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Recombinant Treponema pallidum antigens in syphilis serology.
Gerber A, Krell S, Morenz J. Gerber A, et al. Immunobiology. 1996-1997;196(5):535-49. doi: 10.1016/s0171-2985(97)80070-8. Immunobiology. 1996. PMID: 9145331
Treponema pallidum, the etiological agent of syphilis, is characterized by a paucity of surface exposed outer membrane proteins and a high content of cytoplasma membrane associated lipoproteins. ...Assays with the three antigens combined resulted in a further …
Treponema pallidum, the etiological agent of syphilis, is characterized by a paucity of surface exposed outer membrane proteins and …
Cathepsin K expression in human lung.
Bühling F, Waldburg N, Gerber A, Häckel C, Krüger S, Reinhold D, Brömme D, Weber E, Ansorge S, Welte T. Bühling F, et al. Adv Exp Med Biol. 2000;477:281-6. doi: 10.1007/0-306-46826-3_30. Adv Exp Med Biol. 2000. PMID: 10849755
These data could be confirmed at mRNA level using a quantitative RT-PCR as well as by visualisation of the specific enzymatic activity in epithelial cell lines. ...
These data could be confirmed at mRNA level using a quantitative RT-PCR as well as by visualisation of the specific enzymatic activit …
Interleukin-6 and transforming growth factor-beta 1 control expression of cathepsins B and L in human lung epithelial cells.
Gerber A, Wille A, Welte T, Ansorge S, Bühling F. Gerber A, et al. J Interferon Cytokine Res. 2001 Jan;21(1):11-9. doi: 10.1089/107999001459114. J Interferon Cytokine Res. 2001. PMID: 11177576
Cathepsins B and L are commonly expressed cysteine proteinases that play a major role in lysosomal bulk proteolysis, protein processing, matrix degradation, and tissue remodeling. ...Investigations were performed using the human lung epithelial cell line A-549. IL-6 …
Cathepsins B and L are commonly expressed cysteine proteinases that play a major role in lysosomal bulk proteolysis, protein processi …
Effect of granulocyte colony-stimulating factor treatment on ex vivo neutrophil functions in nonneutropenic surgical intensive care patients.
Gerber A, Struy H, Weiss G, Lippert H, Ansorge S, Schulz HU. Gerber A, et al. J Interferon Cytokine Res. 2000 Dec;20(12):1083-90. doi: 10.1089/107999000750053753. J Interferon Cytokine Res. 2000. PMID: 11152575
G-CSF application resulted in a 3.5-fold increase in peripheral blood granulocyte count at day 5 of treatment. The mean plasma G-CSF level rose from 48 to a maximum of 2314 pg/ml at day 1 of G-CSF therapy. ...Thus, G-CSF may be a useful adjuvant treatment for …
G-CSF application resulted in a 3.5-fold increase in peripheral blood granulocyte count at day 5 of treatment. The mean plasma G-CSF …
Expression of cathepsins B and L in human lung epithelial cells is regulated by cytokines.
Gerber A, Welte T, Ansorge S, Bühling F. Gerber A, et al. Adv Exp Med Biol. 2000;477:287-92. doi: 10.1007/0-306-46826-3_31. Adv Exp Med Biol. 2000. PMID: 10849756
The aim of this study was to investigate the effect of IL-1 beta, IL-6, IL-10, TGF-beta 1, and HGF on mRNA expression and protein level in human lung epithelial cell lines A-549 and BEAS-2B. IL-6 leads to a twofold increase in cathepsin L mRNA expression, whereas TG …
The aim of this study was to investigate the effect of IL-1 beta, IL-6, IL-10, TGF-beta 1, and HGF on mRNA expression and protein level in h …
Regulation of in vitro and in vivo immune functions by the cytosolic adaptor protein SKAP-HOM.
Togni M, Swanson KD, Reimann S, Kliche S, Pearce AC, Simeoni L, Reinhold D, Wienands J, Neel BG, Schraven B, Gerber A. Togni M, et al. Mol Cell Biol. 2005 Sep;25(18):8052-63. doi: 10.1128/MCB.25.18.8052-8063.2005. Mol Cell Biol. 2005. PMID: 16135797 Free PMC article.
SKAP-HOM is a cytosolic adaptor protein representing a specific substrate for the Src family protein tyrosine kinase Fyn. Previously, several groups have provided experimental evidence that SKAP-HOM (most likely in cooperation with the cytosolic adaptor protein ADAP …
SKAP-HOM is a cytosolic adaptor protein representing a specific substrate for the Src family protein tyrosine kinase Fyn. Prev …
TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
Preller V, Gerber A, Wrenger S, Togni M, Marguet D, Tadje J, Lendeckel U, Röcken C, Faust J, Neubert K, Schraven B, Martin R, Ansorge S, Brocke S, Reinhold D. Preller V, et al. J Immunol. 2007 Apr 1;178(7):4632-40. doi: 10.4049/jimmunol.178.7.4632. J Immunol. 2007. PMID: 17372022
In contrast to the reduction in TGF-beta1 production, responsiveness to external TGF-beta1 was normal in T cells from CD26(-/-) mice, excluding alterations in TGF-beta1 sensitivity as a mechanism causing the loss of immune regulation. ...These results identify CD26/DP IV a …
In contrast to the reduction in TGF-beta1 production, responsiveness to external TGF-beta1 was normal in T cells from CD26(-/-) mice, exclud …
Cathepsin K--a marker of macrophage differentiation?
Bühling F, Reisenauer A, Gerber A, Krüger S, Weber E, Brömme D, Roessner A, Ansorge S, Welte T, Röcken C. Bühling F, et al. J Pathol. 2001 Oct;195(3):375-82. doi: 10.1002/path.959. J Pathol. 2001. PMID: 11673837
Cathepsin K is a cysteine protease with high matrix-degrading activity. Initially, cathepsin K was described as being expressed exclusively by osteoclasts. It was suggested that cathepsin K expression is a specific feature of cells involved in bone remodelling. The …
Cathepsin K is a cysteine protease with high matrix-degrading activity. Initially, cathepsin K was described as being expressed exclu …
Protection against UVA damage and effects on neutrophil-derived reactive oxygen species by beta-carotene.
Bohne M, Struy H, Gerber A, Gollnick H. Bohne M, et al. Inflamm Res. 1997 Oct;46(10):425-6. doi: 10.1007/s000110050217. Inflamm Res. 1997. PMID: 9410478
Further, in a controlled study, we were able to demonstrate an in vivo protective effect of beta-carotene on neutrophils against UVA damage by beta-carotene supplemented subjects....
Further, in a controlled study, we were able to demonstrate an in vivo protective effect of beta-carotene on neutrophils against UVA …
[Cathepsin cysteine proteinases in the lung].
Bühling F, Gerber A, Ansorge S, Welte T. Bühling F, et al. Pneumologie. 1999 Aug;53(8):400-7. Pneumologie. 1999. PMID: 10483279 Review. German.
Since the first reports showed an emphysema induction in rats after intratracheal application of the cysteine protease papain, a number of proteolytic enzymes involved in the remodeling of the extracellular matrix of the lung were discovered. ...
Since the first reports showed an emphysema induction in rats after intratracheal application of the cysteine protease papain, a numb …
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