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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2001 1
2002 1
2003 2
2004 4
2005 5
2007 2
2008 4
2009 9
2010 8
2011 4
2012 13
2013 14
2014 17
2015 32
2016 44
2017 61
2018 68
2019 64
2020 22
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330 results
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Page 1
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
Tiriac H, Belleau P, Engle DD, Plenker D, Deschênes A, Somerville TDD, Froeling FEM, Burkhart RA, Denroche RE, Jang GH, Miyabayashi K, Young CM, Patel H, Ma M, LaComb JF, Palmaira RLD, Javed AA, Huynh JC, Johnson M, Arora K, Robine N, Shah M, Sanghvi R, Goetz AB, Lowder CY, Martello L, Driehuis E, LeComte N, Askan G, Iacobuzio-Donahue CA, Clevers H, Wood LD, Hruban RH, Thompson E, Aguirre AJ, Wolpin BM, Sasson A, Kim J, Wu M, Bucobo JC, Allen P, Sejpal DV, Nealon W, Sullivan JD, Winter JM, Gimotty PA, Grem JL, DiMaio DJ, Buscaglia JM, Grandgenett PM, Brody JR, Hollingsworth MA, O'Kane GM, Notta F, Kim E, Crawford JM, Devoe C, Ocean A, Wolfgang CL, Yu KH, Li E, Vakoc CR, Hubert B, Fischer SE, Wilson JM, Moffitt R, Knox J, Krasnitz A, Gallinger S, Tuveson DA. Tiriac H, et al. Cancer Discov. 2018 Sep;8(9):1112-1129. doi: 10.1158/2159-8290.CD-18-0349. Epub 2018 May 31. Cancer Discov. 2018. PMID: 29853643 Free PMC article.
PDOs exhibited heterogeneous responses to standard-of-care chemotherapeutics and investigational agents. In a case study manner, we found that PDO therapeutic profiles paralleled patient outcomes and that PDOs enabled longitudinal assessment of chemosensitivity and …
PDOs exhibited heterogeneous responses to standard-of-care chemotherapeutics and investigational agents. In a case study manner, we f …
Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non-Small Cell Lung Cancer Using a Clinicogenomic Database.
Singal G, Miller PG, Agarwala V, Li G, Kaushik G, Backenroth D, Gossai A, Frampton GM, Torres AZ, Lehnert EM, Bourque D, O'Connell C, Bowser B, Caron T, Baydur E, Seidl-Rathkopf K, Ivanov I, Alpha-Cobb G, Guria A, He J, Frank S, Nunnally AC, Bailey M, Jaskiw A, Feuchtbaum D, Nussbaum N, Abernethy AP, Miller VA. Singal G, et al. JAMA. 2019 Apr 9;321(14):1391-1399. doi: 10.1001/jama.2019.3241. JAMA. 2019. PMID: 30964529 Free PMC article.
IMPORTANCE: Data sets linking comprehensive genomic profiling (CGP) to clinical outcomes may accelerate precision medicine. OBJECTIVE: To assess whether a database that combines EHR-derived clinical data with CGP can identify and extend associations in non-small cel …
IMPORTANCE: Data sets linking comprehensive genomic profiling (CGP) to clinical outcomes may accelerate precision medicine. OB …
Genetic counselling in the era of genomic medicine.
Patch C, Middleton A. Patch C, et al. Br Med Bull. 2018 Jun 1;126(1):27-36. doi: 10.1093/bmb/ldy008. Br Med Bull. 2018. PMID: 29617718 Free PMC article. Review.
BACKGROUND: Genomic technology can now deliver cost effective, targeted diagnosis and treatment for patients. Genetic counselling is a communication process empowering patients and families to make autonomous decisions and effectively use new genetic information
BACKGROUND: Genomic technology can now deliver cost effective, targeted diagnosis and treatment for patients. Genetic counsell …
Building evidence and measuring clinical outcomes for genomic medicine.
Peterson JF, Roden DM, Orlando LA, Ramirez AH, Mensah GA, Williams MS. Peterson JF, et al. Lancet. 2019 Aug 17;394(10198):604-610. doi: 10.1016/S0140-6736(19)31278-4. Epub 2019 Aug 5. Lancet. 2019. PMID: 31395443 Review.
Human genomic sequencing has potential diagnostic, prognostic, and therapeutic value across a wide breadth of clinical disciplines. ...In this Series paper, we review clinical outcome studies in genomic medicine and discuss the important features and key chal …
Human genomic sequencing has potential diagnostic, prognostic, and therapeutic value across a wide breadth of clinical disciplines. . …
Machine learning in cardiovascular medicine: are we there yet?
Shameer K, Johnson KW, Glicksberg BS, Dudley JT, Sengupta PP. Shameer K, et al. Heart. 2018 Jul;104(14):1156-1164. doi: 10.1136/heartjnl-2017-311198. Epub 2018 Jan 19. Heart. 2018. PMID: 29352006 Review.
The most promising avenues for AI in medicine are the development of automated risk prediction algorithms which can be used to guide clinical care; use of unsupervised learning techniques to more precisely phenotype complex disease; and the implementation of reinfor …
The most promising avenues for AI in medicine are the development of automated risk prediction algorithms which can be used to guide …
Information technology and precision medicine.
Carney PH. Carney PH. Semin Oncol Nurs. 2014 May;30(2):124-9. doi: 10.1016/j.soncn.2014.03.006. Semin Oncol Nurs. 2014. PMID: 24794086 Review.
OBJECTIVES: To provide oncology nurses with an overview of clinical decision support (CDS) and explore opportunities for genomic CDS interventions. ...DATA SOURCES: Published nursing and medical literature and the internet for an exemplar. CONCLUSION: CDS is a sophi …
OBJECTIVES: To provide oncology nurses with an overview of clinical decision support (CDS) and explore opportunities for genomic CDS …
Standards and Guidelines for Validating Next-Generation Sequencing Bioinformatics Pipelines: A Joint Recommendation of the Association for Molecular Pathology and the College of American Pathologists.
Roy S, Coldren C, Karunamurthy A, Kip NS, Klee EW, Lincoln SE, Leon A, Pullambhatla M, Temple-Smolkin RL, Voelkerding KV, Wang C, Carter AB. Roy S, et al. J Mol Diagn. 2018 Jan;20(1):4-27. doi: 10.1016/j.jmoldx.2017.11.003. Epub 2017 Nov 21. J Mol Diagn. 2018. PMID: 29154853 Free article. Review.
Processing raw sequence data to detect genomic alterations has significant impact on disease management and patient care. Because of the lack of published guidance, there is currently a high degree of variability in how members of the global molecular genetic …
Processing raw sequence data to detect genomic alterations has significant impact on disease management and patient care
Precision Medicine in Oncology Pharmacy Practice.
Saadeh C, Bright D, Rustem D. Saadeh C, et al. Acta Med Acad. 2019 Apr;48(1):90-104. doi: 10.5644/ama2006-124.246. Acta Med Acad. 2019. PMID: 31264437 Free article. Review.
Genomic assays of patient tumors is now the standard of care in oncology and recommendations for targeted drug therapies are often formulated by interprofessional teams. ...Examples include: OncoKB is a precision oncology knowledge base that offers evidence-b
Genomic assays of patient tumors is now the standard of care in oncology and recommendations for targeted drug therapie
Pharmacogenomic landscape of patient-derived tumor cells informs precision oncology therapy.
Lee JK, Liu Z, Sa JK, Shin S, Wang J, Bordyuh M, Cho HJ, Elliott O, Chu T, Choi SW, Rosenbloom DIS, Lee IH, Shin YJ, Kang HJ, Kim D, Kim SY, Sim MH, Kim J, Lee T, Seo YJ, Shin H, Lee M, Kim SH, Kwon YJ, Oh JW, Song M, Kim M, Kong DS, Choi JW, Seol HJ, Lee JI, Kim ST, Park JO, Kim KM, Song SY, Lee JW, Kim HC, Lee JE, Choi MG, Seo SW, Shim YM, Zo JI, Jeong BC, Yoon Y, Ryu GH, Kim NKD, Bae JS, Park WY, Lee J, Verhaak RGW, Iavarone A, Lee J, Rabadan R, Nam DH. Lee JK, et al. Nat Genet. 2018 Oct;50(10):1399-1411. doi: 10.1038/s41588-018-0209-6. Epub 2018 Sep 27. Nat Genet. 2018. PMID: 30262818
The fundamental tenet of precision oncology defines molecular characterization of tumors to guide optimal patient-tailored therapy. Towards this goal, we have established a compilation of pharmacological landscapes of 462 patient-derived tumor cells (PDCs) across 14 …
The fundamental tenet of precision oncology defines molecular characterization of tumors to guide optimal patient-tailored therapy. T …
Genomic Information for Clinicians in the Electronic Health Record: Lessons Learned From the Clinical Genome Resource Project and the Electronic Medical Records and Genomics Network.
Williams MS, Taylor CO, Walton NA, Goehringer SR, Aronson S, Freimuth RR, Rasmussen LV, Hall ES, Prows CA, Chung WK, Fedotov A, Nestor J, Weng C, Rowley RK, Wiesner GL, Jarvik GP, Del Fiol G. Williams MS, et al. Front Genet. 2019 Oct 29;10:1059. doi: 10.3389/fgene.2019.01059. eCollection 2019. Front Genet. 2019. PMID: 31737042 Free PMC article.
Genomic knowledge is being translated into clinical care. To fully realize the value, it is critical to place credible information in the hands of clinicians in time to support clinical decision making. The electronic health record is an essential comp
Genomic knowledge is being translated into clinical care. To fully realize the value, it is critical to place credible info
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