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Angiogenesis: a team effort coordinated by notch.
Phng LK, Gerhardt H. Phng LK, et al. Dev Cell. 2009 Feb;16(2):196-208. doi: 10.1016/j.devcel.2009.01.015. Dev Cell. 2009. PMID: 19217422 Review.
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.
Ruhrberg C, Gerhardt H, Golding M, Watson R, Ioannidou S, Fujisawa H, Betsholtz C, Shima DT. Ruhrberg C, et al. Genes Dev. 2002 Oct 15;16(20):2684-98. doi: 10.1101/gad.242002. Genes Dev. 2002. PMID: 12381667 Free PMC article.
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C, Alitalo K, Shima D, Betsholtz C. Gerhardt H, et al. J Cell Biol. 2003 Jun 23;161(6):1163-77. doi: 10.1083/jcb.200302047. Epub 2003 Jun 16. J Cell Biol. 2003. PMID: 12810700 Free PMC article.
Endothelial-pericyte interactions in angiogenesis.
Gerhardt H, Betsholtz C. Gerhardt H, et al. Cell Tissue Res. 2003 Oct;314(1):15-23. doi: 10.1007/s00441-003-0745-x. Epub 2003 Jul 22. Cell Tissue Res. 2003. PMID: 12883993 Review.
How do endothelial cells orientate?
Gerhardt H, Betsholtz C. Gerhardt H, et al. EXS. 2005;(94):3-15. doi: 10.1007/3-7643-7311-3_1. EXS. 2005. PMID: 15617467 Review.
Pericytes: gatekeepers in tumour cell metastasis?
Gerhardt H, Semb H. Gerhardt H, et al. J Mol Med (Berl). 2008 Feb;86(2):135-44. doi: 10.1007/s00109-007-0258-2. Epub 2007 Sep 22. J Mol Med (Berl). 2008. PMID: 17891366 Review.
Therapeutic antibodies targeting angiomotin inhibit angiogenesis in vivo.
Levchenko T, Veitonmäki N, Lundkvist A, Gerhardt H, Ming Y, Berggren K, Kvanta A, Carlsson R, Holmgren L. Levchenko T, et al. FASEB J. 2008 Mar;22(3):880-9. doi: 10.1096/fj.07-9509com. Epub 2007 Nov 5. FASEB J. 2008. PMID: 17984175
Growth factor gradients in vascular patterning.
Lundkvist A, Lee S, Iruela-Arispe L, Betsholtz C, Gerhardt H. Lundkvist A, et al. Novartis Found Symp. 2007;283:194-201; discussion 201-6, 238-41. doi: 10.1002/9780470319413.ch15. Novartis Found Symp. 2007. PMID: 18300423
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.
Graupera M, Guillermet-Guibert J, Foukas LC, Phng LK, Cain RJ, Salpekar A, Pearce W, Meek S, Millan J, Cutillas PR, Smith AJ, Ridley AJ, Ruhrberg C, Gerhardt H, Vanhaesebroeck B. Graupera M, et al. Nature. 2008 May 29;453(7195):662-6. doi: 10.1038/nature06892. Epub 2008 Apr 30. Nature. 2008. PMID: 18449193
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