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Genome-wide association analysis of common genetic variants of resistant hypertension.
El Rouby N, McDonough CW, Gong Y, McClure LA, Mitchell BD, Horenstein RB, Talbert RL, Crawford DC; eMERGE network; Gitzendanner MA, Takahashi A, Tanaka T, Kubo M, Pepine CJ, Cooper-DeHoff RM, Benavente OR, Shuldiner AR, Johnson JA. El Rouby N, et al. Pharmacogenomics J. 2019 Jun;19(3):295-304. doi: 10.1038/s41397-018-0049-x. Epub 2018 Sep 20. Pharmacogenomics J. 2019. PMID: 30237584 Free PMC article. Clinical Trial.
We conducted a genome-wide association analysis in 1194 White and Hispanic participants with hypertension and coronary artery disease from the INternational VErapamil-SR Trandolapril STudy-GENEtic Substudy (INVEST-GENES). ...A genetic
We conducted a genome-wide association analysis in 1194 White and Hispanic participants with hypertension and co …
Cathepsin A-related arteriopathy with strokes and leukoencephalopathy (CARASAL).
Bugiani M, Kevelam SH, Bakels HS, Waisfisz Q, Ceuterick-de Groote C, Niessen HW, Abbink TE, Lesnik Oberstein SA, van der Knaap MS. Bugiani M, et al. Neurology. 2016 Oct 25;87(17):1777-1786. doi: 10.1212/WNL.0000000000003251. Epub 2016 Sep 24. Neurology. 2016. PMID: 27664989
The clinical picture was dominated by ischemic and hemorrhagic strokes, slow and late cognitive deterioration, and therapy-resistant hypertension. With whole-exome sequencing, we identified one variant shared by both families and segregating with the disease: …
The clinical picture was dominated by ischemic and hemorrhagic strokes, slow and late cognitive deterioration, and therapy-resistant