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Germline investigation in male breast cancer of DNA repair genes by next-generation sequencing.
Scarpitta R, Zanna I, Aretini P, Gambino G, Scatena C, Mei B, Ghilli M, Rossetti E, Roncella M, Congregati C, Bonci F, Naccarato AG, Palli D, Caligo MA. Scarpitta R, et al. Breast Cancer Res Treat. 2019 Dec;178(3):557-564. doi: 10.1007/s10549-019-05429-z. Epub 2019 Sep 11. Breast Cancer Res Treat. 2019. PMID: 31512090
PURPOSE: In order to better define the breast cancer (BC) genetic risk factors in men, a germline investigation was carried out on 81 Male BC cases by screening the 24 genes involved in BC predisposition, genome stability maintenance and …
PURPOSE: In order to better define the breast cancer (BC) genetic risk factors in men, a germline investigation …
Identification and Characterization of an Exonic Duplication in PALB2 in a Man with Synchronous Breast and Prostate Cancer.
Bouras A, Lafaye C, Leone M, Kherraf ZE, Martin-Denavit T, Fert-Ferrer S, Calender A, Boutry-Kryza N. Bouras A, et al. Int J Mol Sci. 2022 Jan 8;23(2):667. doi: 10.3390/ijms23020667. Int J Mol Sci. 2022. PMID: 35054852 Free PMC article.
PALB2 (partner and localizer of BRCA2), as indicated by its name, is a BRCA2-interacting protein that plays an important role in homologous recombination (HR) and DNA double-strand break (DSB) repair. While pathogenic variants of PALB2 have been well proven to confe …
PALB2 (partner and localizer of BRCA2), as indicated by its name, is a BRCA2-interacting protein that plays an important role in homologous …
Characteristics of Germline Non-BRCA Mutation Status of High-Risk Breast Cancer Patients in China and Correlation with High-Risk Factors and Multigene Testing Suggestions.
Su Y, Yao Q, Xu Y, Yu C, Zhang J, Wang Q, Li J, Shi D, Yu B, Zeng Y, Zhu X, Bai Q, Zhou X. Su Y, et al. Front Genet. 2021 Nov 30;12:674094. doi: 10.3389/fgene.2021.674094. eCollection 2021. Front Genet. 2021. PMID: 34917121 Free PMC article.
Methods: A total of 230 high-risk breast cancer patients from Fudan University Shanghai Cancer Center who had undergone peripheral blood germline 72 genes next-generation sequencing (NGS) from June 2018 to June 2020 were enr …
Methods: A total of 230 high-risk breast cancer patients from Fudan University Shanghai Cancer Center who had undergone …