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IL-2 responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2Rbeta transgenic mice.
Gesbert F, Moreau JL, Thèze J. Gesbert F, et al. Int Immunol. 2005 Aug;17(8):1093-102. doi: 10.1093/intimm/dxh289. Epub 2005 Jul 21. Int Immunol. 2005. PMID: 16037071
Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment.
Montes de Oca P, Malardé V, Proust R, Dautry-Varsat A, Gesbert F. Montes de Oca P, et al. Among authors: gesbert f. J Biol Chem. 2010 Jul 16;285(29):22050-8. doi: 10.1074/jbc.M109.093088. Epub 2010 May 21. J Biol Chem. 2010. PMID: 20495002 Free PMC article.
Interaction of the tyrosine phosphatase SHP-2 with Gab2 regulates Rho-dependent activation of the c-fos serum response element by interleukin-2.
Arnaud M, Mzali R, Gesbert F, Crouin C, Guenzi C, Vermot-Desroches C, Wijdenes J, Courtois G, Bernard O, Bertoglio J. Arnaud M, et al. Among authors: gesbert f. Biochem J. 2004 Sep 1;382(Pt 2):545-56. doi: 10.1042/BJ20040103. Biochem J. 2004. PMID: 15170389 Free PMC article.
Ubiquitination of the common cytokine receptor gammac and regulation of expression by an ubiquitination/deubiquitination machinery.
Gesbert F, Malardé V, Dautry-Varsat A. Gesbert F, et al. Biochem Biophys Res Commun. 2005 Aug 26;334(2):474-80. doi: 10.1016/j.bbrc.2005.06.121. Biochem Biophys Res Commun. 2005. PMID: 16004964
IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork.
Pillet AH, Lavergne V, Pasquier V, Gesbert F, Thèze J, Rose T. Pillet AH, et al. Among authors: gesbert f. J Mol Biol. 2010 Nov 12;403(5):671-92. doi: 10.1016/j.jmb.2010.08.056. Epub 2010 Sep 21. J Mol Biol. 2010. PMID: 20816854
Human IL-Rbeta chains form IL-2 binding homodimers.
Pillet AH, Juffroy O, Mazard-Pasquier V, Moreau JL, Gesbert F, Chastagner P, Colle JH, Thèze J, Rose T. Pillet AH, et al. Among authors: gesbert f. Eur Cytokine Netw. 2008 Mar;19(1):49-59. doi: 10.1684/ecn.2008.0120. Epub 2008 Feb 26. Eur Cytokine Netw. 2008. PMID: 18299274
NEDD4-2 associates with gamma(c) and regulates its degradation rate.
Malardé V, Proust R, Dautry-Varsat A, Gesbert F. Malardé V, et al. Among authors: gesbert f. Biochem Biophys Res Commun. 2009 Sep 18;387(2):409-13. doi: 10.1016/j.bbrc.2009.07.041. Epub 2009 Jul 15. Biochem Biophys Res Commun. 2009. PMID: 19615332
Recent advances in the understanding of interleukin-2 signal transduction.
Gesbert F, Delespine-Carmagnat M, Bertoglio J. Gesbert F, et al. J Clin Immunol. 1998 Sep;18(5):307-20. doi: 10.1023/a:1023223614407. J Clin Immunol. 1998. PMID: 9793823 Review.
A new tyrosine-phosphorylated 97-kDa adaptor protein mediates interleukin-2-induced association of SHP-2 with p85-phosphatidylinositol 3-kinase in human T lymphocytes.
Gesbert F, Guenzi C, Bertoglio J. Gesbert F, et al. J Biol Chem. 1998 Jul 17;273(29):18273-81. doi: 10.1074/jbc.273.29.18273. J Biol Chem. 1998. PMID: 9660791
Interleukin-2 stimulation induces tyrosine phosphorylation of p120-Cbl and CrkL and formation of multimolecular signaling complexes in T lymphocytes and natural killer cells.
Gesbert F, Garbay C, Bertoglio J. Gesbert F, et al. J Biol Chem. 1998 Feb 13;273(7):3986-93. doi: 10.1074/jbc.273.7.3986. J Biol Chem. 1998. PMID: 9461587
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