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Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status.
Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD. Everard A, et al. Among authors: geurts l. Nat Commun. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648. Nat Commun. 2014. PMID: 25476696 Free PMC article.
Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis.
Everard A, Plovier H, Rastelli M, Van Hul M, de Wouters d'Oplinter A, Geurts L, Druart C, Robine S, Delzenne NM, Muccioli GG, de Vos WM, Luquet S, Flamand N, Di Marzo V, Cani PD. Everard A, et al. Among authors: geurts l. Nat Commun. 2019 Jan 28;10(1):457. doi: 10.1038/s41467-018-08051-7. Nat Commun. 2019. PMID: 30692526 Free PMC article.
Reduced obesity, diabetes, and steatosis upon cinnamon and grape pomace are associated with changes in gut microbiota and markers of gut barrier.
Van Hul M, Geurts L, Plovier H, Druart C, Everard A, Ståhlman M, Rhimi M, Chira K, Teissedre PL, Delzenne NM, Maguin E, Guilbot A, Brochot A, Gérard P, Bäckhed F, Cani PD. Van Hul M, et al. Among authors: geurts l. Am J Physiol Endocrinol Metab. 2018 Apr 1;314(4):E334-E352. doi: 10.1152/ajpendo.00107.2017. Epub 2017 Sep 5. Am J Physiol Endocrinol Metab. 2018. PMID: 28874357
A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice.
Plovier H, Everard A, Druart C, Depommier C, Van Hul M, Geurts L, Chilloux J, Ottman N, Duparc T, Lichtenstein L, Myridakis A, Delzenne NM, Klievink J, Bhattacharjee A, van der Ark KC, Aalvink S, Martinez LO, Dumas ME, Maiter D, Loumaye A, Hermans MP, Thissen JP, Belzer C, de Vos WM, Cani PD. Plovier H, et al. Among authors: geurts l. Nat Med. 2017 Jan;23(1):107-113. doi: 10.1038/nm.4236. Epub 2016 Nov 28. Nat Med. 2017. PMID: 27892954 Clinical Trial.
Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism.
Duparc T, Plovier H, Marrachelli VG, Van Hul M, Essaghir A, Ståhlman M, Matamoros S, Geurts L, Pardo-Tendero MM, Druart C, Delzenne NM, Demoulin JB, van der Merwe SW, van Pelt J, Bäckhed F, Monleon D, Everard A, Cani PD. Duparc T, et al. Among authors: geurts l. Gut. 2017 Apr;66(4):620-632. doi: 10.1136/gutjnl-2015-310904. Epub 2016 May 5. Gut. 2017. PMID: 27196572 Free PMC article.
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