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Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells.
Goc J, Germain C, Vo-Bourgais TK, Lupo A, Klein C, Knockaert S, de Chaisemartin L, Ouakrim H, Becht E, Alifano M, Validire P, Remark R, Hammond SA, Cremer I, Damotte D, Fridman WH, Sautès-Fridman C, Dieu-Nosjean MC. Goc J, et al. Among authors: germain c. Cancer Res. 2014 Feb 1;74(3):705-15. doi: 10.1158/0008-5472.CAN-13-1342. Epub 2013 Dec 23. Cancer Res. 2014. PMID: 24366885
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer.
Germain C, Gnjatic S, Tamzalit F, Knockaert S, Remark R, Goc J, Lepelley A, Becht E, Katsahian S, Bizouard G, Validire P, Damotte D, Alifano M, Magdeleinat P, Cremer I, Teillaud JL, Fridman WH, Sautès-Fridman C, Dieu-Nosjean MC. Germain C, et al. Am J Respir Crit Care Med. 2014 Apr 1;189(7):832-44. doi: 10.1164/rccm.201309-1611OC. Am J Respir Crit Care Med. 2014. PMID: 24484236
Shaping of an effective immune microenvironment to and by cancer cells.
Becht E, Goc J, Germain C, Giraldo NA, Dieu-Nosjean MC, Sautès-Fridman C, Fridman WH. Becht E, et al. Among authors: germain c. Cancer Immunol Immunother. 2014 Oct;63(10):991-7. doi: 10.1007/s00262-014-1590-3. Epub 2014 Aug 12. Cancer Immunol Immunother. 2014. PMID: 25112529 Review.
A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4+ T cell receptor repertoire clonality.
Zhu W, Germain C, Liu Z, Sebastian Y, Devi P, Knockaert S, Brohawn P, Lehmann K, Damotte D, Validire P, Yao Y, Valge-Archer V, Hammond SA, Dieu-Nosjean MC, Higgs BW. Zhu W, et al. Among authors: germain c. Oncoimmunology. 2015 Jun 1;4(12):e1051922. doi: 10.1080/2162402X.2015.1051922. eCollection 2015 Dec. Oncoimmunology. 2015. PMID: 26587322 Free PMC article.
Calreticulin Expression in Human Non-Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis.
Fucikova J, Becht E, Iribarren K, Goc J, Remark R, Damotte D, Alifano M, Devi P, Biton J, Germain C, Lupo A, Fridman WH, Dieu-Nosjean MC, Kroemer G, Sautès-Fridman C, Cremer I. Fucikova J, et al. Among authors: germain c. Cancer Res. 2016 Apr 1;76(7):1746-56. doi: 10.1158/0008-5472.CAN-15-1142. Epub 2016 Feb 3. Cancer Res. 2016. PMID: 26842877
Intratumoral Immune Cell Densities Are Associated with Lung Adenocarcinoma Gene Alterations.
Mansuet-Lupo A, Alifano M, Pécuchet N, Biton J, Becht E, Goc J, Germain C, Ouakrim H, Régnard JF, Cremer I, Laurent-Puig P, Dieu-Nosjean MC, Blons H, Damotte D. Mansuet-Lupo A, et al. Among authors: germain c. Am J Respir Crit Care Med. 2016 Dec 1;194(11):1403-1412. doi: 10.1164/rccm.201510-2031OC. Am J Respir Crit Care Med. 2016. PMID: 27299180
161 results