Gewirth DT - Search Results

1

Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.

Huck JD, Que NLS, Sharma S, Taldone T, Chiosis G, Gewirth DT. Huck JD, et al. Among authors: gewirth dt. Proteins. 2019 Oct;87(10):869-877. doi: 10.1002/prot.25750. Epub 2019 Jun 12. Proteins. 2019. PMID: 31141217 Free PMC article.

2

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Patel HJ, Patel PD, Ochiana SO, Yan P, Sun W, Patel MR, Shah SK, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, Gewirth DT, Taldone T, Chiosis G. Patel HJ, et al. Among authors: gewirth dt. J Med Chem. 2015 May 14;58(9):3922-43. doi: 10.1021/acs.jmedchem.5b00197. Epub 2015 Apr 22. J Med Chem. 2015. PMID: 25901531 Free PMC article.

3

Exploring the Functional Complementation between Grp94 and Hsp90.

Maharaj KA, Que NL, Hong F, Huck JD, Gill SK, Wu S, Li Z, Gewirth DT. Maharaj KA, et al. Among authors: gewirth dt. PLoS One. 2016 Nov 8;11(11):e0166271. doi: 10.1371/journal.pone.0166271. eCollection 2016. PLoS One. 2016. PMID: 27824935 Free PMC article.

4

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.

Huck JD, Que NL, Hong F, Li Z, Gewirth DT. Huck JD, et al. Among authors: gewirth dt. Cell Rep. 2017 Sep 19;20(12):2800-2809. doi: 10.1016/j.celrep.2017.08.079. Cell Rep. 2017. PMID: 28930677 Free PMC article.

5

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.

Que NLS, Crowley VM, Duerfeldt AS, Zhao J, Kent CN, Blagg BSJ, Gewirth DT. Que NLS, et al. Among authors: gewirth dt. J Med Chem. 2018 Apr 12;61(7):2793-2805. doi: 10.1021/acs.jmedchem.7b01608. Epub 2018 Mar 20. J Med Chem. 2018. PMID: 29528635 Free PMC article.

6

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.

Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D, Chiosis G. Taldone T, et al. J Med Chem. 2013 Sep 12;56(17):6803-18. doi: 10.1021/jm400619b. Epub 2013 Aug 21. J Med Chem. 2013. PMID: 23965125 Free PMC article.

7

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G. He H, et al. Among authors: gewirth dt. J Med Chem. 2006 Jan 12;49(1):381-90. doi: 10.1021/jm0508078. J Med Chem. 2006. PMID: 16392823

8

Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.

Immormino RM, Kang Y, Chiosis G, Gewirth DT. Immormino RM, et al. Among authors: gewirth dt. J Med Chem. 2006 Aug 10;49(16):4953-60. doi: 10.1021/jm060297x. J Med Chem. 2006. PMID: 16884307

9

Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.

Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Patel PD, et al. Among authors: gewirth dt. Nat Chem Biol. 2013 Nov;9(11):677-84. doi: 10.1038/nchembio.1335. Epub 2013 Sep 1. Nat Chem Biol. 2013. PMID: 23995768 Free PMC article.

10

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.

Huck JD, Que NLS, Immormino RM, Shrestha L, Taldone T, Chiosis G, Gewirth DT. Huck JD, et al. Among authors: gewirth dt. J Biol Chem. 2019 Nov 1;294(44):16010-16019. doi: 10.1074/jbc.RA119.009960. Epub 2019 Sep 9. J Biol Chem. 2019. PMID: 31501246 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

46 results

Search Page