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Genomic risk scores for juvenile idiopathic arthritis and its subtypes.
Cánovas R, Cobb J, Brozynska M, Bowes J, Li YR, Smith SL, Hakonarson H, Thomson W, Ellis JA, Abraham G, Munro JE, Inouye M. Cánovas R, et al. Ann Rheum Dis. 2020 Dec;79(12):1572-1579. doi: 10.1136/annrheumdis-2020-217421. Epub 2020 Sep 4. Ann Rheum Dis. 2020. PMID: 32887683 Free PMC article.
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in children. ...Despite JIA having substantial heritability, the construction of genomic risk scores (GRSs) to aid or expedi …
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in ch …
Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.
López-Isac E, Smith SL, Marion MC, Wood A, Sudman M, Yarwood A, Shi C, Gaddi VP, Martin P, Prahalad S, Eyre S, Orozco G, Morris AP, Langefeld CD, Thompson SD, Thomson W, Bowes J. López-Isac E, et al. Ann Rheum Dis. 2020 Oct 26;80(3):321-8. doi: 10.1136/annrheumdis-2020-218481. Online ahead of print. Ann Rheum Dis. 2020. PMID: 33106285 Free PMC article.
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. Our understanding of the genetic risk factors for this disease is limited due to low disease prevalence and extensive clinical heter …
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. Our un …
Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients.
Nikopensius T, Niibo P, Haller T, Jagomägi T, Voog-Oras Ü, Tõnisson N, Metspalu A, Saag M, Pruunsild C. Nikopensius T, et al. Clin Rheumatol. 2021 Oct;40(10):4157-4165. doi: 10.1007/s10067-021-05756-x. Epub 2021 Jun 8. Clin Rheumatol. 2021. PMID: 34101054 Free PMC article.
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. ...Key Points Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease with heterogeneous presentation …
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. ...Key Poi …
Genetics of juvenile idiopathic arthritis: new tools bring new approaches.
Moncrieffe H, Prahalad S, Thompson SD. Moncrieffe H, et al. Curr Opin Rheumatol. 2014 Sep;26(5):579-84. doi: 10.1097/BOR.0000000000000094. Curr Opin Rheumatol. 2014. PMID: 25010442 Free PMC article. Review.
PURPOSE OF REVIEW: In juvenile idiopathic arthritis (JIA), there are now more than 25 regions represented by single nucleotide polymorphisms that show strong genetic associations. ...Recent technological advances in high throughput sequencing, chromatin struc …
PURPOSE OF REVIEW: In juvenile idiopathic arthritis (JIA), there are now more than 25 regions represented by single nuc …
Oligoarticular and polyarticular JIA: epidemiology and pathogenesis.
Macaubas C, Nguyen K, Milojevic D, Park JL, Mellins ED. Macaubas C, et al. Nat Rev Rheumatol. 2009 Nov;5(11):616-26. doi: 10.1038/nrrheum.2009.209. Epub 2009 Oct 6. Nat Rev Rheumatol. 2009. PMID: 19806151 Free PMC article. Review.
Juvenile idiopathic arthritis (JIA) refers to a group of chronic childhood arthropathies of unknown etiology, currently classified into subtypes primarily on the basis of clinical features. ...Non-HLA genetic risk factors have also been i
Juvenile idiopathic arthritis (JIA) refers to a group of chronic childhood arthropathies of unknown etiology, currently
Juvenile idiopathic arthritis subtype- and sex-specific associations with genetic variants in the PSMA6/PSMC6/PSMA3 gene cluster.
Sjakste T, Paramonova N, Rumba-Rozenfelde I, Trapina I, Sugoka O, Sjakste N. Sjakste T, et al. Pediatr Neonatol. 2014 Oct;55(5):393-403. doi: 10.1016/j.pedneo.2014.01.007. Epub 2014 May 27. Pediatr Neonatol. 2014. PMID: 24875235 Free article.
BACKGROUND: The ubiquitin proteasome system plays an exceptional biological role in the antigen processing and immune response and it could potentially be involved in pathogenesis of many immunity-related diseases, including juvenile idiopathic arthritis (JIA …
BACKGROUND: The ubiquitin proteasome system plays an exceptional biological role in the antigen processing and immune response and it could …
The impact of single nucleotide polymorphisms in ADORA2A and ADORA3 genes on the early response to methotrexate and presence of therapy side effects in children with juvenile idiopathic arthritis: Results of a preliminary study.
Roszkiewicz J, Michałek D, Ryk A, Swacha Z, Szmyd B, Smolewska E. Roszkiewicz J, et al. Int J Rheum Dis. 2020 Nov;23(11):1505-1513. doi: 10.1111/1756-185X.13972. Epub 2020 Sep 23. Int J Rheum Dis. 2020. PMID: 32969158
AIM: Methotrexate (MTX) administered at the dose 10-15 mg/m(2) is recommended as the first-line therapy in most juvenile idiopathic arthritis (JIA) subtypes. The disease-modifying effect of methotrexate is associated with release of adenosine and media …
AIM: Methotrexate (MTX) administered at the dose 10-15 mg/m(2) is recommended as the first-line therapy in most juvenile idiopathi
Disease-specific regulation of gene expression in a comparative analysis of juvenile idiopathic arthritis and inflammatory bowel disease.
Mo A, Marigorta UM, Arafat D, Chan LHK, Ponder L, Jang SR, Prince J, Kugathasan S, Prahalad S, Gibson G. Mo A, et al. Genome Med. 2018 Jun 27;10(1):48. doi: 10.1186/s13073-018-0558-x. Genome Med. 2018. PMID: 29950172 Free PMC article.
METHODS: We performed RNA-Seq on whole blood samples from 202 patients with oligoarticular, polyarticular, or systemic juvenile idiopathic arthritis, or with Crohn's disease or ulcerative colitis, as well as healthy controls, to characterize difference …
METHODS: We performed RNA-Seq on whole blood samples from 202 patients with oligoarticular, polyarticular, or systemic juvenile id
Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.
McIntosh LA, Marion MC, Sudman M, Comeau ME, Becker ML, Bohnsack JF, Fingerlin TE, Griffin TA, Haas JP, Lovell DJ, Maier LA, Nigrovic PA, Prahalad S, Punaro M, Rosé CD, Wallace CA, Wise CA, Moncrieffe H, Howard TD, Langefeld CD, Thompson SD. McIntosh LA, et al. Arthritis Rheumatol. 2017 Nov;69(11):2222-2232. doi: 10.1002/art.40216. Epub 2017 Oct 12. Arthritis Rheumatol. 2017. PMID: 28719732 Free PMC article.
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and has a strong genomic component. ...Furthermore, associated SNPs included cis expression quantitative trait loci for WDFY4, CCDC12, MTP18, SF3A1, AHI1, COG …
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and has a strong genom
Recent advances in the immunogenetics of idiopathic inflammatory myopathy.
Chinoy H, Lamb JA, Ollier WE, Cooper RG. Chinoy H, et al. Arthritis Res Ther. 2011 May 26;13(3):216. doi: 10.1186/ar3327. Arthritis Res Ther. 2011. PMID: 21658295 Free PMC article. Review.
A substantial part of the genetic risk for developing adult- and juvenile-onset IIM lies within the major histocompatibility complex (MHC), and a tight relationship exists between individual human leukocyte antigen alleles and specific serological subtypes, w …
A substantial part of the genetic risk for developing adult- and juvenile-onset IIM lies within the major histocompatibility c …
24 results