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Differential expression of the F-box proteins Skp2 and Skp2B in breast cancer.
Radke S, Pirkmaier A, Germain D. Radke S, et al. Among authors: germain d. Oncogene. 2005 May 12;24(21):3448-58. doi: 10.1038/sj.onc.1208328. Oncogene. 2005. PMID: 15782142
Cyclin D1 and D3 associate with the SCF complex and are coordinately elevated in breast cancer.
Russell A, Thompson MA, Hendley J, Trute L, Armes J, Germain D. Russell A, et al. Among authors: germain d. Oncogene. 1999 Mar 18;18(11):1983-91. doi: 10.1038/sj.onc.1202511. Oncogene. 1999. PMID: 10208420
Inhibitory effect of p21 in MCF-7 cells is overcome by its coordinated stabilization with D-type cyclins.
Russell A, Hendley J, Germain D. Russell A, et al. Among authors: germain d. Oncogene. 1999 Nov 11;18(47):6454-9. doi: 10.1038/sj.onc.1203030. Oncogene. 1999. PMID: 10597247
A splice variant of Skp2 is retained in the cytoplasm and fails to direct cyclin D1 ubiquitination in the uterine cancer cell line SK-UT.
Ganiatsas S, Dow R, Thompson A, Schulman B, Germain D. Ganiatsas S, et al. Among authors: germain d. Oncogene. 2001 Jun 21;20(28):3641-50. doi: 10.1038/sj.onc.1204501. Oncogene. 2001. PMID: 11439327
Retinoic acid-mediated growth arrest requires ubiquitylation and degradation of the F-box protein Skp2.
Dow R, Hendley J, Pirkmaier A, Musgrove EA, Germain D. Dow R, et al. Among authors: germain d. J Biol Chem. 2001 Dec 7;276(49):45945-51. doi: 10.1074/jbc.M103593200. Epub 2001 Oct 10. J Biol Chem. 2001. PMID: 11595732
Cyclin d1 overexpression sensitizes breast cancer cells to fenretinide.
Pirkmaier A, Yuen K, Hendley J, O'Connell MJ, Germain D. Pirkmaier A, et al. Among authors: germain d. Clin Cancer Res. 2003 May;9(5):1877-84. Clin Cancer Res. 2003. PMID: 12738746
Alternative mammary oncogenic pathways are induced by D-type cyclins; MMTV-cyclin D3 transgenic mice develop squamous cell carcinoma.
Pirkmaier A, Dow R, Ganiatsas S, Waring P, Warren K, Thompson A, Hendley J, Germain D. Pirkmaier A, et al. Among authors: germain d. Oncogene. 2003 Jul 10;22(28):4425-33. doi: 10.1038/sj.onc.1206488. Oncogene. 2003. PMID: 12853979
Cyclin-dependent kinase inhibition by the KLF6 tumor suppressor protein through interaction with cyclin D1.
Benzeno S, Narla G, Allina J, Cheng GZ, Reeves HL, Banck MS, Odin JA, Diehl JA, Germain D, Friedman SL. Benzeno S, et al. Among authors: germain d. Cancer Res. 2004 Jun 1;64(11):3885-91. doi: 10.1158/0008-5472.CAN-03-2818. Cancer Res. 2004. PMID: 15172998
Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.
Ishii Y, Pirkmaier A, Alvarez JV, Frank DA, Keselman I, Logothetis D, Mandeli J, O'Connell MJ, Waxman S, Germain D. Ishii Y, et al. Among authors: germain d. J Natl Cancer Inst. 2006 Sep 6;98(17):1238-47. doi: 10.1093/jnci/djj334. J Natl Cancer Inst. 2006. PMID: 16954476
Skp2B stimulates mammary gland development by inhibiting REA, the repressor of the estrogen receptor.
Umanskaya K, Radke S, Chander H, Monardo R, Xu X, Pan ZQ, O'Connell MJ, Germain D. Umanskaya K, et al. Among authors: germain d. Mol Cell Biol. 2007 Nov;27(21):7615-22. doi: 10.1128/MCB.01239-07. Epub 2007 Sep 4. Mol Cell Biol. 2007. PMID: 17785450 Free PMC article.
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