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Dihydrodipicolinate synthase is not inhibited by its substrate, (S)-aspartate beta-semialdehyde.
Dobson RC, Gerrard JA, Pearce FG. Dobson RC, et al. Among authors: gerrard ja. Biochem J. 2004 Feb 1;377(Pt 3):757-62. doi: 10.1042/BJ20031389. Biochem J. 2004. PMID: 14580236 Free PMC article.
Ascorbic acid-based inhibitors of alpha-amylases.
Abell AD, Ratcliffe MJ, Gerrard J. Abell AD, et al. Bioorg Med Chem Lett. 1998 Jul 7;8(13):1703-6. doi: 10.1016/s0960-894x(98)00298-4. Bioorg Med Chem Lett. 1998. PMID: 9873419
Kinetic characterisation of ene-diol-based inhibitors of alpha-amylase.
Gerrard JA, Prince MJ, Abell AD. Gerrard JA, et al. Bioorg Med Chem Lett. 2000 Jul 17;10(14):1575-6. doi: 10.1016/s0960-894x(00)00288-2. Bioorg Med Chem Lett. 2000. PMID: 10915054
Metabolic databases - what next?
Gerrard JA, Sparrow AD, Wells JA. Gerrard JA, et al. Trends Biochem Sci. 2001 Feb;26(2):137-40. doi: 10.1016/s0968-0004(00)01759-x. Trends Biochem Sci. 2001. PMID: 11166573 No abstract available.
The preparation of (S)-aspartate semi-aldehyde appropriate for use in biochemical studies.
Roberts SJ, Morris JC, Dobson RC, Gerrard JA. Roberts SJ, et al. Among authors: gerrard ja. Bioorg Med Chem Lett. 2003 Jan 20;13(2):265-7. doi: 10.1016/s0960-894x(02)00923-x. Bioorg Med Chem Lett. 2003. PMID: 12482436
The crystal structure of three site-directed mutants of Escherichia coli dihydrodipicolinate synthase: further evidence for a catalytic triad.
Dobson RC, ValegÄrd K, Gerrard JA. Dobson RC, et al. Among authors: gerrard ja. J Mol Biol. 2004 Apr 23;338(2):329-39. doi: 10.1016/j.jmb.2004.02.060. J Mol Biol. 2004. PMID: 15066435
Dihydrodipicolinate synthase (DHDPS) from Escherichia coli displays partial mixed inhibition with respect to its first substrate, pyruvate.
Dobson RC, Griffin MD, Roberts SJ, Gerrard JA. Dobson RC, et al. Among authors: gerrard ja. Biochimie. 2004 Apr-May;86(4-5):311-5. doi: 10.1016/j.biochi.2004.03.008. Biochimie. 2004. PMID: 15194235
A continuous enzyme assay and characterisation of fructosyl amine oxidase enzymes (EC 1.5.3).
Miller AG, Hegge S, Uhlmann A, Gerrard JA. Miller AG, et al. Among authors: gerrard ja. Arch Biochem Biophys. 2005 Feb 1;434(1):60-6. doi: 10.1016/j.abb.2004.10.021. Arch Biochem Biophys. 2005. PMID: 15629109
Two new irreversible inhibitors of dihydrodipicolinate synthase: diethyl (E,E)-4-oxo-2,5-heptadienedioate and diethyl (E)-4-oxo-2-heptenedioate.
Turner JJ, Healy JP, Dobson RC, Gerrard JA, Hutton CA. Turner JJ, et al. Among authors: gerrard ja. Bioorg Med Chem Lett. 2005 Feb 15;15(4):995-8. doi: 10.1016/j.bmcl.2004.12.043. Bioorg Med Chem Lett. 2005. PMID: 15686899
Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive.
Turner JJ, Gerrard JA, Hutton CA. Turner JJ, et al. Among authors: gerrard ja. Bioorg Med Chem. 2005 Mar 15;13(6):2133-40. doi: 10.1016/j.bmc.2005.01.001. Bioorg Med Chem. 2005. PMID: 15727866
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