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The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family.
Gotfredsen M, Gerdes K. Gotfredsen M, et al. Among authors: gerdes k. Mol Microbiol. 1998 Aug;29(4):1065-76. doi: 10.1046/j.1365-2958.1998.00993.x. Mol Microbiol. 1998. PMID: 9767574
Here, we show that the relBE genes of Escherichia coli K-12 have all the basic features previously connected with toxin-antitoxin systems: (i) relE encodes a cytotoxin lethal or inhibitory to host cells; (ii) relB encodes an antitoxin that prevents the lethal action of the …
Here, we show that the relBE genes of Escherichia coli K-12 have all the basic features previously connected with toxin-antitoxin sys …
Mechanism of post-segregational killing by the hok/sok system of plasmid R1. Sok antisense RNA regulates hok gene expression indirectly through the overlapping mok gene.
Thisted T, Gerdes K. Thisted T, et al. Among authors: gerdes k. J Mol Biol. 1992 Jan 5;223(1):41-54. doi: 10.1016/0022-2836(92)90714-u. J Mol Biol. 1992. PMID: 1370544
Mechanism of killer gene activation. Antisense RNA-dependent RNase III cleavage ensures rapid turn-over of the stable hok, srnB and pndA effector messenger RNAs.
Gerdes K, Nielsen A, Thorsted P, Wagner EG. Gerdes K, et al. J Mol Biol. 1992 Aug 5;226(3):637-49. doi: 10.1016/0022-2836(92)90621-p. J Mol Biol. 1992. PMID: 1380562
Mechanism of post-segregational killing by the hok/sok system of plasmid R1: sok antisense RNA regulates formation of a hok mRNA species correlated with killing of plasmid-free cells.
Gerdes K, Thisted T, Martinussen J. Gerdes K, et al. Mol Microbiol. 1990 Nov;4(11):1807-18. doi: 10.1111/j.1365-2958.1990.tb02029.x. Mol Microbiol. 1990. PMID: 1707122
The rifampicin-inducible genes srnB from F and pnd from R483 are regulated by antisense RNAs and mediate plasmid maintenance by killing of plasmid-free segregants.
Nielsen AK, Thorsted P, Thisted T, Wagner EG, Gerdes K. Nielsen AK, et al. Among authors: gerdes k. Mol Microbiol. 1991 Aug;5(8):1961-73. doi: 10.1111/j.1365-2958.1991.tb00818.x. Mol Microbiol. 1991. PMID: 1722558
The kis and kid genes of the parD maintenance system of plasmid R1 form an operon that is autoregulated at the level of transcription by the co-ordinated action of the Kis and Kid proteins.
Ruiz-Echevarría MJ, Berzal-Herranz A, Gerdes K, Díaz-Orejas R. Ruiz-Echevarría MJ, et al. Among authors: gerdes k. Mol Microbiol. 1991 Nov;5(11):2685-93. doi: 10.1111/j.1365-2958.1991.tb01977.x. Mol Microbiol. 1991. PMID: 1779758
The hok killer gene family in gram-negative bacteria.
Gerdes K, Poulsen LK, Thisted T, Nielsen AK, Martinussen J, Andreasen PH. Gerdes K, et al. New Biol. 1990 Nov;2(11):946-56. New Biol. 1990. PMID: 2101633 Review.
Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.
Gerdes K, Helin K, Christensen OW, Løbner-Olesen A. Gerdes K, et al. J Mol Biol. 1988 Sep 5;203(1):119-29. doi: 10.1016/0022-2836(88)90096-4. J Mol Biol. 1988. PMID: 2460630
Partitioning of plasmid R1. Structural and functional analysis of the parA locus.
Gerdes K, Molin S. Gerdes K, et al. J Mol Biol. 1986 Aug 5;190(3):269-79. doi: 10.1016/0022-2836(86)90001-x. J Mol Biol. 1986. PMID: 3023637
Effects of genes exerting growth inhibition and plasmid stability on plasmid maintenance.
Boe L, Gerdes K, Molin S. Boe L, et al. Among authors: gerdes k. J Bacteriol. 1987 Oct;169(10):4646-50. doi: 10.1128/jb.169.10.4646-4650.1987. J Bacteriol. 1987. PMID: 3308847 Free PMC article.
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