al. Diabetes. 2014 Dec;63(12):4369-77. doi: 10.2337/db14-0318. Epub 2014 Jul 21. Diabetes. 2014. PMID: 25048195 Free PMC article.
We selected 19 common genetic variants associated with fasting insulin-based measures of IR. We used hierarchical clustering and results from genome-wide association studies of eight nondisease outcomes of monogenic IR to group these v
We selected 19 common genetic variants associated with fasting insulin-based measures of IR. We used hierarchical clust …
Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses.
Zhang K, Rao F, Miramontes-Gonzalez JP, Hightower CM, Vaught B, Chen Y, Greenwood TA, Schork AJ, Wang L, Mahata M, Stridsberg M, Khandrika S, Biswas N, Fung MM, Waalen J, Middelberg RP, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Baker DG, Schork NJ, Nievergelt CM, O'Connor DT. Zhang K, et al. J Am Coll Cardiol. 2012 Oct 23;60(17):1678-89. doi: 10.1016/j.jacc.2012.06.042. Epub 2012 Sep 26. J Am Coll Cardiol. 2012. PMID: 23021333 Free PMC article.
OBJECTIVES: This study sought to understand whether genetic variation at the Neuropeptide Y (NPY) locus governs secretion and stress responses in vivo as well as NPY gene expression in sympathochromaffin cells. ...CONCLUSIONS: We conclude that common genet
OBJECTIVES: This study sought to understand whether genetic variation at the Neuropeptide Y (NPY) locus governs secretion and …
Genomic structure of nucleotide diversity among Lyon rat models of metabolic syndrome.
Ma MC, Atanur SS, Aitman TJ, Kwitek AE. Ma MC, et al. BMC Genomics. 2014 Mar 14;15(1):197. doi: 10.1186/1471-2164-15-197. BMC Genomics. 2014. PMID: 24628878 Free PMC article.
BACKGROUND: The metabolic syndrome (MetS), a complex disorder involving hypertension, obesity, dyslipidemia and insulin resistance, is a major risk factor for heart disease, stroke, and diabetes. ...CONCLUSIONS: Whole genome sequence analysis between t …
BACKGROUND: The metabolic syndrome (MetS), a complex disorder involving hypertension, obesity, dyslipidemia and insulin resistance
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