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Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways.
Sherva R, Gross A, Mukherjee S, Koesterer R, Amouyel P, Bellenguez C, Dufouil C, Bennett DA, Chibnik L, Cruchaga C, Del-Aguila J, Farrer LA, Mayeux R, Munsie L, Winslow A, Newhouse S, Saykin AJ, Kauwe JSK; Alzheimer's Disease Genetics Consortium, Crane PK, Green RC. Sherva R, et al. Alzheimers Dement. 2020 Aug;16(8):1134-1145. doi: 10.1002/alz.12106. Epub 2020 Jun 23. Alzheimers Dement. 2020. PMID: 32573913
INTRODUCTION: Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed a genome-wide association study to examine rate of cognitive decline (ROD) in patients with …
INTRODUCTION: Variability exists in the disease trajectories of Alzheimer's disease (AD) patients. We performed …
Genome-wide association study identifies CBFA2T3 affecting the rate of CSF Abeta(42) decline in non-demented elders.
Dou KX, Zhang C, Tan CC, Xu W, Li JQ, Cao XP, Tan L, Yu JT; Alzheimer’s Disease Neuroimaging Initiative (ADNI). Dou KX, et al. Aging (Albany NY). 2019 Aug 1;11(15):5433-5444. doi: 10.18632/aging.102125. Epub 2019 Aug 1. Aging (Albany NY). 2019. PMID: 31370031 Free PMC article.
To identify the genetic determinants that regulate the rate of CSF Abeta(42) decline among non-demented elders, we conducted a genome-wide association study involved 321 non-demented elders from Alzheimer's Disease Ne …
To identify the genetic determinants that regulate the rate of CSF Abeta(42) decline among non-demented elders, we conducted a …
Genome-wide association study of hippocampal atrophy rate in non-demented elders.
Guo Y, Xu W, Li JQ, Ou YN, Shen XN, Huang YY, Dong Q, Tan L, Yu JT. Guo Y, et al. Aging (Albany NY). 2019 Nov 23;11(22):10468-10484. doi: 10.18632/aging.102470. Epub 2019 Nov 23. Aging (Albany NY). 2019. PMID: 31760383 Free PMC article.
Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear. Here we firstly performed a genome-wide association study (GWAS) to identify genetic loci that regulate hippocampal at …
Hippocampal atrophy rate has been correlated with cognitive decline and its genetic modifiers are still unclear. Here w …
A meta-analysis of genome-wide association studies of epigenetic age acceleration.
Gibson J, Russ TC, Clarke TK, Howard DM, Hillary RF, Evans KL, Walker RM, Bermingham ML, Morris SW, Campbell A, Hayward C, Murray AD, Porteous DJ, Horvath S, Lu AT, McIntosh AM, Whalley HC, Marioni RE. Gibson J, et al. PLoS Genet. 2019 Nov 18;15(11):e1008104. doi: 10.1371/journal.pgen.1008104. eCollection 2019 Nov. PLoS Genet. 2019. PMID: 31738745 Free PMC article.
Two commonly used measures, derived from DNA methylation, are Horvath-based (Horvath-EAA) and Hannum-based (Hannum-EAA) epigenetic age acceleration. We conducted genome-wide association studies of Horvath-EAA and Hannum-EAA in 13,493 unrelated individuals of …
Two commonly used measures, derived from DNA methylation, are Horvath-based (Horvath-EAA) and Hannum-based (Hannum-EAA) epigenetic age accel …
Genome-Wide Association Study Identifies SLAMF1 Affecting the Rate of Memory Decline.
Chen SD, Li HQ, Shen XN, Li JQ, Xu W, Huang YY, Tan L, Dong Q, Yu JT; Alzheimer’s Disease Neuroimaging Initiative. Chen SD, et al. J Alzheimers Dis. 2020;74(1):139-149. doi: 10.3233/JAD-191214. J Alzheimers Dis. 2020. PMID: 31985465
OBJECTIVE: We performed a genome-wide association study (GWAS) focusing on memory function to explore single nucleotide polymorphisms (SNPs) associated with the rate of memory decline. METHODS: Seven hundred and nine eligible non-Hispanic …
OBJECTIVE: We performed a genome-wide association study (GWAS) focusing on memory function to explore single nuc …
Genome-wide association study identifies SIAH3 locus influencing the rate of ventricular enlargement in non-demented elders.
Li X, Chu SG, Shen XN, Hou XH, Xu W, Ou YN, Dong Q, Tan L, Yu JT. Li X, et al. Aging (Albany NY). 2019 Nov 11;11(21):9862-9874. doi: 10.18632/aging.102435. Epub 2019 Nov 11. Aging (Albany NY). 2019. PMID: 31711042 Free PMC article.
Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases. A large genome-wide association study (GWAS) has identified seven loci associated with ventricular volume. ...We performed a GWAS of the rate of ventricular en …
Ventricular enlargement occurs in several neurodegenerative and psychiatric diseases. A large genome-wide association
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
Sherva R, Tripodis Y, Bennett DA, Chibnik LB, Crane PK, de Jager PL, Farrer LA, Saykin AJ, Shulman JM, Naj A, Green RC; GENAROAD Consortium; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Disease Genetics Consortium. Sherva R, et al. Alzheimers Dement. 2014 Jan;10(1):45-52. doi: 10.1016/j.jalz.2013.01.008. Epub 2013 Mar 25. Alzheimers Dement. 2014. PMID: 23535033 Free PMC article.
We describe the first genome-wide association study to examine rate of cognitive decline in a sample of AD patients with longitudinal measures of cognition. ...In the discovery sample, Alzheimer's Disease Asses …
We describe the first genome-wide association study to examine rate of cognitive decline in …
Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression.
Steffens DC, Garrett ME, Soldano KL, McQuoid DR, Ashley-Koch AE, Potter GG. Steffens DC, et al. Int Psychogeriatr. 2020 Jul 9:1-9. doi: 10.1017/S1041610220001143. Online ahead of print. Int Psychogeriatr. 2020. PMID: 32641180
DESIGN: A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elderly (NCODE) study. ...MEASUREMENTS: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neuro …
DESIGN: A genome-wide association study (GWAS) analysis in the Neurocognitive Outcomes of Depression in the Elde …
Neuropathological correlates and genetic architecture of microglial activation in elderly human brain.
Felsky D, Roostaei T, Nho K, Risacher SL, Bradshaw EM, Petyuk V, Schneider JA, Saykin A, Bennett DA, De Jager PL. Felsky D, et al. Nat Commun. 2019 Jan 24;10(1):409. doi: 10.1038/s41467-018-08279-3. Nat Commun. 2019. PMID: 30679421 Free PMC article.
Here we report that the proportion of morphologically activated microglia (PAM) in postmortem cortical tissue is strongly associated with beta-amyloid, tau-related neuropathology, and the rate of cognitive decline. Effect sizes for PAM measures are substantia …
Here we report that the proportion of morphologically activated microglia (PAM) in postmortem cortical tissue is strongly associated with be …
Late Onset Alzheimer's Disease Risk Variants in Cognitive Decline: The PATH Through Life Study.
Andrews SJ, Das D, Anstey KJ, Easteal S. Andrews SJ, et al. J Alzheimers Dis. 2017;57(2):423-436. doi: 10.3233/JAD-160774. J Alzheimers Dis. 2017. PMID: 28269768
Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late onset Alzheimer's disease (LOAD). ...Our results suggest that a minority of AD related SNPs may be associated with non …
Recent genome wide association studies have identified a number of single nucleotide polymorphisms associated with late …
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