Gerald Brosch - Search Results

Year	Number of Results
2002	5
2003	3
2004	3
2005	5
2006	3
2007	8
2008	4
2009	2
2010	3
2011	1
2013	1
2014	2
2015	2
2016	1
2018	1
2019	2
2020	2
2021	1
2022	1
2023	0

1

A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation.

Hess L, Moos V, Lauber AA, Reiter W, Schuster M, Hartl N, Lackner D, Boenke T, Koren A, Guzzardo PM, Gundacker B, Riegler A, Vician P, Miccolo C, Leiter S, Chandrasekharan MB, Vcelkova T, Tanzer A, Jun JQ, Bradner J, Brosch G, Hartl M, Bock C, Bürckstümmer T, Kubicek S, Chiocca S, Bhaskara S, Seiser C. Hess L, et al. Among authors: brosch g. PLoS Genet. 2022 Aug 22;18(8):e1010376. doi: 10.1371/journal.pgen.1010376. eCollection 2022 Aug. PLoS Genet. 2022. PMID: 35994477 Free PMC article.

2

Novel Pyridine-Based Hydroxamates and 2'-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activity.

Zwergel C, Di Bello E, Fioravanti R, Conte M, Nebbioso A, Mazzone R, Brosch G, Mercurio C, Varasi M, Altucci L, Valente S, Mai A. Zwergel C, et al. Among authors: brosch g. ChemMedChem. 2021 Mar 18;16(6):989-999. doi: 10.1002/cmdc.202000854. Epub 2020 Dec 16. ChemMedChem. 2021. PMID: 33220015

3

RcLS2F - A Novel Fungal Class 1 KDAC Co-repressor Complex in Aspergillus nidulans.

Bauer I, Gross S, Merschak P, Kremser L, Karahoda B, Bayram ÖS, Abt B, Binder U, Gsaller F, Lindner H, Bayram Ö, Brosch G, Graessle S. Bauer I, et al. Among authors: brosch g. Front Microbiol. 2020 Feb 4;11:43. doi: 10.3389/fmicb.2020.00043. eCollection 2020. Front Microbiol. 2020. PMID: 32117098 Free PMC article.

4

Type I and II PRMTs regulate catabolic as well as detoxifying processes in Aspergillus nidulans.

Bauer I, Lechner L, Pidroni A, Petrone AM, Merschak P, Lindner H, Kremser L, Graessle S, Golderer G, Allipour S, Brosch G. Bauer I, et al. Among authors: brosch g. Fungal Genet Biol. 2019 Aug;129:86-100. doi: 10.1016/j.fgb.2019.05.006. Epub 2019 May 28. Fungal Genet Biol. 2019. PMID: 31145992 Free PMC article.

5

Single-Step Enrichment of a TAP-Tagged Histone Deacetylase of the Filamentous Fungus Aspergillus nidulans for Enzymatic Activity Assay.

Bauer I, Pidroni A, Bayram Ö, Brosch G, Graessle S. Bauer I, et al. Among authors: brosch g. J Vis Exp. 2019 May 1;(147):10.3791/59527. doi: 10.3791/59527. J Vis Exp. 2019. PMID: 31107465 Free PMC article.

6

A Class 1 Histone Deacetylase as Major Regulator of Secondary Metabolite Production in Aspergillus nidulans.

Pidroni A, Faber B, Brosch G, Bauer I, Graessle S. Pidroni A, et al. Among authors: brosch g. Front Microbiol. 2018 Sep 19;9:2212. doi: 10.3389/fmicb.2018.02212. eCollection 2018. Front Microbiol. 2018. PMID: 30283426 Free PMC article.

7

A Class 1 Histone Deacetylase with Potential as an Antifungal Target.

Bauer I, Varadarajan D, Pidroni A, Gross S, Vergeiner S, Faber B, Hermann M, Tribus M, Brosch G, Graessle S. Bauer I, et al. Among authors: brosch g. mBio. 2016 Nov 1;7(6):e00831-16. doi: 10.1128/mBio.00831-16. mBio. 2016. PMID: 27803184 Free PMC article.

8

2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity.

Wang L, Kofler M, Brosch G, Melesina J, Sippl W, Martinez ED, Easmon J. Wang L, et al. Among authors: brosch g. PLoS One. 2015 Dec 23;10(12):e0134556. doi: 10.1371/journal.pone.0134556. eCollection 2015. PLoS One. 2015. PMID: 26698121 Free PMC article.

9

AmcA-a putative mitochondrial ornithine transporter supporting fungal siderophore biosynthesis.

Schafferer L, Beckmann N, Binder U, Brosch G, Haas H. Schafferer L, et al. Among authors: brosch g. Front Microbiol. 2015 Apr 7;6:252. doi: 10.3389/fmicb.2015.00252. eCollection 2015. Front Microbiol. 2015. PMID: 25904899 Free PMC article.

10

1,3,4-Oxadiazole-containing histone deacetylase inhibitors: anticancer activities in cancer cells.

Valente S, Trisciuoglio D, De Luca T, Nebbioso A, Labella D, Lenoci A, Bigogno C, Dondio G, Miceli M, Brosch G, Del Bufalo D, Altucci L, Mai A. Valente S, et al. Among authors: brosch g. J Med Chem. 2014 Jul 24;57(14):6259-65. doi: 10.1021/jm500303u. Epub 2014 Jul 8. J Med Chem. 2014. PMID: 24972008

11

A single allele of Hdac2 but not Hdac1 is sufficient for normal mouse brain development in the absence of its paralog.

Hagelkruys A, Lagger S, Krahmer J, Leopoldi A, Artaker M, Pusch O, Zezula J, Weissmann S, Xie Y, Schöfer C, Schlederer M, Brosch G, Matthias P, Selfridge J, Lassmann H, Knoblich JA, Seiser C. Hagelkruys A, et al. Among authors: brosch g. Development. 2014 Feb;141(3):604-616. doi: 10.1242/dev.100487. Development. 2014. PMID: 24449838 Free PMC article.

12

Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis.

Winter M, Moser MA, Meunier D, Fischer C, Machat G, Mattes K, Lichtenberger BM, Brunmeir R, Weissmann S, Murko C, Humer C, Meischel T, Brosch G, Matthias P, Sibilia M, Seiser C. Winter M, et al. Among authors: brosch g. EMBO J. 2013 Dec 11;32(24):3176-91. doi: 10.1038/emboj.2013.243. Epub 2013 Nov 15. EMBO J. 2013. PMID: 24240174 Free PMC article.

13

Novel cinnamyl hydroxyamides and 2-aminoanilides as histone deacetylase inhibitors: apoptotic induction and cytodifferentiation activity.

Valente S, Tardugno M, Conte M, Cirilli R, Perrone A, Ragno R, Simeoni S, Tramontano A, Massa S, Nebbioso A, Miceli M, Franci G, Brosch G, Altucci L, Mai A. Valente S, et al. Among authors: brosch g. ChemMedChem. 2011 Apr 4;6(4):698-712. doi: 10.1002/cmdc.201000535. Epub 2011 Mar 4. ChemMedChem. 2011. PMID: 21374822

14

Novel insights into the functional role of three protein arginine methyltransferases in Aspergillus nidulans.

Bauer I, Graessle S, Loidl P, Hohenstein K, Brosch G. Bauer I, et al. Among authors: brosch g. Fungal Genet Biol. 2010 Jun;47(6):551-61. doi: 10.1016/j.fgb.2010.03.006. Epub 2010 Mar 23. Fungal Genet Biol. 2010. PMID: 20338257

15

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1).

Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Castellano S, et al. Among authors: brosch g. ChemMedChem. 2010 Mar 1;5(3):398-414. doi: 10.1002/cmdc.200900459. ChemMedChem. 2010. PMID: 20091730

16

A novel motif in fungal class 1 histone deacetylases is essential for growth and development of Aspergillus.

Tribus M, Bauer I, Galehr J, Rieser G, Trojer P, Brosch G, Loidl P, Haas H, Graessle S. Tribus M, et al. Among authors: brosch g. Mol Biol Cell. 2010 Jan 15;21(2):345-53. doi: 10.1091/mbc.e09-08-0750. Epub 2009 Nov 25. Mol Biol Cell. 2010. PMID: 19940017 Free PMC article.

17

New pyrrole-based histone deacetylase inhibitors: binding mode, enzyme- and cell-based investigations.

Mai A, Valente S, Nebbioso A, Simeoni S, Ragno R, Massa S, Brosch G, De Bellis F, Manzo F, Altucci L. Mai A, et al. Among authors: brosch g. Int J Biochem Cell Biol. 2009 Jan;41(1):235-47. doi: 10.1016/j.biocel.2008.09.002. Epub 2008 Sep 12. Int J Biochem Cell Biol. 2009. PMID: 18834955

18

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors.

Mai A, Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, Altucci L. Mai A, et al. Among authors: brosch g. J Med Chem. 2008 Apr 10;51(7):2279-90. doi: 10.1021/jm701595q. Epub 2008 Mar 19. J Med Chem. 2008. PMID: 18348515

19

Histone modifications and chromatin dynamics: a focus on filamentous fungi.

Brosch G, Loidl P, Graessle S. Brosch G, et al. FEMS Microbiol Rev. 2008 May;32(3):409-39. doi: 10.1111/j.1574-6976.2007.00100.x. Epub 2008 Jan 23. FEMS Microbiol Rev. 2008. PMID: 18221488 Free PMC article. Review.

20

Class II-selective histone deacetylase inhibitors. Part 2: alignment-independent GRIND 3-D QSAR, homology and docking studies.

Ragno R, Simeoni S, Rotili D, Caroli A, Botta G, Brosch G, Massa S, Mai A. Ragno R, et al. Among authors: brosch g. Eur J Med Chem. 2008 Mar;43(3):621-32. doi: 10.1016/j.ejmech.2007.05.004. Epub 2007 May 27. Eur J Med Chem. 2008. PMID: 17698257

21

Identification of two new synthetic histone deacetylase inhibitors that modulate globin gene expression in erythroid cells from healthy donors and patients with thalassemia.

Mai A, Jelicic K, Rotili D, Di Noia A, Alfani E, Valente S, Altucci L, Nebbioso A, Massa S, Galanello R, Brosch G, Migliaccio AR, Migliaccio G. Mai A, et al. Among authors: brosch g. Mol Pharmacol. 2007 Nov;72(5):1111-23. doi: 10.1124/mol.107.036772. Epub 2007 Jul 31. Mol Pharmacol. 2007. PMID: 17666592

22

A novel arginine methyltransferase inhibitor with cellular activity.

Spannhoff A, Machmur R, Heinke R, Trojer P, Bauer I, Brosch G, Schüle R, Hanefeld W, Sippl W, Jung M. Spannhoff A, et al. Among authors: brosch g. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4150-3. doi: 10.1016/j.bmcl.2007.05.088. Epub 2007 Jun 3. Bioorg Med Chem Lett. 2007. PMID: 17570663

23

Novel pyrrole-containing histone deacetylase inhibitors endowed with cytodifferentiation activity.

Mai A, Valente S, Rotili D, Massa S, Botta G, Brosch G, Miceli M, Nebbioso A, Altucci L. Mai A, et al. Among authors: brosch g. Int J Biochem Cell Biol. 2007;39(7-8):1510-22. doi: 10.1016/j.biocel.2007.03.020. Epub 2007 Apr 4. Int J Biochem Cell Biol. 2007. PMID: 17482499

24

Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors.

Mai A, Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT. Mai A, et al. Among authors: brosch g. ChemMedChem. 2007 Jul;2(7):987-91. doi: 10.1002/cmdc.200700023. ChemMedChem. 2007. PMID: 17458842 No abstract available.

25

Target-based approach to inhibitors of histone arginine methyltransferases.

Spannhoff A, Heinke R, Bauer I, Trojer P, Metzger E, Gust R, Schüle R, Brosch G, Sippl W, Jung M. Spannhoff A, et al. Among authors: brosch g. J Med Chem. 2007 May 17;50(10):2319-25. doi: 10.1021/jm061250e. Epub 2007 Apr 14. J Med Chem. 2007. PMID: 17432842

26

Small molecule inhibitors of histone arginine methyltransferases: homology modeling, molecular docking, binding mode analysis, and biological evaluations.

Ragno R, Simeoni S, Castellano S, Vicidomini C, Mai A, Caroli A, Tramontano A, Bonaccini C, Trojer P, Bauer I, Brosch G, Sbardella G. Ragno R, et al. Among authors: brosch g. J Med Chem. 2007 Mar 22;50(6):1241-53. doi: 10.1021/jm061213n. Epub 2007 Feb 27. J Med Chem. 2007. PMID: 17323938

27

Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.

Mai A, Rotili D, Massa S, Brosch G, Simonetti G, Passariello C, Palamara AT. Mai A, et al. Among authors: brosch g. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1221-5. doi: 10.1016/j.bmcl.2006.12.028. Epub 2006 Dec 12. Bioorg Med Chem Lett. 2007. PMID: 17196388

28

Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.

Mai A, Massa S, Rotili D, Simeoni S, Ragno R, Botta G, Nebbioso A, Miceli M, Altucci L, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2006 Oct 5;49(20):6046-56. doi: 10.1021/jm0605536. J Med Chem. 2006. PMID: 17004718

29

Aroyl-pyrrolyl hydroxyamides: influence of pyrrole C4-phenylacetyl substitution on histone deacetylase inhibition.

Mai A, Massa S, Valente S, Simeoni S, Ragno R, Bottoni P, Scatena R, Brosch G. Mai A, et al. Among authors: brosch g. ChemMedChem. 2006 Feb;1(2):225-37. doi: 10.1002/cmdc.200500015. ChemMedChem. 2006. PMID: 16892355

30

HdaA, a major class 2 histone deacetylase of Aspergillus nidulans, affects growth under conditions of oxidative stress.

Tribus M, Galehr J, Trojer P, Brosch G, Loidl P, Marx F, Haas H, Graessle S. Tribus M, et al. Among authors: brosch g. Eukaryot Cell. 2005 Oct;4(10):1736-45. doi: 10.1128/EC.4.10.1736-1745.2005. Eukaryot Cell. 2005. PMID: 16215180 Free PMC article.

31

TIS7 regulation of the beta-catenin/Tcf-4 target gene osteopontin (OPN) is histone deacetylase-dependent.

Vietor I, Kurzbauer R, Brosch G, Huber LA. Vietor I, et al. Among authors: brosch g. J Biol Chem. 2005 Dec 2;280(48):39795-801. doi: 10.1074/jbc.M509836200. Epub 2005 Oct 3. J Biol Chem. 2005. PMID: 16204248 Free article.

32

Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates.

Mai A, Massa S, Rotili D, Pezzi R, Bottoni P, Scatena R, Meraner J, Brosch G. Mai A, et al. Among authors: brosch g. Bioorg Med Chem Lett. 2005 Nov 1;15(21):4656-61. doi: 10.1016/j.bmcl.2005.07.081. Bioorg Med Chem Lett. 2005. PMID: 16165353

33

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.

Mai A, Massa S, Pezzi R, Simeoni S, Rotili D, Nebbioso A, Scognamiglio A, Altucci L, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2005 May 5;48(9):3344-53. doi: 10.1021/jm049002a. J Med Chem. 2005. PMID: 15857140

34

Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas.

Vance KW, Carreira S, Brosch G, Goding CR. Vance KW, et al. Among authors: brosch g. Cancer Res. 2005 Mar 15;65(6):2260-8. doi: 10.1158/0008-5472.CAN-04-3045. Cancer Res. 2005. PMID: 15781639 Free article.

35

Histone methyltransferases in Aspergillus nidulans: evidence for a novel enzyme with a unique substrate specificity.

Trojer P, Dangl M, Bauer I, Graessle S, Loidl P, Brosch G. Trojer P, et al. Among authors: brosch g. Biochemistry. 2004 Aug 24;43(33):10834-43. doi: 10.1021/bi049626i. Biochemistry. 2004. PMID: 15311944

36

3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.

Ragno R, Mai A, Massa S, Cerbara I, Valente S, Bottoni P, Scatena R, Jesacher F, Loidl P, Brosch G. Ragno R, et al. Among authors: brosch g. J Med Chem. 2004 Mar 11;47(6):1351-9. doi: 10.1021/jm031036f. J Med Chem. 2004. PMID: 14998325

37

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.

Mai A, Massa S, Cerbara I, Valente S, Ragno R, Bottoni P, Scatena R, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2004 Feb 26;47(5):1098-109. doi: 10.1021/jm030990+. J Med Chem. 2004. PMID: 14971890

38

Discovery of (aryloxopropenyl)pyrrolyl hydroxyamides as selective inhibitors of class IIa histone deacetylase homologue HD1-A.

Mai A, Massa S, Pezzi R, Rotili D, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2003 Nov 6;46(23):4826-9. doi: 10.1021/jm034167p. J Med Chem. 2003. PMID: 14584932

39

Histone deacetylases in fungi: novel members, new facts.

Trojer P, Brandtner EM, Brosch G, Loidl P, Galehr J, Linzmaier R, Haas H, Mair K, Tribus M, Graessle S. Trojer P, et al. Among authors: brosch g. Nucleic Acids Res. 2003 Jul 15;31(14):3971-81. doi: 10.1093/nar/gkg473. Nucleic Acids Res. 2003. PMID: 12853613 Free PMC article.

40

3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-alkylamides as a new class of synthetic histone deacetylase inhibitors. 1. Design, synthesis, biological evaluation, and binding mode studies performed through three different docking procedures.

Mai A, Massa S, Ragno R, Cerbara I, Jesacher F, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2003 Feb 13;46(4):512-24. doi: 10.1021/jm021070e. J Med Chem. 2003. PMID: 12570373

41

Characterization of inhibitor-resistant histone deacetylase activity in plant-pathogenic fungi.

Baidyaroy D, Brosch G, Graessle S, Trojer P, Walton JD. Baidyaroy D, et al. Among authors: brosch g. Eukaryot Cell. 2002 Aug;1(4):538-47. doi: 10.1128/EC.1.4.538-547.2002. Eukaryot Cell. 2002. PMID: 12456002 Free PMC article.

42

TIS7 interacts with the mammalian SIN3 histone deacetylase complex in epithelial cells.

Vietor I, Vadivelu SK, Wick N, Hoffman R, Cotten M, Seiser C, Fialka I, Wunderlich W, Haase A, Korinkova G, Brosch G, Huber LA. Vietor I, et al. Among authors: brosch g. EMBO J. 2002 Sep 2;21(17):4621-31. doi: 10.1093/emboj/cdf461. EMBO J. 2002. PMID: 12198164 Free PMC article.

43

Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.

Wittich S, Scherf H, Xie C, Brosch G, Loidl P, Gerhäuser C, Jung M. Wittich S, et al. Among authors: brosch g. J Med Chem. 2002 Jul 18;45(15):3296-309. doi: 10.1021/jm0208119. J Med Chem. 2002. PMID: 12109913

44

Binding mode analysis of 3-(4-benzoyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide: a new synthetic histone deacetylase inhibitor inducing histone hyperacetylation, growth inhibition, and terminal cell differentiation.

Mai A, Massa S, Ragno R, Esposito M, Sbardella G, Nocca G, Scatena R, Jesacher F, Loidl P, Brosch G. Mai A, et al. Among authors: brosch g. J Med Chem. 2002 Apr 25;45(9):1778-84. doi: 10.1021/jm011088+. J Med Chem. 2002. PMID: 11960489

45

Histone deacetylase 1 inactivation by an adenovirus early gene product.

Chiocca S, Kurtev V, Colombo R, Boggio R, Sciurpi MT, Brosch G, Seiser C, Draetta GF, Cotten M. Chiocca S, et al. Among authors: brosch g. Curr Biol. 2002 Apr 2;12(7):594-8. doi: 10.1016/s0960-9822(02)00720-0. Curr Biol. 2002. PMID: 11937030 Free article.

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