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Genotoxicity assessment of the flavouring agent, perillaldehyde.
Hobbs CA, Taylor SV, Beevers C, Lloyd M, Bowen R, Lillford L, Maronpot R, Hayashi SM. Hobbs CA, et al. Food Chem Toxicol. 2016 Nov;97:232-242. doi: 10.1016/j.fct.2016.08.029. Epub 2016 Sep 1. Food Chem Toxicol. 2016. PMID: 27593899 Free article.
To confirm the safety of flavourings placed on the European Union list of flavourings, perillaldehyde was selected by the European Food Safety Authority as a representative of a subgroup of alicyclic aldehyde flavouring substances to be evaluated for genotoxic poten …
To confirm the safety of flavourings placed on the European Union list of flavourings, perillaldehyde was selected by the European Fo …
Role of pathology peer review in interpretation of the comet assay.
Maronpot RR, Hobbs CA, Hayashi SM. Maronpot RR, et al. J Toxicol Pathol. 2018 Jul;31(3):155-161. doi: 10.1293/tox.2018-0019. Epub 2018 May 11. J Toxicol Pathol. 2018. PMID: 30093784 Free PMC article. Review.
When a comet assay, an increasingly popular in vivo genotoxicity test, shows a positive test result, interpretation of that response requires ruling out any confounding tissue site toxicity. Since the comet assay typically uses only two or three daily doses of test agen
When a comet assay, an increasingly popular in vivo genotoxicity test, shows a positive test result, interpretation of that response …
Occurrence of Perillaldehyde and Other (Suspected) Genotoxic Flavoring Substances in Water-Based Beverages Consumed by Belgian Children.
Dusart A, Van Hoeck E, Goscinny S, Collin S. Dusart A, et al. J Agric Food Chem. 2023 Nov 29;71(47):18538-18545. doi: 10.1021/acs.jafc.3c05381. Epub 2023 Nov 16. J Agric Food Chem. 2023. PMID: 37971765
The method was then applied to 94 samples, including fruit juices, iced teas, lemonades, colas, and sports beverages. Overall, seven different flavoring substances of interest were detected in the samples. Perillaldehyde and furan-2(5H)-one, two genotoxic
The method was then applied to 94 samples, including fruit juices, iced teas, lemonades, colas, and sports beverages. Overall, seven differe …