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Genotoxicity assessment of the flavouring agent, perillaldehyde.
Hobbs CA, Taylor SV, Beevers C, Lloyd M, Bowen R, Lillford L, Maronpot R, Hayashi SM. Hobbs CA, et al. Food Chem Toxicol. 2016 Nov;97:232-242. doi: 10.1016/j.fct.2016.08.029. Epub 2016 Sep 1. Food Chem Toxicol. 2016. PMID: 27593899 Free article.
To confirm the safety of flavourings placed on the European Union list of flavourings, perillaldehyde was selected by the European Food Safety Authority as a representative of a subgroup of alicyclic aldehyde flavouring substances to be evaluated for genotoxic
To confirm the safety of flavourings placed on the European Union list of flavourings, perillaldehyde was selected by the European Fo …
Role of pathology peer review in interpretation of the comet assay.
Maronpot RR, Hobbs CA, Hayashi SM. Maronpot RR, et al. J Toxicol Pathol. 2018 Jul;31(3):155-161. doi: 10.1293/tox.2018-0019. Epub 2018 May 11. J Toxicol Pathol. 2018. PMID: 30093784 Free PMC article. Review.
Since the comet assay typically uses only two or three daily doses of test agent, precursor tissue changes indicative of toxicity may be easily overlooked. Using case examples for two flavoring agents, perillaldehyde and 4,5-epoxydec-2(trans)-enal, we …
Since the comet assay typically uses only two or three daily doses of test agent, precursor tissue changes indicative of toxicity may …
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