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Genome-wide association studies in pharmacogenomics: successes and lessons.
Motsinger-Reif AA, Jorgenson E, Relling MV, Kroetz DL, Weinshilboum R, Cox NJ, Roden DM. Motsinger-Reif AA, et al. Pharmacogenet Genomics. 2013 Aug;23(8):383-94. doi: 10.1097/FPC.0b013e32833d7b45. Pharmacogenet Genomics. 2013. PMID: 20639796 Free PMC article. Review.
OBJECTIVE: As genotyping technology has progressed, genome-wide association studies (GWAS) have matured into efficient and effective tools for mapping genes underlying human phenotypes. ...We further examine the features of successful pharmac
OBJECTIVE: As genotyping technology has progressed, genome-wide association studies (GWAS) have matured into eff …
Lessons Learned From Past Gene-Environment Interaction Successes.
Ritz BR, Chatterjee N, Garcia-Closas M, Gauderman WJ, Pierce BL, Kraft P, Tanner CM, Mechanic LE, McAllister K. Ritz BR, et al. Am J Epidemiol. 2017 Oct 1;186(7):778-786. doi: 10.1093/aje/kwx230. Am J Epidemiol. 2017. PMID: 28978190 Free PMC article. Review.
Some studies illustrated the success of studying exposure metabolism for which candidate genes can be identified. Moreover, some GE successes depended on the availability of high-quality exposure assessment and longitudinal measures, study populations …
Some studies illustrated the success of studying exposure metabolism for which candidate genes can be identified. Moreover, so …
Lymphoblastoid cell lines models of drug response: successes and lessons from this pharmacogenomic model.
Jack J, Rotroff D, Motsinger-Reif A. Jack J, et al. Curr Mol Med. 2014;14(7):833-40. doi: 10.2174/1566524014666140811113946. Curr Mol Med. 2014. PMID: 25109794 Free PMC article.
Here we review the advantages, limitations, and opportunities for using lymphoblastoid cell lines (LCL) as a model system for human pharmacogenomic studies. There are a wide range of publicly available resources with genome-wide data available f …
Here we review the advantages, limitations, and opportunities for using lymphoblastoid cell lines (LCL) as a model system for human pharm