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Year Number of Results
2012 2
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30 results

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Page 1
High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.
Plotnikov D, Huang Y, Khawaja AP, Foster PJ, Zhu Z, Guggenheim JA, He M. Plotnikov D, et al. Invest Ophthalmol Vis Sci. 2022 Jun 1;63(6):29. doi: 10.1167/iovs.63.6.29. Invest Ophthalmol Vis Sci. 2022. PMID: 35762941 Free PMC article.
PURPOSE: To test for causality with regard to the association between blood pressure (BP) and intraocular pressure (IOP) and glaucoma. METHODS: Single nucleotide polymorphisms (SNPs) associated with BP were identified in a genome-wide …
PURPOSE: To test for causality with regard to the association between blood pressure (BP) and intraocular pressure …
Genome-wide association study and meta-analysis of intraocular pressure.
Ozel AB, Moroi SE, Reed DM, Nika M, Schmidt CM, Akbari S, Scott K, Rozsa F, Pawar H, Musch DC, Lichter PR, Gaasterland D, Branham K, Gilbert J, Garnai SJ, Chen W, Othman M, Heckenlively J, Swaroop A, Abecasis G, Friedman DS, Zack D, Ashley-Koch A, Ulmer M, Kang JH; NEIGHBOR Consortium; Liu Y, Yaspan BL, Haines J, Allingham RR, Hauser MA, Pasquale L, Wiggs J, Richards JE, Li JZ. Ozel AB, et al. Hum Genet. 2014 Jan;133(1):41-57. doi: 10.1007/s00439-013-1349-5. Epub 2013 Sep 4. Hum Genet. 2014. PMID: 24002674 Free PMC article.
Recent genome-wide association studies (GWAS) reported associations with IOP at TMCO1 and GAS7, and with primary open-angle glaucoma (POAG) at CDKN2B-AS1, CAV1/CAV2, and SIX1/SIX6. ...While no signal achieved genome-wide significance in individu …
Recent genome-wide association studies (GWAS) reported associations with IOP at TMCO1 and GAS7, and with primary open-a …
Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population.
Huang L, Chen Y, Lin Y, Tam POS, Cheng Y, Shi Y, Gong B, Lu F, Yang J, Wang H, Yin Y, Cao Y, Jiang D, Zhong L, Xue B, Wang J, Hao F, Lee DY, Pang CP, Sun X, Yang Z. Huang L, et al. Sci China Life Sci. 2019 Feb;62(2):153-164. doi: 10.1007/s11427-018-9430-2. Epub 2018 Dec 24. Sci China Life Sci. 2019. PMID: 30591961
We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<910(-7), and we formall …
We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the g …
Genome-Wide Association Study Identifies Two Common Loci Associated with Pigment Dispersion Syndrome/Pigmentary Glaucoma and Implicates Myopia in its Development.
Simcoe MJ, Shah A, Fan B, Choquet H, Weisschuh N, Waseem NH, Jiang C, Melles RB, Ritch R, Mahroo OA, Wissinger B, Jorgenson E, Wiggs JL, Garway-Heath DF, Hysi PG, Hammond CJ. Simcoe MJ, et al. Ophthalmology. 2022 Jun;129(6):626-636. doi: 10.1016/j.ophtha.2022.01.005. Epub 2022 Jan 11. Ophthalmology. 2022. PMID: 35031440 Free article.
PURPOSE: To identify genetic variants associated with pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) in unrelated patients and to further understand the genetic and potentially causal relationships between PDS and associated risk factors. DESIGN: A 2-stage geno …
PURPOSE: To identify genetic variants associated with pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) in unrelated patients a …
Genome-wide association analysis of 95 549 individuals identifies novel loci and genes influencing optic disc morphology.
Han X, Qassim A, An J, Marshall H, Zhou T, Ong JS, Hassall MM, Hysi PG, Foster PJ, Khaw PT, Mackey DA, Gharahkhani P, Khawaja AP, Hewitt AW, Craig JE, MacGregor S. Han X, et al. Hum Mol Genet. 2019 Nov 1;28(21):3680-3690. doi: 10.1093/hmg/ddz193. Hum Mol Genet. 2019. PMID: 31809533
We measured the vertical optic disc diameter (DD) of the UK Biobank (UKBB) cohort (N = 67 040) and performed the largest genome-wide association study (GWAS) of DD to date. We identified 81 loci (66 novel) for vertical DD. ...We identified another 26 n …
We measured the vertical optic disc diameter (DD) of the UK Biobank (UKBB) cohort (N = 67 040) and performed the largest genome-wi …
Cannabis use and the risk of primary open-angle glaucoma: a Mendelian randomization study.
Katsimpris A, Baumeister SE, Baurecht H, Tatham AJ, Nolde M. Katsimpris A, et al. Sci Rep. 2023 Nov 10;13(1):19605. doi: 10.1038/s41598-023-45872-z. Sci Rep. 2023. PMID: 37949880 Free PMC article.
Several observational studies have investigated the association between cannabis use and intraocular pressure, but its association with primary open-angle glaucoma (POAG) remains unclear. ...We used five single-nucleotide polymorphisms (SNPs) associate …
Several observational studies have investigated the association between cannabis use and intraocular pressure, but its …
A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.
Choquet H, Paylakhi S, Kneeland SC, Thai KK, Hoffmann TJ, Yin J, Kvale MN, Banda Y, Tolman NG, Williams PA, Schaefer C, Melles RB, Risch N, John SWM, Nair KS, Jorgenson E. Choquet H, et al. Nat Commun. 2018 Jun 11;9(1):2278. doi: 10.1038/s41467-018-04555-4. Nat Commun. 2018. PMID: 29891935 Free PMC article.
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the genetic risk remains unaccounted for, especially in African-Americans who have a higher risk for developing POAG. We conduct a multiethnic genome-wide association …
Primary open-angle glaucoma (POAG) is a leading cause of irreversible vision loss, yet much of the genetic risk remains unaccounted for, esp …
Relationships between Frailty and the Risk of Glaucoma in Middle-aged and Older Adults.
Chen J, Cao X, Zhuo X, Chen X, Ling Y, Wen Y, Ye G, Zhang Y, Zhan J, Tan H, Zhu Y, Zhuo Y. Chen J, et al. Ophthalmol Glaucoma. 2025 Jan-Feb;8(1):73-82. doi: 10.1016/j.ogla.2024.09.006. Epub 2024 Oct 5. Ophthalmol Glaucoma. 2025. PMID: 39370105
For the MR analysis, frailty genome-wide association study (GWAS) data were sourced from a UK Biobank and TwinGen meta-analysis, and GWAS data on glaucoma subtypes were derived from FinnGen. ...Mendelian randomization revealed that geneti …
For the MR analysis, frailty genome-wide association study (GWAS) data were sourced from a UK Biobank and TwinGe …
Genetic Associations of Primary Angle-Closure Disease: A Systematic Review and Meta-Analysis.
Liang YJ, Wang YY, Rong SS, Chen ZJ, Chen SY, Tham JA, Chan PP, Yam JC, Wiggs JL, Pang CP, Tham CC, Chen LJ. Liang YJ, et al. JAMA Ophthalmol. 2024 May 1;142(5):437-444. doi: 10.1001/jamaophthalmol.2024.0363. JAMA Ophthalmol. 2024. PMID: 38546604
SNV information was extracted from eligible reports and 2 genome-wide association studies summary statistics, UK BioBank and FinnGen. STUDY SELECTION: Studies providing analyzable genotype or allele data in a case-control design for primary angle-closu …
SNV information was extracted from eligible reports and 2 genome-wide association studies summary statistics, UK BioBan …
Genome-wide meta-analysis identifies 22 loci for normal tension glaucoma with significant overlap with high tension glaucoma.
Diaz-Torres S, He W, Yu R; IGGC International Glaucoma Genetics Consortium; Khawaja AP, Hammond CJ, Hysi PG, Pasquale LR, Wu Y, Kubo M, Akiyama M, Aung T, Cheng CY, Khor CC, Kraft P, Kang JH, Hewitt AW, Mackey DA, Craig JE, Wiggs JL, Ong JS, MacGregor S, Gharahkhani P. Diaz-Torres S, et al. Nat Commun. 2024 Nov 17;15(1):9959. doi: 10.1038/s41467-024-54301-2. Nat Commun. 2024. PMID: 39551815 Free PMC article.
Primary open-angle glaucoma typically presents as two subtypes. This study aimed to elucidate the shared and distinct genetic architectures of normal-tension (NTG) and high-tension glaucoma (HTG), motivated by the need to develop intraocular pressure (IOP)-in …
Primary open-angle glaucoma typically presents as two subtypes. This study aimed to elucidate the shared and distinct genetic archite …
30 results