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Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.
Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Dufouil C, Bennett DA, Chibnik L, Cruchaga C, Del-Aguila J, Farrer LA, Mayeux R, Munsie L, Winslow A, Newhouse S, Saykin AJ, Kauwe JSK; Alzheimer's Disease Genetics Consortium; Crane PK, Green RC. Sherva R, et al. Alzheimers Dement. 2020 Aug;16(8):1134-1145. doi: 10.1002/alz.12106. Epub 2020 Jun 23. Alzheimers Dement. 2020. PMID: 32573913 Free PMC article.
INTRODUCTION: Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome-wide association study to examine rate of cognitive decline (ROD) in patients with …
INTRODUCTION: Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed …
Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease.
Eissman JM, Dumitrescu L, Mahoney ER, Smith AN, Mukherjee S, Lee ML, Scollard P, Choi SE, Bush WS, Engelman CD, Lu Q, Fardo DW, Trittschuh EH, Mez J, Kaczorowski CC, Hernandez Saucedo H, Widaman KF, Buckley RF, Properzi MJ, Mormino EC, Yang HS, Harrison TM, Hedden T, Nho K, Andrews SJ, Tommet D, Hadad N, Sanders RE, Ruderfer DM, Gifford KA, Zhong X, Raghavan NS, Vardarajan BN; Alzheimer’s Disease Neuroimaging Initiative (ADNI); Alzheimer’s Disease Genetics Consortium (ADGC); A4 Study Team; Pericak-Vance MA, Farrer LA, Wang LS, Cruchaga C, Schellenberg GD, Cox NJ, Haines JL, Keene CD, Saykin AJ, Larson EB, Sperling RA, Mayeux R, Cuccaro ML, Bennett DA, Schneider JA, Crane PK, Jefferson AL, Hohman TJ. Eissman JM, et al. Brain. 2022 Jul 29;145(7):2541-2554. doi: 10.1093/brain/awac177. Brain. 2022. PMID: 35552371 Free PMC article.
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer's
Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease
Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Aβ42 decline in non-demented elders.
Dou KX, Zhang C, Tan CC, Xu W, Li JQ, Cao XP, Tan L, Yu JT; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Dou KX, et al. Aging (Albany NY). 2019 Aug 1;11(15):5433-5444. doi: 10.18632/aging.102125. Epub 2019 Aug 1. Aging (Albany NY). 2019. PMID: 31370031 Free PMC article.
To identify the genetic determinants that regulate the rate of CSF Abeta(42) decline among non-demented elders, we conducted a genome-wide association study involved 321 non-demented elders from Alzheimer's Disease Ne …
To identify the genetic determinants that regulate the rate of CSF Abeta(42) decline among non-demented elders, we conducted a …
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC; GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Disease Genetics Consortium. Sherva R, et al. Alzheimers Dement. 2014 Jan;10(1):45-52. doi: 10.1016/j.jalz.2013.01.008. Epub 2013 Mar 25. Alzheimers Dement. 2014. PMID: 23535033 Free PMC article.
We describe the first genome-wide association study to examine rate of cognitive decline in a sample of AD patients with longitudinal measures of cognition. ...In the discovery sample, Alzheimer's Disease Asses …
We describe the first genome-wide association study to examine rate of cognitive decline in …
Genome-wide association study of hippocampal atrophy rate in non-demented elders.
Guo Y, Xu W, Li JQ, Ou YN, Shen XN, Huang YY, Dong Q, Tan L, Yu JT. Guo Y, et al. Aging (Albany NY). 2019 Nov 23;11(22):10468-10484. doi: 10.18632/aging.102470. Epub 2019 Nov 23. Aging (Albany NY). 2019. PMID: 31760383 Free PMC article.
Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear. Here we firstly performed a genome-wide association study (GWAS) to identify genetic loci that regulate hippocampal at …
Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear. Here w …
Genome-Wide Association Study Identifies SLAMF1 Affecting the Rate of Memory Decline.
Chen SD, Li HQ, Shen XN, Li JQ, Xu W, Huang YY, Tan L, Dong Q, Yu JT; Alzheimer’s Disease Neuroimaging Initiative. Chen SD, et al. J Alzheimers Dis. 2020;74(1):139-149. doi: 10.3233/JAD-191214. J Alzheimers Dis. 2020. PMID: 31985465
OBJECTIVE: We performed a genome-wide association study (GWAS) focusing on memory function to explore single nucleotide polymorphisms (SNPs) associated with the rate of memory decline. METHODS: Seven hundred and nine eligible non-Hispanic …
OBJECTIVE: We performed a genome-wide association study (GWAS) focusing on memory function to explore single nuc …
Genome-wide association studies: is there a genotype for cognitive decline in older persons with type 2 diabetes?
Abbatecola AM, Olivieri F, Corsonello A, Antonicelli R, Corica F, Lattanzio F. Abbatecola AM, et al. Curr Pharm Des. 2011;17(4):347-56. doi: 10.2174/138161211795164239. Curr Pharm Des. 2011. PMID: 21352095 Review.
There is a dramatic increase in the number of elderly persons on a worldwide scale with an increase in chronic comorbidities, especially type 2 diabetes (T2DM) and dementia. Although cognitive faculties commonly deteriorate in non-diabetic persons as they age, several stud …
There is a dramatic increase in the number of elderly persons on a worldwide scale with an increase in chronic comorbidities, especially typ …
Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders.
Li X, Chu SG, Shen XN, Hou XH, Xu W, Ou YN, Dong Q, Tan L, Yu JT. Li X, et al. Aging (Albany NY). 2019 Nov 11;11(21):9862-9874. doi: 10.18632/aging.102435. Epub 2019 Nov 11. Aging (Albany NY). 2019. PMID: 31711042 Free PMC article.
Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases. A large genome-wide association study (GWAS) has identified seven loci associated with ventricular volume. ...We performed a GWAS of the rate of ventricular en …
Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases. A large genome-wide association
PSEN1 polymorphisms alter the rate of cognitive decline in sporadic Alzheimer's disease patients.
Belbin O, Beaumont H, Warden D, Smith AD, Kalsheker N, Morgan K. Belbin O, et al. Neurobiol Aging. 2009 Dec;30(12):1992-9. doi: 10.1016/j.neurobiolaging.2008.02.013. Epub 2008 Apr 9. Neurobiol Aging. 2009. PMID: 18403054
Mutations in amyloid precursor protein (APP) and presenilin (PSEN) genes are known to cause familial early-onset Alzheimer's disease (AD), which account for around 5% of AD cases. ...No other single SNPs or haplotypes were associated with AD risk. However, 3 …
Mutations in amyloid precursor protein (APP) and presenilin (PSEN) genes are known to cause familial early-onset Alzheimer's
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study.
Andrews SJ, Das D, Anstey KJ, Easteal S. Andrews SJ, et al. J Alzheimers Dis. 2017;57(2):423-436. doi: 10.3233/JAD-160774. J Alzheimers Dis. 2017. PMID: 28269768
Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late onset Alzheimer's disease (LOAD). ...Our results suggest that a minority of AD related SNPs may be associated with non …
Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late …
41 results