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Genome-wide association study of prostate-specific antigen levels identifies novel loci independent of prostate cancer.
Hoffmann TJ, Passarelli MN, Graff RE, Emami NC, Sakoda LC, Jorgenson E, Habel LA, Shan J, Ranatunga DK, Quesenberry CP, Chao CR, Ghai NR, Aaronson D, Presti J, Nordström T, Wang Z, Berndt SI, Chanock SJ, Mosley JD, Klein RJ, Middha M, Lilja H, Melander O, Kvale MN, Kwok PY, Schaefer C, Risch N, Van Den Eeden SK, Witte JS. Hoffmann TJ, et al. Nat Commun. 2017 Jan 31;8:14248. doi: 10.1038/ncomms14248. Nat Commun. 2017. PMID: 28139693 Free PMC article.
Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cancer (PCa). However, factors other than PCa-such as genetics-can impact PSA. Here we present findings from a genome-wide a …
Prostate-specific antigen (PSA) levels have been used for detection and surveillance of prostate cance …
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups.
Hoffmann TJ, Graff RE, Madduri RK, Rodriguez AA, Cario CL, Feng K, Jiang Y, Wang A, Klein RJ, Pierce BL, Eggener S, Tong L, Blot W, Long J, Goss LB, Darst BF, Rebbeck T, Lachance J, Andrews C, Adebiyi AO, Adusei B, Aisuodionoe-Shadrach OI, Fernandez PW, Jalloh M, Janivara R, Chen WC, Mensah JE, Agalliu I, Berndt SI, Shelley JP, Schaffer K, Machiela MJ, Freedman ND, Huang WY, Li SA, Goodman PJ, Till C, Thompson I, Lilja H, Ranatunga DK, Presti J, Van Den Eeden SK, Chanock SJ, Mosley JD, Conti DV, Haiman CA, Justice AC, Kachuri L, Witte JS. Hoffmann TJ, et al. Nat Genet. 2025 Feb;57(2):334-344. doi: 10.1038/s41588-024-02068-z. Epub 2025 Feb 10. Nat Genet. 2025. PMID: 39930085 Free PMC article.
We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry, 58,236 African ancestry, 23,546 Hispanic/Latino and 3,630 Asian ancestry; 96.5% …
We conducted a multiancestry genome-wide association study of prostate-specific antigen (PS …
Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction.
Hoffmann TJ, Graff RE, Madduri RK, Rodriguez AA, Cario CL, Feng K, Jiang Y, Wang A, Klein RJ, Pierce BL, Eggener S, Tong L, Blot W, Long J, Goss LB, Darst BF, Rebbeck T, Lachance J, Andrews C, Adebiyi AO, Adusei B, Aisuodionoe-Shadrach OI, Fernandez PW, Jalloh M, Janivara R, Chen WC, Mensah JE, Agalliu I, Berndt SI, Shelley JP, Schaffer K, Machiela MJ, Freedman ND, Huang WY, Li SA, Goodman PJ, Till C, Thompson I, Lilja H, Ranatunga DK, Presti J, Van Den Eeden SK, Chanock SJ, Mosley JD, Conti DV, Haiman CA, Justice AC, Kachuri L, Witte JS. Hoffmann TJ, et al. medRxiv [Preprint]. 2024 Aug 20:2023.10.27.23297676. doi: 10.1101/2023.10.27.23297676. medRxiv. 2024. Update in: Nat Genet. 2025 Feb;57(2):334-344. doi: 10.1038/s41588-024-02068-z. PMID: 37961155 Free PMC article. Updated. Preprint.
We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of …
We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (P …
Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study.
Hishida A, Nakatochi M, Tamura T, Nagayoshi M, Okada R, Kubo Y, Tsukamoto M, Kadomatsu Y, Suzuki S, Nishiyama T, Kuriyama N, Watanabe I, Takezaki T, Nishimoto D, Kuriki K, Arisawa K, Katsuura-Kamano S, Mikami H, Kusakabe M, Oze I, Koyanagi YN, Nakamura Y, Kadota A, Shimanoe C, Tanaka K, Ikezaki H, Murata M, Kubo M, Momozawa Y, Takeuchi K, Wakai K; for the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study Group. Hishida A, et al. Nagoya J Med Sci. 2021 Feb;83(1):183-194. doi: 10.18999/nagjms.83.1.183. Nagoya J Med Sci. 2021. PMID: 33727749 Free PMC article.
Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified considerable numbers of human genetic factors associated with diseases. Several GWASs have reported significant loci associated with seru …
Recent advances in genetic epidemiology, including genome-wide association studies (GWASs), have identified cons …
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
Sun J, Tao S, Gao Y, Peng T, Tan A, Zhang H, Yang X, Qin X, Hu Y, Feng J, Kim ST, Lin X, Wu Y, Zhang J, Li Z, Li L, Mo L, Liang Z, Shi D, Huang Z, Huang X, Liu M, Liu Q, Zhang S, Lilly Zheng S, Xu J, Mo Z. Sun J, et al. Hum Genet. 2013 Apr;132(4):423-9. doi: 10.1007/s00439-012-1254-3. Epub 2012 Dec 27. Hum Genet. 2013. PMID: 23269536 Clinical Trial.
Prostate-specific antigen (PSA) is a commonly used cancer biomarker for prostate cancer, and is often included as part of routine physical examinations in China. Serum levels of PSA may be influenced by genetic factors as well as o …
Prostate-specific antigen (PSA) is a commonly used cancer biomarker for prostate cancer, and is of …