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Germline prediction of immune checkpoint inhibitor discontinuation for immune-related adverse events.
Middha P, Thummalapalli R, Quandt Z, Balaratnam K, Cardenas E, Falcon CJ; Princess Margaret Lung Group; Gubens MA, Huntsman S, Khan K, Li M, Lovly CM, Patel D, Zhan LJ, Liu G, Aldrich MC, Schoenfeld AJ, Ziv E. Middha P, et al. medRxiv [Preprint]. 2024 Jun 11:2024.06.10.24308518. doi: 10.1101/2024.06.10.24308518. medRxiv. 2024. PMID: 38947092 Free PMC article. Preprint.
INTRODUCTION: Immune checkpoint inhibitors (ICIs) can yield remarkable clinical responses in subsets of patients with solid tumors but can also often lead to immune-related adverse events (irAEs). ...Using data from 1,327 patients …
INTRODUCTION: Immune checkpoint inhibitors (ICIs) can yield remarkable clinical responses in subsets of patients with s …
Biomarkers for immune-related adverse events in cancer patients treated with immune checkpoint inhibitors.
Liang Y, Maeda O, Ando Y. Liang Y, et al. Jpn J Clin Oncol. 2024 Apr 6;54(4):365-375. doi: 10.1093/jjco/hyad184. Jpn J Clin Oncol. 2024. PMID: 38183211
Although immune checkpoint inhibitors have greatly improved cancer therapy, they also cause immune-related adverse events, including a wide range of inflammatory side effects resulting from excessive immune activation. ...Fu …
Although immune checkpoint inhibitors have greatly improved cancer therapy, they also cause immune-related