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Genomic risk scores for juvenile idiopathic arthritis and its subtypes.
Cánovas R, Cobb J, Brozynska M, Bowes J, Li YR, Smith SL, Hakonarson H, Thomson W, Ellis JA, Abraham G, Munro JE, Inouye M. Cánovas R, et al. Ann Rheum Dis. 2020 Dec;79(12):1572-1579. doi: 10.1136/annrheumdis-2020-217421. Epub 2020 Sep 4. Ann Rheum Dis. 2020. PMID: 32887683 Free PMC article.
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in children. ...Despite JIA having substantial heritability, the construction of genomic risk scores (GRSs) to aid or expedi …
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is an autoimmune disease and a common cause of chronic disability in ch …
Genetics of juvenile idiopathic arthritis: new tools bring new approaches.
Moncrieffe H, Prahalad S, Thompson SD. Moncrieffe H, et al. Curr Opin Rheumatol. 2014 Sep;26(5):579-84. doi: 10.1097/BOR.0000000000000094. Curr Opin Rheumatol. 2014. PMID: 25010442 Free PMC article. Review.
PURPOSE OF REVIEW: In juvenile idiopathic arthritis (JIA), there are now more than 25 regions represented by single nucleotide polymorphisms that show strong genetic associations. ...Recent technological advances in high throughput sequencing, chromatin struc …
PURPOSE OF REVIEW: In juvenile idiopathic arthritis (JIA), there are now more than 25 regions represented by single nuc …
Combined genetic analysis of juvenile idiopathic arthritis clinical subtypes identifies novel risk loci, target genes and key regulatory mechanisms.
López-Isac E, Smith SL, Marion MC, Wood A, Sudman M, Yarwood A, Shi C, Gaddi VP, Martin P, Prahalad S, Eyre S, Orozco G, Morris AP, Langefeld CD, Thompson SD, Thomson W, Bowes J. López-Isac E, et al. Ann Rheum Dis. 2021 Mar;80(3):321-328. doi: 10.1136/annrheumdis-2020-218481. Epub 2020 Oct 26. Ann Rheum Dis. 2021. PMID: 33106285 Free PMC article.
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. Our understanding of the genetic risk factors for this disease is limited due to low disease prevalence and extensive clinical heter …
OBJECTIVES: Juvenile idiopathic arthritis (JIA) is the most prevalent form of juvenile rheumatic disease. Our un …
Shared genomic segments analysis identifies MHC class I and class III molecules as genetic risk factors for juvenile idiopathic arthritis.
Avery CN, Russell ND, Steely CJ, Hersh AO, Bohnsack JF, Prahalad S, Jorde LB. Avery CN, et al. HGG Adv. 2024 Apr 11;5(2):100277. doi: 10.1016/j.xhgg.2024.100277. Epub 2024 Feb 18. HGG Adv. 2024. PMID: 38369753 Free PMC article.
Juvenile idiopathic arthritis (JIA) is a complex rheumatic disease encompassing several clinically defined subtypes of varying severity. ...Continued investigation of heritable risk factors has been hindered by disease heterogeneity and l …
Juvenile idiopathic arthritis (JIA) is a complex rheumatic disease encompassing several clinically defined subtypes …
Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients.
Nikopensius T, Niibo P, Haller T, Jagomägi T, Voog-Oras Ü, Tõnisson N, Metspalu A, Saag M, Pruunsild C. Nikopensius T, et al. Clin Rheumatol. 2021 Oct;40(10):4157-4165. doi: 10.1007/s10067-021-05756-x. Epub 2021 Jun 8. Clin Rheumatol. 2021. PMID: 34101054 Free PMC article.
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. ...The reported loci are involved in molecular pathways of immunological relevance and likely represent genomic regions that confer susceptibil …
BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. ...The rep …
Juvenile idiopathic arthritis and HLA class I and class II interactions and age-at-onset effects.
Hollenbach JA, Thompson SD, Bugawan TL, Ryan M, Sudman M, Marion M, Langefeld CD, Thomson G, Erlich HA, Glass DN. Hollenbach JA, et al. Arthritis Rheum. 2010 Jun;62(6):1781-91. doi: 10.1002/art.27424. Arthritis Rheum. 2010. PMID: 20191588 Free PMC article.
OBJECTIVE: The aim of this study was to quantitate risk and to examine heterogeneity for HLA at high resolution in patients with the most common subtypes of juvenile idiopathic arthritis (JIA), IgM rheumatoid factor-negative polyarticular JIA an …
OBJECTIVE: The aim of this study was to quantitate risk and to examine heterogeneity for HLA at high resolution in patients with the …
Juvenile idiopathic arthritis subtype- and sex-specific associations with genetic variants in the PSMA6/PSMC6/PSMA3 gene cluster.
Sjakste T, Paramonova N, Rumba-Rozenfelde I, Trapina I, Sugoka O, Sjakste N. Sjakste T, et al. Pediatr Neonatol. 2014 Oct;55(5):393-403. doi: 10.1016/j.pedneo.2014.01.007. Epub 2014 May 27. Pediatr Neonatol. 2014. PMID: 24875235 Free article.
BACKGROUND: The ubiquitin proteasome system plays an exceptional biological role in the antigen processing and immune response and it could potentially be involved in pathogenesis of many immunity-related diseases, including juvenile idiopathic arthritis (JIA …
BACKGROUND: The ubiquitin proteasome system plays an exceptional biological role in the antigen processing and immune response and it could …
Genetic association of antinuclear antibodies with HLA in JIA patients: a Swedish cohort study.
Saleh R, Sundberg E, Olsson M, Tengvall K, Alfredsson L, Kockum I, Padyukov L, Harris HE. Saleh R, et al. Pediatr Rheumatol Online J. 2024 Aug 26;22(1):79. doi: 10.1186/s12969-024-01017-8. Pediatr Rheumatol Online J. 2024. PMID: 39187888 Free PMC article.
BACKGROUND: Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disease and the most common chronic rheumatological disease affecting children under the age of 16. ...HLA-DRB1*08:01, HLA-DQA1*04:01, and HLA-DQB1*04:02 were the haplotypes most strongly …
BACKGROUND: Juvenile Idiopathic Arthritis (JIA) is a complex autoimmune disease and the most common chronic rheumatolog …
Genome-Wide Association Meta-Analysis Reveals Novel Juvenile Idiopathic Arthritis Susceptibility Loci.
McIntosh LA, Marion MC, Sudman M, Comeau ME, Becker ML, Bohnsack JF, Fingerlin TE, Griffin TA, Haas JP, Lovell DJ, Maier LA, Nigrovic PA, Prahalad S, Punaro M, Rosé CD, Wallace CA, Wise CA, Moncrieffe H, Howard TD, Langefeld CD, Thompson SD. McIntosh LA, et al. Arthritis Rheumatol. 2017 Nov;69(11):2222-2232. doi: 10.1002/art.40216. Epub 2017 Oct 12. Arthritis Rheumatol. 2017. PMID: 28719732 Free PMC article.
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and has a strong genomic component. ...CONCLUSION: This study provides evidence of both unique JIA risk loci and risk loci overlapping between J …
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic disease and has a strong genom …
Oligoarticular and polyarticular JIA: epidemiology and pathogenesis.
Macaubas C, Nguyen K, Milojevic D, Park JL, Mellins ED. Macaubas C, et al. Nat Rev Rheumatol. 2009 Nov;5(11):616-26. doi: 10.1038/nrrheum.2009.209. Epub 2009 Oct 6. Nat Rev Rheumatol. 2009. PMID: 19806151 Free PMC article. Review.
Juvenile idiopathic arthritis (JIA) refers to a group of chronic childhood arthropathies of unknown etiology, currently classified into subtypes primarily on the basis of clinical features. ...Non-HLA genetic risk factors have also been i …
Juvenile idiopathic arthritis (JIA) refers to a group of chronic childhood arthropathies of unknown etiology, currently …
28 results